Die Hu

In an attempt to find the biorational pesticides, 20 novel chalcone derivatives containing a piperazine fragment were designed and synthesized. Their fungicidal activities and preliminarily action mechanism against Rhizoctonia solani were evaluated. Strikingly, the biological activity of compound D2 was obtained by optimizing the structure of the system. Subsequently, the practical value of compound D2 was ascertained by the relative surveys on in vivo anti-R. solani and anti-Colletotrichum gloeosporioides. The results revealed by scanning electron microscopy demonstrated that compound D2 could induce irregular and shrivelled growth of mycelium and rupture of the mycelium surface. This study indicates that chalcone derivatives containing a piperazine skeleton had better inhibitory effect on plant fungi, providing further complementary research on new pesticides.

Piperazine

Chalcone

Chemical structure

10.1021/acs.jafc.1c05933

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Citations (59)

Synthesis and biological activities of novel chalcone derivatives containing pyrazole oxime ethers

Fitoterapia (2023)

Die Hu Nian Zhang Qing Zhou Yuanxiang Zhou Chenyu Gong

Pyrazole

Microscale Thermophoresis

Chalcone

EC50

Docking (animal)

10.1016/j.fitote.2023.105458

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Citations (13)

The Leaves of Cyclocarya paliurus: A Functional Tea with Preventive and Therapeutic Potential of Type 2 Diabetes

The American Journal of Chinese Medicine (2022)

Miao Qiu Jiao Peng Huan Deng Yaoyao Chang Die Hu

Type 2 diabetes mellitus (T2DM) has become a universal and chronic global public health concern and causes multiple complex complications. In order to meet the rapidly growing demand for T2DM treatment, increased research has been focused on hypoglycemic drugs. Cyclocarya paliurus (Batal.) Iljinsk is the only living species of the genus Cyclocarya Iljinskaja, whose leaves have been extensively used as a functional tea to treat obesity and diabetes in China. An enormous amount of very recent pharmacological research on the leaves of C. paliurus has demonstrated that they carry out numerous biological activities, such as hypoglycemic, anti-inflammatory, and intestinal microbiota regulation. Multiple in vitro and in vivo studies have also shown that the extracts of C. paliurus leaves are innocuous and safe. This study aims to provide an up-to-date review of the botany, traditional uses, phytochemistry, pharmacological effects against diabetes, toxicology, and clinical studies of C. paliurus leaves, in hopes of promoting a better understanding of their role in the prevention and treatment of T2DM.

Phytotherapy

10.1142/s0192415x22500628

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Citations (6)

Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of (R)-1,2-diols from racemic epoxides

Chemical Communications (2020)

Die Hu Xun-Cheng Zong Feng Xue Chuang Li Bo-Chun Hu

Both the activity and regioselectivity of Phaseolus vulgaris epoxide hydrolase were remarkably improved via reshaping two substrate tunnels based on rational design.

Epoxide hydrolase 2

Biocatalysis

10.1039/d0cc00283f

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Citations (27)

Spatial dynamics of biochemical fractions degradation, functional enzymatic activity and bacterial community within co-bioevaporation pile

Journal of Cleaner Production (2020)

Benqin Yang Zhiqiang Lin Yanmei Liu Die Hu Xiandong Zhou

Mesophile

Degradation

Biogeochemical Cycle

Extremophile