L Taddei

University of Bologna

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Antonio LʼAbbate

Istituto di Fisiologia Clinica

Maria Giovanna Trivella

University of Pisa

Mario Marzilli

University of Pisa

Gualtiero Pelosi

Istituto di Fisiologia Clinica

Daniele Rovai

Istituto di Fisiologia Clinica

Paolo G. Camici

Vita-Salute San Raffaele University

D Levantesi

Marche Polytechnic University

A. Distante

Agostino Gemelli University Polyclinic

Massimo Lombardi

IRCCS Policlinico San Donato

M Dalle Vacche

University of Pisa

Cooperative Institutions

Istituto di Fisiologia Clinica

University of Pisa

National Research Council

Czech Academy of Sciences, Institute of Physiology

Fondazione Toscana Gabriele Monasterio

Istituti di Ricovero e Cura a Carattere Scientifico

National Academies of Sciences, Engineering, and Medicine

University of Bologna

Italfarmaco (Italy)

University of Bristol

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[Selective vasodilatation of the subepicardial coronary vasculature induced by carbochromen (author's transl)].

PubMed (1981)

A. LʼAbbate Maria Giovanna Trivella Paolo G. Camici Gualtiero Pelosi D Levantesi

The effect of carbochromen on total and regional coronary blood flow was investigated in 6 anesthetized open-chest dogs. Total and regional myocardial blood flow was measured by radioactive microspheres, using the reference sample method. Left circumflex coronary flow was monitored by an electromagnetic flowmeter. In 4 dogs (Group 1) carbochromen was injected intravenously; in 2 dogs (Group 2) it was infused directly in the circumflex coronary artery. No significant changes in heart rate, left atrial left ventricular and aortic pressures were observed following carbochromen administration in both Groups. Left circumflex coronary blood flow progressively increased and a level slightly higher than peak reactive hyperemia was reached in both Groups. Regional myocardial blood flow measurements in Group 1 showed that the inner third of the left ventricular wall (ENDO) increased 2.7 times relative to control, the middle layer increased 3.4 times relative to control and the external third 4.5 times relative to control. A similar pattern was observed after intracoronary administration of carbochromen (Group 2). The ENDO/EPI flow ratio dropped from 0.98 +/- 0.16 to 0.58 +/- 0.18 in Group 1 and from 1.03 and 1.20 to 0.71 and 0.53 respectively in the two experiments of Group 2. Replacement of carbochromen with adenosine infusion in Group 2 produced a further increase in flow, mainly in the subendocardium resulting in ENDO/EPI flow ratio close to unity. These data demonstrate that the powerful coronary vasodilatory effect of carbochromen is not uniform being vasodilation more prominent in the vasculature of the external third of the left ventricular wall as compared to the inner third. Consequently a major redistribution of coronary blood flow, favouring the external layers of the left ventricle, results from carbochromen administration. This effect distinguishes carbochromen from other vasodilating stimuli than elicit a uniform response in the coronary vasculature and do not affect the ENDO/EPI ratio, including transient ischemia, adenosine, and dipyridamole.

Reactive hyperemia

Circumflex

Coronary circulation

Endocardium

Coronary vasodilator

Left coronary artery

Coronary arteries

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Citations (1)

Flow quantitation by radio frequency analysis of contrast echocardiography

International journal of cardiac imaging (1993)

Daniele Rovai Massimo Lombardi A. Mazzarisi Luigi Landini L Taddei

Region of interest

Cardiac Imaging

Personal computer

SIGNAL (programming language)

10.1007/bf01142928

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Citations (15)

[Use and management of the means for the diagnostic verification of occupational pneumoconiosis].

PubMed (1979)

L Taddei

Pneumoconiosis

Interventional radiology

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Citations (0)

Physiological heterogeneity of coronary blood flow in space and time by contrast echocardiography

Developments in cardiovascular medicine (1991)

Daniele Rovai Massimo Lombardi Steven E. Nissen Mario Marzilli A. Distante

Cardiac cycle

Systole

10.1007/978-94-009-0611-2_30

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Citations (0)

Myocardial contrast washout reflects coronary blood flow in the absence of coronary autoregulation

Journal of the American College of Cardiology (1991)

Daniele Rovai Massimo Lombardi Gianna Ghelardini Maria Giovanna Trivella Edoardo Nevola

Washout

Coronary circulation

10.1016/0735-1097(91)92003-5

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Myocardial washout of sonicated iopamidol reflects coronary blood flow in the absence of autoregulation

Journal of the American College of Cardiology (1992)

Daniele Rovai Gianna Ghelardini Massimo Lombardi Maria Giovanna Trivella Edoardo Nevola

Iopamidol

Washout

Coronary circulation

Circumflex

10.1016/0735-1097(92)90257-n

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Citations (16)

[Effect of the stimulation and inhibition of beta adrenergic receptors on the contractile function and regional myocardial perfusion].

PubMed (1987)

D Levantesi Roberto Gistri Lorenzo Galletti G. Barsotti L Taddei

BETA (programming language)

Adrenergic beta-Antagonists

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Intracoronary air-filled albumin microspheres for myocardial blood flow measurement

Journal of the American College of Cardiology (1993)

Daniele Rovai Gianna Ghelardini Maria Giovanna Trivella Gunilla Björklund Edoardo Nevola

Dipyridamole

Intensity

Coronary circulation

10.1016/0735-1097(93)90792-y

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Citations (19)

Time-dependent response of coronary flow to prolonged adenosine infusion: doubling of peak reactive hyperaemic flow

Cardiovascular Research (1981)

A. LʼAbbate Paolo G. Camici Maria Giovanna Trivella Gualtiero Pelosi G. J DAVIES

In 11 anaesthetised, open chest dogs the time course and degree of the coronary vasodilating response to intracoronary adenosine infusion was assessed. Continuous adenosine infusion, at a rate of 2.5 to 13.5 μmol·min−1, produced rapid (15 to 30 s) vasodilatation of the same degree as that evoked by a 30 s period of ischaemia (reactive peak hyperaemia), a finding reported previously by others. However, continuing the infusion led to further coronary vasodilatation, reaching a maximum 20 to 45 min from the beginning of the infusion and remaining constant for up to 2 h, independently of further increases in the dose. This late response produced, on average, vasodilatation twice as great as that observed during reactive hyperaemia and was not associated with any haemodynamic change or with the opening of arterio-venous shunts. The results: 1) suggest the existence of a double, time-dependent response of coronary receptor(s) to adenosine; 2) demonstrate, in the presence of a prolonged vasodilating stimulus, a possible increase in coronary blood flow to a degree far beyond that of post-ischaemic reactive peak flow, which is generally considered to be the maximal value of coronary blood flow that can be achieved.

Hyperaemia

Reactive hyperemia

Coronary vasodilator

Coronary circulation

10.1093/cvr/15.5.282

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Citations (18)

[Evaluation of the chest roentgenograms of 90 workers employed in the production of silicon-alloys (author's transl)].

PubMed (1979)

L Taddei Andrea Cristofolini D Bradamante

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Citations (3)