Rosa A. Bobadilla-Lugo

Instituto Politécnico Nacional

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Pedro López‐Sánchez

Instituto Politécnico Nacional

Víctor Pérez-Álvarez

University of Manitoba

Cecilia Tufiño

Instituto Politécnico Nacional

Enrique F. Castillo

Instituto Politécnico Nacional

Daniel Godínez‐Hernández

Universidad Michoacana de San Nicolás de Hidalgo

Cleva Villanueva

Instituto Politécnico Nacional

Ismael Bracho Valdés

Instituto Politécnico Nacional

Ismael Bracho-Valdés

Universidad de Guadalajara

Enrique Hong

Instituto Politécnico Nacional

Carlos Seré Rabé

Cooperative Institutions

Instituto Politécnico Nacional

Center for Research and Advanced Studies of the National Polytechnic Institute

Tecnológico Nacional de México

Centro Medico Nacional Siglo XXI

Mexican Social Security Institute

Universidad Nacional Autónoma de México

Centro Médico Nacional La Raza

Hospital de Especialidades

Centro de Investigación en Materiales Avanzados

Post Graduate Institute of Medical Education and Research

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Placental Effects of Systemic Tumour Necrosis Factor-α in an Animal Model of Gestational Diabetes Mellitus

Placenta (2010)

Rosa A. Bobadilla-Lugo Rita van Bree L. Vercruysse Robert Pijnenborg Johan Verhaeghe

10.1016/j.placenta.2010.09.017

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Citations (12)

Structure–hepatoprotective activity relationship of 3,4‐dihydroxycinnamic acid (caffeic acid) derivatives

Journal of Applied Toxicology (2001)

Víctor Pérez-Álvarez Rosa A. Bobadilla-Lugo Pablo Muriel

Abstract 3,4‐Dihydroxycinnamic acid (caffeic acid, CAF) is a natural product containing a catechol group with an α,β‐unsaturated carboxylic acid chain that has shown hepatoprotective properties. The aim of this work was to determine the importance of the 4‐hydroxy, 3‐hydroxy, 3,4‐dihydroxy substituents and the double bond moiety on the hepatic pharmacological effects of the molecule. We compared the ability of the caffeic, 4‐hydroxycinnamic, 3‐hydroxycinnamic, cinnamic and 3,4‐dihydroxyhydrocinnamic (a caffeic acid analogue without the double bond) acids at a dose of 50 mg kg −1 , p.o., to reduce the liver damage produced by CCl 4 (4 g kg −1 , p.o.) intoxication in the rat. Cinnamic acid, the non‐hydroxylated analogue, only modestly protected the experimental animals challenged with CCl 4 , suggesting that hydroxyl groups participate in the pharmacological properties of CAF. The 3,4‐dihydroxyhydrocinnamic derivative did not show any significant differences when compared with the CAF effect in this model, suggesting that the double bond does not account for the liver pharmacological properties of CAF. In contrast, the 4‐hydroxy substituent seems to be very important for hepatoprotective activity because the 4‐hydroxy analogue improved almost every hepatic injury marker altered by CCl 4 , and in a better way than CAF did. Copyright © 2001 John Wiley & Sons, Ltd.

Cinnamic acid

Moiety

Cinnamates

10.1002/jat.806

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Citations (61)

Subrenal aortic coarctation: Characterization as a pregnancy-induced hypertension model in the rat

Proceedings of the Western Pharmacology Society (2006)

Pedro López‐Sánchez Pedro Alejandro Reyes Melchor Liliana Anguiano Robledo Rosa A. Bobadilla-Lugo

Deficient uteroplacental perfusion is a well recognized feature in all preeclampsia syndromes. In the present work, we propose a simple method of reducing uterine blood flow and producing feto-placental ischemia by a partial constriction of the aorta below the renal arteries in the rat. The procedure gives rise to significant pregnancy induced hypertension, proteinuria, edema and intrauterine growth restriction, a syndrome that closely resembles preeclampsia in women. Therefore we conclude that this experimental model constitutes a tool that widens the possibilities for the study of this disease and suggest that the method be employed by others to further validate its

Constriction

Intrauterine growth restriction

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Epicatechin effect in an experimental pre-eclampsia model

Physiology (2023)

Cecilia Tufiño Luis Soto Betzabel Rodríguez Damián Madrigal Rosa A. Bobadilla-Lugo

Epicatechin effect in an experimental pre-eclampsia model Cecilia del Carmen Tufiño Martínez, Luis Jonathan Soto Ramírez, Betzabel Reyes Rodríguez, Damián Arturo Madrigal Aguilar, Rosa Amalia Bobadilla Lugo.Escuela Superior de Medicina del Instituto Politécnico Nacional (Salvador Díaz Mirón esq. Plan de San Luis S/N, Miguel Hidalgo, Casco de Santo Tomas, 11340 Ciudad de México, CDMX)Preclampsia (PE) is a pregnancy specific disorder characterized by de novo development of hypertension and proteinuria. Both the pathophysiology and the treatment of this disease are not clearly established. Epicatechin is a natural product that has shown beneficial effects in several conditions including hypertensive as well as having recognized antioxidant capacity. The objective of this work was to evaluate if the Epicatechin can reduce blood pressure and vascular contractility in an experimental model of preclampsia. For this purpose, 250g ± 50 pregnant female Wistar rats at term were divided into control and with subrenal aortic coarctation or PE, and treated: a) Vehicle, b) epicatechin (10 mg/Kg/day) p.o. during the first two weeks or c) epicatechin (10 mg/Kg/day) p.o. during the last two weeks of gestation. Blood pressure and weight were recorded, and a glucose tolerance curve was performed. The animals were sacrificed at term (day 20) to assess vascular contractility in aortic rings using a conventional isolated organ device. The results showed that rats with PE have an increase in systolic blood pressure, blood glucose and vascular contractility (abdominal aorta) compared to rats with normal pregnancy. Epicatechin administration during the 1st and 2nd week decrease systolic blood pressure, and the contractile response to phenylephrine and angiotensin II in the abdominal segment but not in the thoracic segment of the aorta of preclamptic rats. We conclude that preventive epicatechin treatment improves systolic blood pressure increase observed in the preclampsia model. However, results suggest epicatechin effect is more relevant on resistance than conductance vessels. Funding: Consejo Nacional de Ciencia y Tecnología (CONACyT) This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Contractility

Abdominal aorta

10.1152/physiol.2023.38.s1.5735192

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Reactivity changes in coronary artery and thoracic aorta in the gene mutant mice sgcd (B6.129 Sgcdtm1Mcn)

The FASEB Journal (2012)

Maria Carmen Marin-Romero Gustavo Guevara‐Balcázar Haydeé Rosas Ramón Mauricio Coral‐Vázquez Rosa A. Bobadilla-Lugo

Objective Study of cardiovascular reactivity changes in the gene mutant mice sgcd. Introduction Deletion of d‐sarcoglicano gene (delta‐SG) is related with structural and functional changes of squeletical, smooth and cardiac muscle which are related with limb‐girdle muscular dystrophy and cardiomiopathy. In this work we study the effect of some contractile and vasodilator agonist like angiotensin II and acethylcholine in this experimental model of dystrophy. Methods We used wild‐type and Knock‐out 5 months old female mice. We obtain thoracic aorta and the heart and both were immediately excised and placed in cold buffer, cleaned and freed from surrounding connective tissue. Isolated aortic rings and Langendorff system were maintained at 37° C, pH 7.4, were and bubbled with a mixture of 95% O 2 and 5% CO 2 . After that we probe angiotnesin II (10 −9 a 10 −6 M) with and without L‐NAME( sNOS antagonist) and indomethacin (COX‐1 and COX‐2 antagonist ). Results and conclusions We obtein significant differences between wild type and knock‐out mice, in the knock‐out mice we found an increase in the response of angiotensin II for that reason we suggest the participation of one contractile prostanoid in this effect. For that reason we decide to inhibit the contractile effect of angiotensin II with indometacin and the result was the inhibition of the contractile response. In other hand we analyse the vasodilator effect of acethylcholine at different concentrations and the result was less vasodilator effect in knock‐out mice, however we did not have differences in the vasodilator effect of nitroprusiate between wild type and knock‐out.

Wild type

Thoracic aorta

Knockout mouse

10.1096/fasebj.26.1_supplement.1115.7

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Effects of Selective 5-HT2 Receptor Antagonists on some Haemodynamic Changes Produced by Experimental Pulmonary Embolism in Rabbits

Birkhäuser Basel eBooks (1991)

J.L. Amezcua Enrique Hong Rosa A. Bobadilla-Lugo

Heparin, aspirin and the selective 5-HT2 antagonists ketanserin and pelanserin partially prevented the platelet-fall, rise en right ventricular pressure and systemic hypotension induced by the intravenous administration of an autologous clot or a suspension of collagen fibrils in rabbits. Whereas platelet-depletion nearly fully prevented the haemodynamic effects of the experimental thromboembolism. Intravenous 5-HT resembled the effects of pulmonary embolism and was only partially antagonized by the 5-HT2 receptor antagonists. These results suggest an additive role for platelet-derived vasoactive factors and thrombin in these experimental models and point out a role for 5-HT receptors eliciting reflex responses in the lung during the embolization.

Ketanserin

10.1007/978-3-0348-7259-1_41

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Citations (1)

The actions of alpha-methylnorepinephrine on the rat aorta.

PubMed (1996)

Enrique F. Castillo Carlos Castillo Ignacio Leyva-Valencia Diana R. Hernandez María Carlina Castillo

Alpha (finance)

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Author Index Vol. 84, 2009

Pharmacology (2009)

Sun Young Park Sung Uk Park Uy Dong Sohn Hiroki Fujitaka Akiko Okada

10.1159/000265546

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Impact of Normal and Overweight Pregnancy in GLUT4 and Glucose-Dependent Vascular Contractility

Pharmacology (2023)

Esther Juárez Cortes Gustavo López y López Eduardo I Pérez Muñoz Betzabel Rodríguez Reyes Damián A. Madrigal-Aguilar

Introduction: Obesity during pregnancy can contribute to hypertensive complications through changes in glucose utilization. We investigated the impact of vascular glucose uptake, GLUT4 density, and endothelium on agonist-induced vasoconstriction in the aortas of overweight pregnant rats. Methods: Isolated aortic rings with or without endothelium from pregnant or nonpregnant rats fed a standard (SD) or hypercaloric diet (HD) were contracted with phenylephrine or serotonin (10−9 to 10−4<sc>M</sc>) using standard (11 m<sc>m</sc>) or without (0 m<sc>m</sc>) glucose Krebs solution. GLUT4 density in the aortas was measured using the en face method. Results: Aortas from overweight pregnant animals (PHD) showed increased Phe-induced vasoconstriction (p < 0.05 vs. pregnant standard diet [PSD]), which was endothelium-independent. The contraction decreased significantly in the absence of glucose. In contrast, vessels from pregnant SD rats maintained their contraction in glucose-free Krebs solution. 5-HT increases PHD aortic contraction only in the absence of glucose. The fetal aortas from PHD mothers showed blunted vasoconstriction. Overweight significantly reduced GLUT4 expression in maternal and fetal aortas (p < 0.05 vs. PSD). Conclusions: Aortic contractility is independent of glucose uptake during healthy pregnancy. In contrast, overweight pregnancy increases contractility. This increase depends directly on smooth muscle glucose uptake and inversely on GLUT-4 density. The increased contraction observed in the vasculature of overweight mothers was inverted in the fetal aortas.

Contractility

GLUT4

Phenylephrine

10.1159/000533344

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Renal vascular responses in an experimental model of preeclampsia.

PubMed (2005)

Rosa A. Bobadilla-Lugo Víctor M. Pérez‐Álvarez Liliana Anguiano Robledo Pedro López‐Sánchez

In pregnancy there is an attenuated response to vasoconstrictors and pressor agents, including Angiotensin II (Ang II). This effect is reverted in preeclampsia. We evaluated the renal pressor response induced by Ang II in an experimental model of preeclampsia based on the development of feto-placental ischemia produced by a subrenal aortic coarctation (SRAC). Dose-response curves for Ang II were obtained in an isolated perfused kidney preparation comparing groups of SRAC pregnant and non-pregnant rats in the presence and absence of losartan (AT1 antagonist) or PD123319 (AT2 antagonist). Kidneys from the experimental model of pre-eclampsia showed an enhanced response to AngII. In addition, losartan (10 nM) inhibited the vasopressor effect to Ang II in this model but not in the control group. PD 123319 (1 nM), increased the response in both groups, but the effect was more evident in the pre-eclamptic group. This suggests modifications in the relative participation of renal vascular receptors AT1/AT2 induced by an experimental model of pre-eclampsia, with an increased participation of AT1 and a decreased participation of AT2.

Renal ischemia

Hydralazine

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Citations (2)