Thérèse Rachel Teodoro

Instituto de Assistência Médica ao Servidor Público Estadual

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Demétrius Eduardo Germini

Hospital do Servidor Público Estadual

Fernando Luiz Affonso Fonseca

Faculdade de Medicina do ABC

Jaques Waisberg

Hospital do Servidor Público Estadual

Beatriz da Costa Aguiar Alves

Faculdade de Medicina do ABC

Flávia de Sousa Gehrke

Faculdade de Medicina do ABC

Celina Tizuko Fujiyama Oshima

Universidade Federal de São Paulo

Leonardo Cardilli

Instituto do Câncer do Estado de São Paulo

Maria Aparecida da Silva Pinhal

Faculdade de Medicina do ABC

V. B. De Campos Junqueira

Maria Isete Fares Franco

Hospital São Paulo

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Faculdade de Medicina do ABC

Universidade Federal de São Paulo

Fundação do ABC

Hospital do Servidor Público Estadual

Instituto de Assistência Médica ao Servidor Público Estadual

Universidade de São Paulo

Instituto de Ciências Farmacêuticas

Hospital do Servidor Público Municipal

Hospital São Paulo

Weatherford College

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RELAÇÃO DA EXPRESSÃO DOS GENES DE RESPOSTA INFLAMATÓRIA E DOS GENES DE REPARO DE DNA COM OS ASPECTOS ANATOMOPATOLÓGICOS DO CARCINOMA COLORRETAL

Journal of Coloproctology (2018)

Demétrius Eduardo Germini Fernando Luiz Affonso Fonseca Leonardo Cardilli Thérèse Rachel Teodoro Celina Tizuko Fujiyama Oshima

10.1016/j.jcol.2018.08.271

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Detection of DNA repair protein in colorectal cancer of patients up to 50 years old can increase the identification of Lynch syndrome?

Tumor Biology (2015)

Demétrius Eduardo Germini Ana Maria Amaral Antônio Mader Luiz Guilherme Lisboa Gomes Thérèse Rachel Teodoro Maria Isete Fares Franco

The aim of this study was to compare the results of protein level of the DNA mismatch repair genes with the clinical diagnosis of Lynch syndrome according to the Amsterdam II criteria in patients 50 years and younger who underwent surgery for colorectal cancer. The subjects of analysis were 48 patients 50 years old and younger. Immunohistochemistry assays were performed to detect proteins from the DNA mismatch repair genes. Clinicopathological data and Amsterdam II criteria for the diagnosis of hereditary nonpolyposis colorectal cancer were obtained by analyzing medical records. Two (4 %) patients satisfied the Amsterdam II criteria for Lynch syndrome, and both presented levels of all of the studied mismatch repair proteins. A total of 13 (27 %) patients exhibited the absence of protein levels of the studied mismatch repair genes. None of these patients were considered suspicious for Lynch syndrome according to the Amsterdam II criteria. Screening for the level of proteins of the mismatch repair system in all colorectal cancer patients 50 years and younger can increase the identification of patients with suspicion of Lynch syndrome.

Lynch Syndrome

Microsatellite Instability

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10.1007/s13277-015-4108-5

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Profile of hMSH2 expression in breast tumors and lymph nodes: a preliminary study.

PubMed (2015)

Daniel Lourenço Lira Thérèse Rachel Teodoro Maria Aparecida da Silva Pinhal Fernando Luiz Affonso Fonseca Flávia de Sousa Gehrke

The mismatch repair (MMR) genes play a central role for the onset of cancer. One of these genes is hMSH2. A differential hMSH2 protein expression has been detected in the mononuclear fraction of peripheral blood of patients with breast cancer when compared to healthy women. This work aims to evaluate the expression of hMSH2 in patients diagnosed with breast cancer undergoing treatment at various stages of the disease to verify its potential use as a prognostic marker.Immunohistochemical expression of hMSH2 at different stages of breast cancer in 40 patients biopsy samples were analyzed.hMSH2 has a considerable increased expression in all groups of patients with tumors, when compared to patients without tumors.immunohistochemistry indeed can be a great tool for the diagnosis of breast cancer, as it is an easy and versatile technique.

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