Tibor Dubaj

Slovak University of Technology in Bratislava

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PŠ

Peter Šimon

Slovak University of Technology in Bratislava

Jozef Kožı́šek

Slovak University of Technology in Bratislava

Zuzana Cibulková

Slovak University of Technology in Bratislava

IŠ

Ivan Šalitroš

Central European Institute of Technology

Miroslav Veverka

Martin University Hospital

Barbora Brachňaková

Slovak University of Technology in Bratislava

Eva Melníková

Slovak University of Technology in Bratislava

Radovan Herchel

Palacký University Olomouc

Miroslav Gál

Slovak University of Technology in Bratislava

Júlia Kožíšková

Slovak University of Technology in Bratislava

Cooperative Institutions

Slovak University of Technology in Bratislava

Slovak Academy of Sciences

Comenius University Bratislava

Chinese Academy of Sciences

Polymer Institute of the Slovak Academy of Sciences

Biomedical Research Center of the Slovak Academy of Sciences

Institute of Food Science and Technology

Cancer Research Institute of the Slovak Academy of Sciences

Fraunhofer Institute for Biomedical Engineering

Fraunhofer Society

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Physicochemical and biological properties of luteolin-7-O-β-d-glucoside (cynaroside) isolated from Anthriscus sylvestris (L.) Hoffm.

Monatshefte für Chemie - Chemical Monthly (2014)

Lukáš Žemlička Peter Fodran Vladimı́r Lukeš Adam Vagánek Mariana Slováková

ABTS

10.1007/s00706-014-1228-3

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Citations (30)

A simple degradation model for materials in combined thermal and radiation environments

AIP conference proceedings (2019)

Anna Vykydalová Zuzana Cibulková Tibor Dubaj Peter Šimon

Polymers are sensitive to changes in chemical structure caused by external conditions. The changes caused by these factors, ageing or degradation, are undesirable. Thermooxidative degradation takes place in two steps. The first step is induction period (IP), where seemingly no chemical reaction takes place. The second step, oxidation itself, begins at the end of IP. At the end of IP, a rapid oxygen uptake associated with a sudden change of material characteristics occurs. Therefore, the length of the IP is frequently taken as a measure of a material stability. The aim of this study was to develop a predictive model for stability of coaxial cable insulations used in nuclear power plants. Studied was an unaged cable sample and cables aged by various degradation doses of heat, radiation and combination of these factors. Stability of cables was studied by non-isothermal DSC measurements and isoconversional kinetic analysis was carried out using non-Arrhenian temperature function. From the values of kinetic parameters IPs and residual stabilities were calculated and a model for the cable service life was developed based on the thermal and radiation stress tests. The model assumes first-order exponential decay of residual stability with the degradation dose and allows one to predict the degree of insulation damage in a wide range of environmental conditions.

Degradation

Isothermal process

Service life

Thermal Stability

10.1063/1.5120171

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A new phenomenon of various polarity observed in p-menthane-1,2,4-triol

Monatshefte für Chemie - Chemical Monthly (2015)

Peter Fodran Andrea Marko Lukáš Žemlička Jozef Kožı́šek Tibor Liptaj

Triol

Polarity (international relations)

10.1007/s00706-015-1455-2

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Citations (1)

Equivalence of the Arrhenius and Non-Arrhenian Temperature Functions in the Temperature Range of Measurement and Its Application in Isoconversional Kinetics

Hot topics in thermal analysis and calorimetry (2017)

Peter Šimon Tibor Dubaj Zuzana Cibulková

Atmospheric temperature range

10.1007/978-3-319-45899-1_13

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CCDC 1935030: Experimental Crystal Structure Determination

The Cambridge Structural Database (2020)

Barbora Brachňaková Júlia Kožíšková Jozef Kožı́šek Eva Melníková Miroslav Gál

10.5517/ccdc.csd.cc22ykby

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Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening

Small (2021)

Yvonne Kohl Margit Biehl Sarah Spring Michelle Hesler Vladimir Ogourtsov

Abstract Microfluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses for rapid and animal‐free risk assessment of new chemicals and drugs. Microfluidic cell‐based devices allow high‐throughput screening and flexible automation while lowering costs and reagent consumption due to their miniaturization. There is a growing need for faster and animal‐free approaches for drug development and safety assessment of chemicals (Registration, Evaluation, Authorisation and Restriction of Chemical Substances, REACH). The work presented describes a microfluidic platform for in vivo‐like in vitro cell cultivation. It is equipped with a wafer‐based silicon chip including integrated electrodes and a microcavity. A proof‐of‐concept using different relevant cell models shows its suitability for label‐free assessment of cytotoxic effects. A miniaturized microscope within each module monitors cell morphology and proliferation. Electrodes integrated in the microfluidic channels allow the noninvasive monitoring of barrier integrity followed by a label‐free assessment of cytotoxic effects. Each microfluidic cell cultivation module can be operated individually or be interconnected in a flexible way. The interconnection of the different modules aims at simulation of the whole‐body exposure and response and can contribute to the replacement of animal testing in risk assessment studies in compliance with the 3Rs to replace, reduce, and refine animal experiments.

Organ-on-a-Chip

10.1002/smll.202006012

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Citations (36)

Beta-glucan and arabinogalactan-based xerogels for abuse-deterrent opioid formulations

European Journal of Pharmaceutical Sciences (2019)

Miroslav Veverka Tibor Dubaj Eva Veverková Peter Šimon Š. Husár

Mucilage

10.1016/j.ejps.2019.01.003

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Citations (9)

CCDC 2017391: Experimental Crystal Structure Determination

The Cambridge Structural Database (2020)

Barbora Brachňaková Júlia Kožíšková Jozef Kožı́šek Eva Melníková Miroslav Gál

10.5517/ccdc.csd.cc25q84b

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Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro—In Vivo Correlation

Nanomaterials (2022)

Tibor Dubaj Katarína Kozics Monika Šrámková Alena Manová Neus G. Bastús

Data suitable for assembling a physiologically-based pharmacokinetic (PBPK) model for nanoparticles (NPs) remain relatively scarce. Therefore, there is a trend in extrapolating the results of in vitro and in silico studies to in vivo nanoparticle hazard and risk assessment. To evaluate the reliability of such approach, a pharmacokinetic study was performed using the same polyethylene glycol-coated gold nanoparticles (PEG-AuNPs) in vitro and in vivo. As in vitro models, human cell lines TH1, A549, Hep G2, and 16HBE were employed. The in vivo PEG-AuNP biodistribution was assessed in rats. The internalization and exclusion of PEG-AuNPs in vitro were modeled as first-order rate processes with the partition coefficient describing the equilibrium distribution. The pharmacokinetic parameters were obtained by fitting the model to the in vitro data and subsequently used for PBPK simulation in vivo. Notable differences were observed in the internalized amount of Au in individual cell lines compared to the corresponding tissues in vivo, with the highest found for renal TH1 cells and kidneys. The main reason for these discrepancies is the absence of natural barriers in the in vitro conditions. Therefore, caution should be exercised when extrapolating in vitro data to predict the in vivo NP burden and response to exposure.

Biodistribution

10.3390/nano12030511

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Citations (27)

CCDC 2160315: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Lucia Feriancová Marek Cigáň Jozef Kožı́šek Katarína Gmucová Vojtěch Nádaždy

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2bhzlf

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