Kodeeswaran Parameshwaran

California State University, Chico

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Vishnu Suppiramaniam

Auburn University

Muralikrishnan Dhanasekaran

Auburn University

Subramaniam Uthayathas

Howard University

Senthilkumar S. Karuppagounder

Johns Hopkins University

Thirumalini Vaithianathan

University of Tennessee Health Science Center

Carl A. Pinkert

Auburn University

Michael H. Irwin

Auburn University

Catrina Sims

Auburn University

Manal Buabeid

Ajman University

Kosta Steliou

Boston University

Cooperative Institutions

Auburn University

Walker (United States)

University of Connecticut

Texas A&M University – Commerce

University of Alabama at Birmingham

Washburn University

Tuskegee University

Emory University

Medical University of South Carolina

Johns Hopkins University

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Chronic traumatic stress impairs memory in mice: Potential roles of acetylcholine, neuroinflammation and corticotropin releasing factor expression in the hippocampus

Behavioural Brain Research (2017)

Ami Bhakta Kartheek Gavini Euitaek Yang Lani Lyman-Henley Kodeeswaran Parameshwaran

Chronic Stress

Corticotropin-releasing hormone

Anhedonia

10.1016/j.bbr.2017.08.013

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Citations (16)

Effect of dopaminergic neurotoxin MPTP/MPP+ on coenzyme Q content

Life Sciences (2008)

Muralikrishnan Dhanasekaran Senthilkumar S. Karuppagounder Subramaniam Uthayathas Loren E. Wold Kodeeswaran Parameshwaran

MPTP

Neurotoxin

10.1016/j.lfs.2008.04.016

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Citations (9)

Immunological alteration & toxic molecular inductions leading to cognitive impairment & neurotoxicity in transgenic mouse model of Alzheimer's disease

Life Sciences (2017)

Manuj Ahuja Manal Buabeid Engy A. Abdel‐Rahman Mohammed Majrashi Kodeeswaran Parameshwaran

Neurochemical

Neurotoxicity

Amyloid beta

10.1016/j.lfs.2017.03.004

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Citations (18)

Modulatory effects of dextran sulfate and fucoidan on binding and channel properties of AMPA receptors isolated from rat brain

Synapse (2006)

Vishnu Suppiramaniam Thirumalini Vaithianathan K. Manivannan Muralikrishnan Dhanasekaran Kodeeswaran Parameshwaran

Abstract Previous work showed that the glycosaminoglycan (GAG) dextran sulfate (500 kDa) altered the binding and channel properties of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA)‐type glutamate receptors. The current study compared the effects of dextran sulfate with another GAG, fucoidan (100–180 kDa), to determine whether GAG‐mediated changes in high‐affinity binding of AMPA receptors have a concomitant influence on specific channel properties. Dextran sulfate was more potent in inhibiting high‐affinity AMPA binding to solubilized receptors (EC 50 of 7 nM) compared to fucoidan (EC 50 of 124 nM). Similarly, dextran sulfate was more potent in modulating the channel properties of purified and reconstituted AMPA receptors. Dextran sulfate, at 1 μg/ml (2 nM), produced a three to fourfold increase in open channel probability and a threefold increase in mean burst duration of channel activity elicited by 283 nM AMPA. The mean open time was increased by two to threefold and closed times were decreased by two to eightfold. Fucoidan produced similar effects at a concentration many times higher than that of dextran sulfate. Dextran sulfate and fucoidan had no effect on the single channel conductance or the ability of a specific antagonist to block AMPA channels. The effects of GAGs on multichannel patches showed an interactive channel gating behavior resulting in macroscopic currents with long lived open channel life times. These findings suggest that GAG components of proteoglycans can interact with and alter the binding affinity of AMPA receptors and modulate their functional properties. Synapse 60:456–464, 2006. © 2006 Wiley‐Liss, Inc.

Fucoidan

Pregnenolone sulfate

10.1002/syn.20319

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Citations (14)

Prenatal nicotine exposure and molecular mechanisms of memory impairment

Kodeeswaran Parameshwaran

Memory Impairment

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Insulin treatment restores glutamate (α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid) receptor function in the hippocampus of diabetic rats

Journal of Neuroscience Research (2015)

Nilmini Viswaprakash Thirumalini Vaithianathan Ajitan Viswaprakash Robert L. Judd Kodeeswaran Parameshwaran

Type 1 diabetes is associated with cognitive dysfunction. Cognitive processing, particularly memory acquisition, depends on the regulated enhancement of expression and function of glutamate receptor subtypes in the hippocampus. Impairment of memory was been detected in rodent models of type 1 diabetes induced by streptozotocin (STZ). This study examines the functional properties of synaptic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptors and the expression of synaptic molecules that regulate glutamatergic synaptic transmission in the hippocampus of STZ‐diabetic rats. The AMPA receptor‐mediated miniature excitatory postsynaptic currents (mEPSCs) and single‐channel properties of synaptosomal AMPA receptors were examined after 4 weeks of diabetes induction. Results show that amplitude and frequency of mEPSCs recorded from CA1 pyramidal neurons were decreased in diabetic rats. In addition, the single‐channel properties of synaptic AMPA receptors from diabetic rat hippocampi were different from those of controls. These impairments in synaptic currents gated by AMPA receptors were accompanied by decreased protein levels of AMPA receptor subunit GluR1, the presynaptic protein synaptophysin, and the postsynaptic anchor protein postsynaptic density protein 95 in the hippocampus of diabetic rats. Neural cell adhesion molecule (NCAM), an extracellular matrix molecule abundantly expressed in the brain, and the polysialic acid (PSA) attached to NCAM were also downregulated in the hippocampus of diabetic rats. Insulin treatment, when initiated at the onset of diabetes induction, reduced these effects. These findings suggest that STZ‐induced diabetes may result in functional deteriorations in glutamatergic synapses in the hippocampus of rats and that these effects may be reduced by insulin treatment. © 2015 Wiley Periodicals, Inc.

Postsynaptic density

10.1002/jnr.23589

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Citations (15)

Long term alterations in synaptic physiology, expression of β2 nicotinic receptors and ERK1/2 signaling in the hippocampus of rats with prenatal nicotine exposure

Neurobiology of Learning and Memory (2013)

Kodeeswaran Parameshwaran Manal Buabeid Subhrajit Bhattacharya Subramaniam Uthayathas Thiruchelvam Kariharan

10.1016/j.nlm.2013.07.007

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Citations (24)

[Figure, Major principles of a Western blot. Contributed by Kartheek Gavini, MS]

Kartheek Gavini Kodeeswaran Parameshwaran

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Neurotransmitter Receptors*

Elsevier eBooks (2010)

Vishnu Suppiramaniam Engy A. Abdel‐Rahman Kodeeswaran Parameshwaran

Neurotransmitter receptor

Reuptake

Excitatory synapse

10.1016/b978-0-08-046884-6.01309-9

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Citations (1)

Selective inhibition of phosphodiesterase 5 enhances glutamatergic synaptic plasticity and memory in mice

Synapse (2013)

Subramaniam Uthayathas Kodeeswaran Parameshwaran Senthilkumar S. Karuppagounder Manuj Ahuja Muralikrishnan Dhanasekaran

Phosphodiesterases (PDEs) belong to a family of proteins that control metabolism of cyclic nucleotides. Targeting PDE5, for enhancing cellular function, is one of the therapeutic strategies for male erectile dysfunction. We have investigated whether in vivo inhibition of PDE5, which is expressed in several brain regions, will enhance memory and synaptic transmission in the hippocampus of healthy mice. We have found that acute administration of sildenafil, a specific PDE5 inhibitor, enhanced hippocampus-dependent memory tasks. To elucidate the underlying mechanism in the memory enhancement, effects of sildenafil on long-term potentiation (LTP) were measured. The level of LTP was significantly elevated, with concomitant increases in basal synaptic transmission, in mice treated with sildenafil (1 mg/kg/day) for 15 days compared to control mice. These results suggest that moderate PDE5 inhibition enhances memory by increasing synaptic plasticity and transmission in the hippocampus.

10.1002/syn.21676

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Citations (11)