Anna Baldisserotto

University of Ferrara

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Stefano Manfredini

University of Ferrara

Silvia Vertuani

University of Ferrara

Mauro Marastoni

University of Ferrara

Riccardo Gavioli

University of Ferrara

Roberto Tomatis

University of Ferrara

Elisa Durini

University of Ferrara

Ilaria Lampronti

University of Ferrara

Raissa Buzzi

University of Ferrara

Elisabetta Esposito

University of Ferrara

Maddalena Sguizzato

University of Ferrara

Cooperative Institutions

University of Ferrara

132

Sapienza University of Rome

University of Padua

University of Cagliari

University of Bologna

Istituti di Ricovero e Cura a Carattere Scientifico

University of Modena and Reggio Emilia

University of Milan

Center for Translational Neurophysiology of Speech and Communication

National Institute of Environmental Health Sciences

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

α,β-Unsaturated N-Acylpyrrole Peptidyl Derivatives: New Proteasome Inhibitors

Journal of Medicinal Chemistry (2010)

Anna Baldisserotto V. Ferretti Federica Destro Christian Franceschini Mauro Marastoni

Because of the encouraging results obtained using vinyl ester derivatives, we synthesized and tested a novel series of peptide-based proteasome inhibitors bearing a new pharmacophore unit at the C-terminal. N-Acylpyrrole moiety is a potential substrate for Michael addition by catalytic threonine. Several analogues have demonstrated a selective inhibition of the multicatalytic complex β1 subunits, the capacity to permeate cellular membrane, and good pharmacokinetics properties.

10.1021/jm100122e

Cite

Citations (17)

A Multitarget Approach toward the Development of 8-Substituted Purines for Photoprotection and Prevention of UV-Related Damage

ChemMedChem (2017)

Ernestine Nicaise Djuidje Valeria Dissette Alessia Bino Simonetta Benetti Jan Balzarini

Ultraviolet (UV) light is the most abundant and significant modifiable risk factor for skin cancer and many other skin diseases such as early photo-aging. Across the solar radiation spectrum, UV light is the main cause behind skin problems. In the search for novel photoprotective compounds, a new series of 8-substituted purines were synthesized from commercially available 6-hydroxy-4,5-diaminopyrimidine hemisulfate or 4,5-diaminopyrimidine. All title compounds were investigated for their UV filtering, antioxidant, antifungal, and antiproliferative activities. For the photoprotection assays we used a diffuse transmittance technique to determine the sun protection factor (SPF) in vitro, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power (FRAP) tests for evaluating the antioxidant activity of the more potent compounds. Among them, 8-(2,5-dihydroxyphenyl)-7H-purin-6-ol (compound 26) proved to be a good radical scavenger and is also endowed with broad-spectrum UVA filtering capabilities, suitable for further development as a protective molecule.

Photoprotection

UV filter

Scavenger

Ultraviolet

10.1002/cmdc.201700137

Cite

Citations (4)

“Plurethosome” as Vesicular System for Cutaneous Administration of Mangiferin: Formulative Study and 3D Skin Tissue Evaluation

Pharmaceutics (2021)

Maddalena Sguizzato Francesca Ferrara Paolo Mariani Alessia Pepe Rita Cortesi

Human skin is dramatically exposed to toxic pollutants such as ozone. To counteract the skin disorders induced by the air pollution, natural antioxidants such as mangiferin could be employed. A formulative study for the development of vesicular systems for mangiferin based on phosphatidylcholine and the block copolymer pluronic is described. Plurethosomes were designed for mangiferin transdermal administration and compared to ethosome and transethosome. Particularly, the effect of vesicle composition was investigated on size distribution, inner and outer morphology by photon correlation spectroscopy, small angle X-ray diffraction, and transmission electron microscopy. The potential of selected formulations as vehicles for mangiferin was studied, evaluating encapsulation efficiency and in vitro diffusion parameters by Franz cells. The mangiferin antioxidant capacity was verified by the 2,2-diphenyl-1-picrylhydrazyl assay. Vesicle size spanned between 200 and 550 nm, being influenced by phosphatidylcholine concentration and by the presence of polysorbate or pluronic. The vesicle supramolecular structure was multilamellar in the case of ethosome or plurethosome and unilamellar in the case of transethosome. A linear diffusion of mangiferin in the case of ethosome and transethosomes and a biphasic profile in the case of plurethosomes indicated the capability of multilamellar vesicles to retain the drug more efficaciously than the unilamellar ones. The antioxidant and anti-inflammatory potential effect of mangiferin against pollutants was evaluated on 3D human skin models exposed to O3. The protective effect exerted by plurethosomes and transethosomes suggests their possible application to enhance the cutaneous antioxidant defense status.

Mangiferin

10.3390/pharmaceutics13081124

Cite

Citations (16)

Lipid-Based Nanosystems for the Topical Application of Ferulic Acid: A Comparative Study

Pharmaceutics (2023)

Maddalena Sguizzato Francesca Ferrara Markus Drechsler Anna Baldisserotto Leda Montesi

In this study, we examined and compared two different lipid-based nanosystems (LBNs), namely Transferosomes (TFs) and Monoolein Aqueous Dispersions (MADs), as delivery systems for the topical application of Ferulic Acid (FA), an antioxidant molecule derived from natural sources. Our results, as demonstrated through Franz-cell experiments, indicate that the LBNs produced with poloxamer 188 in their composition create a multilamellar system. This system effectively controls the release of the drug. Nonetheless, we found that the type of non-ionic surfactant can impact the drug release rate. Regarding FA diffusion from the MAD, this showed a lower diffusion rate compared with the TF. In terms of an in vivo application, patch tests revealed that all LBN formulations tested were safe when applied under occlusive conditions for 48 h. Additionally, human skin biopsies were used to determine whether FA-containing formulations could influence skin tissue morphology or provide protection against O3 exposure. Analyses suggest that treatment with TFs composed of poloxamer 188 and MAD formulations might protect against structural skin damage (as observed in hematoxylin/eosin staining) and the development of an oxidative environment (as indicated by 4-hyroxinonenal (4HNE) expression levels) induced by O3 exposure. In contrast, formulations without the active ingredient did not offer protection against the detrimental effects of O3 exposure.Inizio modulo.

Poloxamer 407

10.3390/pharmaceutics15071940

Cite

Citations (3)

Essential oil extraction, chemical analysis and anti-Candida activity of Foeniculum vulgare Miller – new approaches

Natural Product Research (2017)

Stefania Garzoli Mijat Božović Anna Baldisserotto Manuela Sabatino Stefania Cesa

A comprehensive study on essential oil samples of Foeniculum vulgare Miller from Tarquinia (Italy) is reported. A 24-h systematic steam distillation was performed on different harvested samples applying different extraction times. The GC-MS analysis of the residue outcome showed o-cymene, α-phellandrene, α-pinene and estragole as the major constituents. The predominance and continued presence of o-cymene makes this fennel oil a rather unique chemotype. An evident correlation between the antifungal activity and phenological stage is demonstrated. The most active fractions were particularly rich in estragole, as well as a significant amount of fenchone that possibly exerts some additive effect in the expression of overall antifungal potency. Pre-fruiting material produced oil particularly rich in o-cymene. With reference to the duration of the extraction, the maximum amount of oil was released within the first 3 h, whereas the reproductive phase material needed at least 6 h for the extraction.

Estragole

Foeniculum

p-Cymene

Chemotype

Steam distillation

Apiaceae

10.1080/14786419.2017.1340291

Cite

Citations (40)

Phloridzin derivatives inhibiting proinflammatory cytokine expression in human cystic fibrosis IB3-1 cells

International Journal of Molecular Medicine (2015)

Ilaria Lampronti Roberta Milani Giulia Montagner Andrea Marcellini Anna Baldisserotto

Proinflammatory cytokine

Source

Cite

Citations (0)

Benzothiazole Derivatives as Multifunctional Antioxidant Agents for Skin Damage: Structure–Activity Relationship of a Scaffold Bearing a Five-Membered Ring System

Antioxidants (2022)

Ernestine Nicaise Djuidje Riccardo Barbari Anna Baldisserotto Elisa Durini Sabrina Sciabica

Skin diseases often give multifactorial damages; therefore, the development of multifunctional compounds represents a suitable approach especially against disorders that are induced by oxidative stress. Thus, taking into account the successful results we achieved on benzimidazoles, we have devised a new series of isosteric benzothiazoles and investigated their antioxidant, photoprotective, antifungal and antiproliferative activity. Particular attention has been paid to synergistic antioxidant and photoprotective properties. For compounds 9a and 10a, a multifunctional profile was outlined, supported by an excellent filtering capacity, mainly UVB, which has higher capacities than those of the reference PBSA which is currently in the market as a UV sunscreen filter. The two compounds were also the best in terms of growth inhibition of dermatophytes and Candida albicans, and 10a also showed good antioxidant activity. Furthermore, 9a was also effective on melanoma tumor cells (SK-Mel 5), making these compounds good candidates in the development of new skin protective and preventive agents.

Benzothiazole

10.3390/antiox11020407

Cite

Citations (24)

Application of the “in-oil nanoprecipitation” method in the encapsulation of hydrophilic drugs in PLGA nanoparticles

Journal of Drug Delivery Science and Technology (2015)

Alessandro Dalpiaz Francesca Sacchetti Anna Baldisserotto Barbara Pavan Eleonora Maretti

PLGA

Diclofenac Sodium

Excipient

Microparticle

10.1016/j.jddst.2015.07.020

Cite

Citations (32)

Machine Learning Data Augmentation as a Tool to Enhance Quantitative Composition–Activity Relationships of Complex Mixtures. A New Application to Dissect the Role of Main Chemical Components in Bioactive Essential Oils

Molecules (2021)

Alessio Ragno Anna Baldisserotto Lorenzo Antonini Manuela Sabatino Filippo Sapienza

Scientific investigation on essential oils composition and the related biological profile are continuously growing. Nevertheless, only a few studies have been performed on the relationships between chemical composition and biological data. Herein, the investigation of 61 assayed essential oils is reported focusing on their inhibition activity against

Python

Compositional data

Biological data

10.3390/molecules26206279

Cite

Citations (4)

Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity

European Journal of Medicinal Chemistry (2018)

Anna Baldisserotto Monica Demurtas Ilaria Lampronti Davide Moi Gianfranco Balboni

Benzofuran

Moiety

Derivative (finance)

10.1016/j.ejmech.2018.07.001

Cite

Citations (52)