Zuzana Michálková

Masaryk University

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Michal Dufek

Masaryk University

Irena Rektorová

Masaryk University

Ivan Rektor

Central European Institute of Technology – Masaryk University

David Goldemund

McMaster University

Kateřina Sheardová

St. Anne's University Hospital Brno

Petr Bednařík

Amager Hospital

J Lokaj

Masaryk University

Sabina Telecká

Central European Institute of Technology

Markéta Hamanová

BioVendor (Czechia)

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University Hospital Brno

Masaryk University

St. Anne's University Hospital Brno

Central European Institute of Technology

International Clinical Research Center, St. Anne's University Hospital Brno

Central European Institute of Technology – Masaryk University

Central European Institute of Technology

University of Vienna

Inserm

Université de Lille

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Answer to Letter to the Editor: Vascular risk factors do not contribute to motor and cognitive impairment in Parkinson's Disease by Dr Sławek et al.

Parkinsonism & Related Disorders (2009)

Ivan Rektor David Goldemund Kateřina Sheardová Irena Rektorová Zuzana Michálková

10.1016/j.parkreldis.2009.07.004

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Vascular pathology in patients with idiopathic Parkinson's disease

Parkinsonism & Related Disorders (2008)

Ivan Rektor David Goldemund Kateřina Sheardová Irena Rektorová Zuzana Michálková

Subclinical infection

10.1016/j.parkreldis.2008.02.007

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Citations (62)

Impairment of brain vessels may contribute to mortality in patients with Parkinson's disease

Movement Disorders (2012)

Ivan Rektor David Goldemund Petr Bednařík Kateřina Sheardová Zuzana Michálková

Abstract Background: The effect of brain‐vessel pathology on mortality in 57 consecutive PD patients was studied. Methods: Baseline clinical, neuropsychological, ultrasonographic (US), and MR data obtained from patients who died (n = 18) during a 4‐year follow‐up period were compared with the data of patients who survived. Results: US/MRI data displayed a more‐severe vascular impairment in deceased patients. Differences were significant between both groups with respect to age, clinical and cognitive status, intima‐media thickness, and resistance index (indicators of large and small vessel impairment). The sum score of white‐matter hyperintensities was significantly higher among decedents. A cluster analysis displayed two clusters that differed in the two parameters (i.e. in age and in sum score). Conclusions: This study provides evidence that comorbid atherosclerosis and otherwise subclinical impairment of brain vessels may contribute to mortality in PD. The vascular pathology may act in association with other comorbidities on the terrain of progressive neurodegenerative pathology. © 2012 Movement Disorder Society

Subclinical infection

10.1002/mds.25066

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Citations (26)

Vascular factors contribute to motor and cognitive dysfunction and mortality in Parkinson'/INS;s disease

Journal of the Neurological Sciences (2013)

Ivan Rektor David Goldemund Petr Bednařík Kateřina Sheardová Zuzana Michálková

Motor dysfunction

10.1016/j.jns.2013.07.523

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Serum inflammatory biomarkers in Parkinson's disease