// Li Cao 1 , Chaowu Chen 2 , Haihang Zhu 2 , Xuewen Gu 1 , Denghao Deng 2 , Xiuchun Tian 1 , Jun Liu 2 , Qin Xiao 1 1 Department of Pathology, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, P.R. China 2 Department of Gastroenterology, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, P.R. China Correspondence to: Chaowu Chen, email: doctorchencw@163.com Keywords: gastric cancer, MMP16, survival analysis, proliferation, invasion Received: March 30, 2016 Accepted: June 06, 2016 Published: June 20, 2016 ABSTRACT Matrix metalloproteinases (MMPs) are closely associated with tumor proliferation, invasion and metastasis. In this study, we determined the MMPs expression and their clinical significances in gastric cancer (GC). We first extensive studied MMPs expression in GC in The Cancer Genome Atlas (TCGA) RNA sequence database and found MMP16 was candidate biomarker in GC. Then we validated clinical significance of MMP16 mRNA expression in 167 GC by RT-PCR. Survival analysis showed that high expression of MMP16 indicated poor overall and disease free survival (P<0.001). The proliferation and invasion potential of GC cells were determined by CCK8, colony formation and Transwell assays. Silencing of MMP16 expression significantly decreased the invasion and proliferation capacity of GC cells (P<0.05). In conclusion, MMP16 was highly expressed and correlated with poor prognosis in GC patients by promoting proliferation and invasion of GC cells. MMP16 could be a novel molecular target and prognostic marker for GC.
In this paper, we study the impact of city driveway occupancy on the urban road traffic capacity. Through the analysis of the scene of an accident case, we gained the vehicle statistics within a cross section in unit time and then did calculation and simulation. The work is concluded as a reasonable model of vehicle queue relationship evaluation.First, on the base of the definition of traffic capacity, statistics of the cars in the cross section before the accident, during the accident and after the accident have been respectively acquired in unit time (1 min). Then we employ Matlab to do the interpolation fitting, drawing the change of actual capacity of the road from the beginning time of an accident to the time when traffic resumes. The work comes to a conclusion that the change of the capacity at the cross section has a pattern of periodic fluctuation.
CeNbTi catalyst was poisoned in different sulfur poisoning atmospheres at 300 °C for 6 h and then was evaluated for selective catalytic reduction (SCR) of NOx with NH3. The catalyst deactivation upon SO2 exposure was effectively inhibited in the presence of NH3. Temperature-programmed decomposition (TPD) analyses were applied to identify deposit species on the poisoned catalysts by comparison with several groups of reference samples. Diffuses reflectance infrared Fourier transform spectroscopy (DRIFTS) over CeNbTi catalysts with different poisoning pretreatments and gas purging sequences were designed to investigate the roles of NH3 in the removal of surface sulfites and sulfates. More ammonium sulfates including ammonium bisulfate and ammonium cerium sulfate were generated instead of inert cerium sulfate in these conditions. The mechanisms about the formation and transformation of surface deposits upon sulfur poisoning w/wo NH3 were explored, which provided a basis for developing Ce-based mixed oxides as SCR catalysts for stationary sources.
Proximity-enabled SuFEx reaction between interacting proteins was found to follow a two-step mechanism. Kinetics and essential properties were thoroughly studied for SuFEx applications in protein cross-linking and covalent biotherapeutics.
A novel multiwalled carbon nanotube/polypropylene (CNT/PP) conductive fibrous membrane with fiber diameter of 1–3 μm was fabricated by melt electrospinning. To improve the dispersibility of CNT and enhance the spinnability of PP fibers, CNTs were first mixed with small amounts of paraffin liquid (PL) and then melt-blended with PP for melt electrospinning. The morphology of fibrous membranes and the orientation of CNTs in PP fibers were observed via scanning and transmission electron microscopy (SEM and TEM). The effect of PL and CNTs on crystallization behavior of PP was studied by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). Tensile test and impedance analysis were performed to investigate the mechanical and electrical properties of the fibrous membranes. The results indicated that CNT has a distinct nucleating effect on PP, and the addition of PL can improve the spinnability of the CNT/PP compound remarkably. This novel conductive fibrous membrane fabricated by melt electrospinning exhibits improved tensile strength and modulus, good electric conductivity, and enhanced dielectric constant and hydrophobicity.
Porous TiC-TiB 2 -NiAl composites have been prepared through self-propagating high-temperature synthesis (SHS) of 3Ti + B 4 C + x(Ni+Al) → TiC + 2TiB 2 + xNiAl using Ni, Al, Ti, B 4 C powders as raw materials. The effects of Ni and Al content on phase constitution and pore structure of the obtained porous TiC-TiB 2 -NiAl composites have been investigated. XRD results show that the final composites of Ti+B 4 C+Ni+Al powders consist of TiC, TiB 2 and NiAl, while only TiC and TiB 2 are observed without using Ni+Al powders in the reaction system. NiAl additives play a significant role in controlling reaction behavior and constituents of the final products. TiC, TiB 2 and NiAl are homogenously distributed in porous TiC-TiB 2 -NiAl composites, and TiC shows spherical shape, TiB 2 exhibits hexagon or long strip shape while NiAl shows the irregular shape distributed between TiB 2 and TiC particles. The prepared TiC-TiB 2 -NiAl composites contain a large amount of pores with the aperture concentrating between 20-80μm and the porosity was about 35%, NiAl additives make the pores distributed uniformly in the matrix. The more NiAl additives, the more obvious of melting trace on the matrix skeleton, some spherical particles adhering on pore wall gradually submerge in matrix and combine with it closely. The NiAl additives increase the compressive strength of TiC-TiB 2 and for TiC-TiB 2 -NiAl composites, the fracture mode of TiB 2 and TiC is brittle fracture, while NiAl mainly occur transgranular fracture.
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