Aquaculture has gained prominence globally in recent years particularly in fish and shrimp production. The increased surge of demand has led to a rapid increase in several aquaculture setup implementations. However, it also has raised the risks of disease outbreaks leading to mass mortality rates caused by bacteria, viruses, and fungi. Also, inappropriate use of antibiotics leading to resistance in microbial pathogens is an expanding threat. Hence, feed preparation and characterization using ethnomedicinal plants could offer relief for the present requisite in aquaculture. Feed formulation by analyzing nutritional needs supplemented with ethnomedicinal plant-based feeds would benefit aquaculture in encountering antibiotic resistance. The feed formulation using plant-based feeds would envision natural solutions for infections along with economical sustainability with low-cost feed for the growing aquaculture industry.