Jiongming Li

Kunming Medical University

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Pei Li

Shandong First Medical University

Ziye Huang

Kunming Medical University

Jianhe Liu

Kunming Medical University

Tongxin Yang

Dalian University of Technology

Bowei Yang

University of Chicago

Guang Wang

Jinan University

Guang Wang

Beijing Chao-Yang Hospital

Yuyun Wu

Kunming Medical University

Fangjian Zhou

Sun Yat-sen University Cancer Center

Yongming Jiang

Affiliated Hospital of Youjiang Medical University for Nationalities

Cooperative Institutions

Kunming Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhejiang University

Sun Yat-sen University

Huazhong University of Science and Technology

Capital Medical University

Peking University

Fudan University

Fujian Medical University

Shanghai Jiao Tong University

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Osteopontin: An important protein in the formation of kidney stones

Frontiers in Pharmacology (2022)

Qingxia Jia Ziye Huang Guang Wang Xia Sun Yuyun Wu

The incidence of kidney stones averages 10%, and the recurrence rate of kidney stones is approximately 10% at 1 year, 35% at 5 years, 50% at 10 years, and 75% at 20 years. However, there is currently a lack of good medicines for the prevention and treatment of kidney stones. Osteopontin (OPN) is an important protein in kidney stone formation, but its role is controversial, with some studies suggesting that it inhibits stone formation, while other studies suggest that it can promote stone formation. OPN is a highly phosphorylated protein, and with the deepening of research, there is growing evidence that it promotes stone formation, and the phosphorylated protein is believed to have adhesion effect, promote stone aggregation and nucleation. In addition, OPN is closely related to immune cell infiltration, such as OPN as a pro-inflammatory factor, which can activate mast cells (degranulate to release various inflammatory factors), macrophages (differentiated into M1 macrophages), and T cells (differentiated into T1 cells) etc., and these inflammatory cells play a role in kidney damage and stone formation. In short, OPN mainly exists in the phosphorylated form in kidney stones, plays an important role in the formation of stones, and may be an important target for drug therapy of kidney stones.

Osteopontin

10.3389/fphar.2022.1036423

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Citations (18)

Bruton tyrosine kinase (BTK) may be a potential therapeutic target for interstitial cystitis/bladder pain syndrome

Aging (2022)

Guang Wang Tongxin Yang Jiongming Li Ziye Huang Wenbo Yang

Aims: To determine the potential diagnostic and therapeutic targets of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). Methods: We selected the GSE11783, GSE57560 and GSE621 datasets from the GEO database and merged them. R software was used to screen differentially expressed genes (DEGs) between IC/BPS and normal bladder tissues. The

Bladder Pain Syndrome

Therapeutic approach

10.18632/aging.204271

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Citations (3)

[Colorectal non-invasive epithelial lesions: conception of conventional adenoma and diagnosis of rare subtypes].

PubMed (2020)

Jiongming Li Xiaodong Teng Maode Lai

结直肠腺瘤是最常见的肠道病变，典型的腺瘤诊断相对简单，但少数腺瘤可以出现黏液/杯状细胞为主、潘氏细胞成分、神经内分泌细胞增生、鳞状体形成、透明细胞化生、嗜酸细胞化生或印戒细胞癌成分等病理改变，以及出现上皮错位或累及淋巴腺复合体等相对复杂情况，这些对腺瘤的诊断造成一定的困扰。作者梳理和归纳结直肠腺瘤相关的基本概念，并通过典型病例分析总结上述少见病变的诊断要点、鉴别诊断及临床病理意义。.

Colorectal adenoma

10.3760/cma.j.cn112151-20200316-00210

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N6-methyladenosine-related lncRNAs in combination with computational histopathology and radiomics predict the prognosis of bladder cancer

Translational Oncology (2022)

Ziye Huang Guang Wang Yuyun Wu Tongxin Yang Lishi Shao

Identification of m6A- related lncRNAs associated with BC diagnosis and prognosis.From the TCGA database, we obtained transcriptome data and corresponding clinical information (including histopathological and CT imaging data) for 408 patients. And bioinformatics, computational histopathology, and radiomics were used to identify and analyze diagnostic and prognostic biomarkers of m6A-related lncRNAs in BC.3 significantly high-expressed m6A-related lncRNAs were significantly associated with the prognosis of BC. The BC samples were divided into two subgroups based on the expression of the 3 lncRNAs. The overall survival of patients in cluster 2 was significantly lower than that in cluster 1. The immune landscape results showed that the expression of PD-L1, T cells follicular helper, NK cells resting, and mast cells activated in cluster 2 were significantly higher, and naive B cells, plasma cells, T cells regulatory (Tregs), and mast cells resting were significantly lower. Computational histopathology results showed a significantly higher percentage of tumor-infiltrating lymphocytes (TILs) in cluster 2. The radiomics results show that the 3 eigenvalues of diagnostics image-original minimum, diagnostics image-original maximum, and original GLCM inverse variance are significantly higher in cluster 2. High expression of 2 bridge genes in the PPI network of 30 key immune genes predicts poorer disease-free survival, while immunohistochemistry showed that their expression levels were significantly higher in high-grade BC than in low-grade BC and normal tissue.Based on the results of immune landscape, computational histopathology, and radiomics, these 3 m6A-related lncRNAs may be diagnostic and prognostic biomarkers for BC.

Histopathology

10.1016/j.tranon.2022.101581

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Citations (4)

Clinical practice guideline on bladder cancer (Part II)

UroPrecision (2023)

Xiying Dong Gang Song Kaopeng Guan Tie Wang Xiaoli Feng

Abstract Bladder cancer (BC) is an increasingly common malignancy in China, with an incidence rate of 5.80 per 100 000 in 2015, making it the thirteenth most common cancer in the country. This trend underscores the urgent need for standardized diagnosis and treatment protocols. In terms of treatment, approaches for bladder cancer vary based on the cancer's stage and pathology, as well as the patient's overall health. Notably, non‐muscle‐invasive BC (NMIBC) confined to the mucosa (Ta) and lamina propria (T1) without invading the muscle represents about 75% of all BC cases. Succeeding the first part of the guideline, this part of the clinical practice guideline focuses on NMIBC. It details risk classifications and treatment options, including both surgical procedures and posttransurethral resection of the bladder tumor intravesical instillations. Special attention is given to the treatment strategies for carcinoma in situ. The guideline also covers the recommended follow‐up procedures for patients with NMIBC, underscoring the need for thorough and continuous care management.

Guideline

Lamina propria

Carcinoma in situ

Clinical Practice

10.1002/uro2.35

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Citations (1)

Citrate primarily inhibits the formation of calcium oxalate kidney stones rather than dissolving them

Asian Journal of Surgery (2024)

Guang Wang Ziye Huang Hongfei Gao Jiongming Li

10.1016/j.asjsur.2024.04.011

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PARP inhibitors as maintenance therapy in newly diagnosed advanced ovarian cancer: a meta‐analysis

BJOG An International Journal of Obstetrics & Gynaecology (2020)

Qingqing Lin Wei Liu Sheng Xu H. Shang Jiongming Li

Up to 70% of patients with advanced ovarian cancer have a relapse after primary therapy. New agents and approaches are urgently needed to avoid or slow down this recurrence.To investigate the efficacy of PARP inhibitors (PARPis) as maintenance treatment in patients with newly diagnosed advanced ovarian cancer.PubMed, MEDLINE, EMBASE, Cochrane Library and Web of Science databases.All randomised clinical trials (RCTs) that compared PARPis with placebo as first-line maintenance therapy in ovarian cancer.Two reviewers extracted data. Pooled hazard ratio (HR) and risk ratio (RR) with 95% confidence interval (CI) were calculated.PARPis were associated with significant improvement of progression-free survival (PFS) in advanced epithelial ovarian cancer (AeOC) (HR = 0.53, 95% CI 0.40-0.71; P < 0.0001). The benefit was not only in women with BRCA mutations (HR = 0.35, 95% CI 0.29-0.42; P < 0.00001) and homologous recombination deficiency (HRD) (HR = 0.43, 95% CI 0.32-0.60; P < 0.00001), but also in those with nonmutated BRCA (HR = 0.72, 95% CI 0.63-0.82; P < 0.00001) and even non-HRD (HR = 0.83, 95% CI 0.70-0.99; P = 0.04).PARP inhibitors are effective as maintenance therapy among patients with newly diagnosed advanced ovarian cancer after platinum-based chemotherapy, regardless of BRCA mutation or HRD status.PARPis provide a significant PFS benefit as first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer.

BRCA Mutation

Maintenance therapy

10.1111/1471-0528.16411

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Citations (25)

The Animal Model of Kidney Calculus Induced by the Melamine and its Analogues

Kunming Yike Daxue xuebao (2010)

Jiongming Li

Cyanuric acid

Carboxymethyl cellulose

Blood urea nitrogen

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[Endoscopic transoral approach nasopharyngectomy for petroclival and jugular foramen nasopharyngeal carcinoma].

PubMed (2023)

H K Zhang Jiongming Li Xixi Jiang S Li Kang Xue

Objective: To describe a technique of endoscopic transoral approach nasopharyngectomy for petroclival and jugular foramen nasopharyngeal carcinoma, based on anatomic studies and surgeries. Methods: Three dry human skulls and five fresh human cadaver heads were used for anatomic study of a endoscopic transoral approach to expose petroclival and jugular foramen. The anatomical landmarks and the extent of exposure were recorded. Six clinical cases who were treated in Eye & ENT Hospital, Fudan University from June 2020 to April 2022 were used to illustrate the technique and feasibility of this approach and to assess its indications and advantages, including 3 males and 3 females, aged 42 to 69 years old. Descriptive analysis was used in this research. Results: On the basis of the preservation of the internal pterygoid muscle and the external pterygoid muscle, this approach could fully expose the parapharyngeal, petrosal and paraclival segment internal carotid arteries, and safely deal with the lesions of jugular foramen and petroclival region. The 6 patients in our study tolerated the procedure well. Postoperative enhanced MRI showed complete resection of the tumor and no postoperative masticatory dysfunction. Conclusion: Endoscopic transoral approach is a safe, minimally invasive and effective surgical treatment for petroclival and jugular foramen recurrent nasopharyngeal carcinoma.目的：探索内镜经口入路的解剖要点及其在岩斜区和颈静脉孔区复发性鼻咽癌（nasopharyngeal carcinoma，NPC）手术中的应用。方法：使用3个干性头颅骨性标本和5个新鲜冰冻尸头标本，采用经口入路显露岩斜区和颈静脉孔区，记录重要解剖标志及显露范围，详细介绍该入路的手术方法和技巧。回顾性分析于2020年6月至2022年4月就诊于复旦大学附属眼耳鼻喉科医院的复发性NPC患者6例，男女比例1∶1，年龄42~69岁，所有患者均使用该入路行岩斜区和颈静脉孔区复发性NPC切除术。采用描述性方法进行分析。结果：解剖研究显示，内镜经口入路在保留翼内肌和翼外肌的基础上，可显露咽旁段、岩骨段和斜坡旁段颈内动脉，可处理颈静脉孔区和岩斜区的病变。临床实践显示，6例患者均成功行内镜经口入路NPC切除术，术后增强MRI见肿瘤完整切除，患者无咀嚼功能障碍。结论：内镜经口入路用于岩斜区和颈静脉孔区复发性NPC切除术，具有安全、微创、可靠的特点，值得临床推广。.

Jugular foramen

Parapharyngeal space

10.3760/cma.j.cn115330-20220708-00426

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Citations (1)

Adrenocortical oncocytic carcinoma misdiagnosed as adrenal cortical adenoma

Asian Journal of Surgery (2024)

Yang Li Pei Li Fu-kai Tao Jiongming Li

Adrenocortical adenoma

Adrenal adenoma

10.1016/j.asjsur.2024.01.098

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Citations (0)