Małgorzata Janicka‐Jedyńska

Poznan University of Medical Sciences

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Marek Ruchała

Poznan University of Medical Sciences

Katarzyna Ziemnicka

Poznan University of Medical Sciences

Ewelina Szczepanek‐Parulska

Poznan University of Medical Sciences

Szymon Dębicki

Poznan University of Medical Sciences

Bartłomiej Budny

Poznan University of Medical Sciences

Martyna Borowczyk

Poznan University of Medical Sciences

Aldona Woźniak

Poznan University of Medical Sciences

Elżbieta Wrotkowska

Poznan University of Medical Sciences

Dorota Filipowicz

Poznan University of Medical Sciences

Barbara Więckowska

Poznan University of Medical Sciences

Cooperative Institutions

Poznan University of Medical Sciences

Heliodor Swiecicki Clinical Hospital

Centrum Onkologii

Université Paris Cité

Inserm

Greater Poland Cancer Center

University of Turin

Assistance Publique – Hôpitaux de Paris

University of Life Sciences in Poznań

Central Clinical Hospital

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Endoscopical and histological aspects of inflammatory changes in J-pouch mucosa.

PubMed (2000)

Ryszard Marciniak P Majewski M Drews Piotr Krokowicz M de Lange

The aim of the study was endoscopic and histological evaluation of mucosal inflammatory changes in the ileal reservoir after restorative proctocolectomy with ileoanal anastomosis (IPAA) because of FAP (27 patients) and ulcerative colitis (34 patients). Endoscopic symptoms of pouchitis (edema, granularity, contact bleeding, loss of vascular pattern, mucus, erosions) were found in 13 patients (4 were operated on because of FAP, 9 because of UC). A statistically significant difference (p < 0.0001) was found between endoscopic inflammatory index in UC (4.0 +/- 0.5) and in FAP (1.00 +/- 0.00). The endoscopic changes were correlated with the Moskowitz histological classification, in 12 acute score and in 6 chronic score were above 4 points. In 18 patients histological diagnosis of pouchitis was made (5 in FAP, 13 in UC). Acute pouchitis occurred in 12 patients and chronic in 6. In one patient histological changes resembled Crohn's disease. Regular endoscopic control with histological examination and verification of inflammatory lesions in the ileal reservoir is necessary.

Pouchitis

Proctocolectomy

Pouch

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Citations (5)

A case of late breast cancer metastases to both suprarenal glands 28 years after mastectomy

Hereditary Cancer in Clinical Practice (2012)

Tomasz Banasiewicz Łukasz Krokowicz M. Biczysko Małgorzata Janicka‐Jedyńska Andrzej Pławski

We present an extremely rare case of late metastases of breast cancer to both suprarenal glands 28 years after mastectomy. The patient originally underwent Patey’s radical mastectomy of the left breast. In the follow-up, metastases were detected in the skin of the thorax and labia majora and were subsequently resected. During the most recent hospitalization metastases to both adrenal glands were detected (PET-CT, MRI) and removed. In genetic examination the entire coding sequences of BRCA1 and BRCA2 gene were screened for mutation by direct PCR product sequencing as described before by Gorski et al. No BRCA1 and BRCA2 gene mutations were found. Histological examination revealed breast cancer metastasis to the adrenal glands. In our opinion our case can be the latest described metastases of breast cancer. The described case was an early stage of primary cancer (T1N0M0). Patients after breast cancer resection should still be followed up for late metastases. Late metastases including atypical sites should always be suspected regardless of time from initial presentation. The correlations between mutation and metastases of breast cancer needs to be discussed.

Labia majora

10.1186/1897-4287-10-s3-a1

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High incidence of FLT3 mutations in follicular thyroid cancer: potential therapeutic target in patients with advanced disease stage

Therapeutic Advances in Medical Oncology (2020)

Martyna Borowczyk Ewelina Szczepanek‐Parulska Szymon Dębicki Bartłomiej Budny Małgorzata Janicka‐Jedyńska

Background: Conventional treatments for follicular thyroid cancer (FTC) can be ineffective, leading to poor prognosis. The aim of this study was to identify mutations associated with FTC that would serve as novel molecular markers of the disease and its outcome and could potentially identify new therapeutic targets. Methods: FLT3 mutations were first detected in a 29-year-old White female diagnosed with metastasized, treatment-refractory FTC. Analyses of FLT3 mutational status through next-generation sequencing of formalin-fixed, paraffin-embedded FTC specimens were subsequently performed in 35 randomly selected patients diagnosed with FTC. Results: FLT3 mutations were found in 69% of patients. FLT3 mutation-positive patients were significantly older than those that were FLT3 mutation-negative [median age at diagnosis 54 (36–82) versus 45 (27–58) ( p = 0.023)]. Patients over 60 years were 23 times more likely to be FLT3 mutation-positive ( p = 0.006). However, the number of FLT3 mutations did not correlate with age ( r-Pearson: –0.244, p-value: 0.25). A total of 26 mutations were identified in the FLT3 gene with 2–16 FLT3 mutations in each FLT3 mutation-positive patient (mean: 5.6 mutations/patient). Tyrosine kinase domain (TKD) mutations in the FLT3 gene were detected in 58% of FLT3 mutation-positive patients. All FLT3 mutation-positive patients with a disease stage of pT2N1 or worse harbored at least one mutation in the TKD of FLT3. Conclusions: There is a wide spectrum and high frequency of FLT3 mutations in FTC. The precise role of FLT3 mutations in the genesis of FTC, as well as its potential role as a therapeutic target, requires further investigation.

10.1177/1758835920907534

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Follicular Thyroid Adenoma and Follicular Thyroid Carcinoma—A Common or Distinct Background? Loss of Heterozygosity in Comprehensive Microarray Study

Cancers (2023)

Martyna Borowczyk Paula Dobosz Ewelina Szczepanek‐Parulska Bartłomiej Budny Szymon Dębicki

Pre- and postsurgical differentiation between follicular thyroid adenoma (FTA) and follicular thyroid cancer (FTC) represents a significant diagnostic challenge. Furthermore, it remains unclear whether they share a common or distinct background and what the mechanisms underlying follicular thyroid lesions malignancy are. The study aimed to compare FTA and FTC by the comprehensive microarray and to identify recurrent regions of loss of heterozygosity (LOH). We analyzed formalin-fixed paraffin-embedded (FFPE) samples acquired from 32 Caucasian patients diagnosed with FTA (16) and FTC (16). We used the OncoScan™ microarray assay (Affymetrix, USA), using highly multiplexed molecular inversion probes for single nucleotide polymorphism (SNP). The total number of LOH was higher in FTC compared with FTA (18 vs. 15). The most common LOH present in 21 cases, in both FTA (10 cases) and FTC (11 cases), was 16p12.1, which encompasses many cancer-related genes, such as TP53, and was followed by 3p21.31. The only LOH present exclusively in FTA patients (56% vs. 0%) was 11p11.2-p11.12. The alteration which tended to be detected more often in FTC (6 vs. 1 in FTA) was 12q24.11-q24.13 overlapping FOXN4, MYL2, PTPN11 genes. FTA and FTC may share a common genetic background, even though differentiating rearrangements may also be detected.

Follicular thyroid cancer

Tissue microarray

10.3390/cancers15030638

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Citations (3)

Comparison between high‐frequency ultrasonography (Dermascan C, version 3) and histopathology in atopic dermatitis

Skin Research and Technology (2013)

Adriana Polańska Aleksandra Dańczak‐Pazdrowska Wojciech Silny Aldona Woźniak Konstantin Maksin

Background The main purpose of this study was the exact comparison of B‐scan images obtained from 16 patients suffering from AD with histological. Methods Sixteen patients diagnosed with AD aged between 14 and 57 years, were chosen for the study. In all patients before the introduction of proper treatment regimen, the high frequency skin ultrasonography (Derma Scan Cortex Technology, version 3, Hadsund, Germany) has been performed and then a 5 mm wide punch biopsies have been taken from the area of scanned lesions. Control group consisted of 15 healthy individuals without any signs of atopic and chronic diseases. Results There was 7.8 ± 0.4% mean skin echogenicity from lesional antecubital skin in AD patients (min value 7.2%, max value 8.5%). The skin hypoechoic band was detected in fifteen out of sixteen patients (93.7%). There were statistically significant correlations between the hypoechoic band thickness and the following parameters: degree of epidermal hyperplasia, the degree of epidermal hyperkeratosis, the degree of parakeratosis and the degree of spongiosis as well as the intensity of inflammatory infiltrates. Skin echogenicity strongly correlated negatively with the intensity of inflammatory infiltrates. Conclusion On the basis of analysis of 16 specimens we can conclude that all pathological changes of AD influence ultrasound image and in addition, the USG picture depends on the phase of disease process.

Echogenicity

Parakeratosis

Spongiosis

Histopathology

10.1111/srt.12064

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Citations (54)

Usefulness of immunohistochemical testing and electron microscopy in the diagnosis of embryonal rhabdomyosarcoma.

PubMed (2002)

W Biczysko Aldona Woźniak W Salwa-Żurawska Małgorzata Janicka‐Jedyńska E Trejster

This article presents the results of histological, immunohistochemical, and ultrastructural examinations of embryonal rhabdomyosarcoma.20 tumors were tested histologically, 13 immunohistochemically, and 5 under electron microscopy.We found that in cases when the entire tumor or large specimens were obtained for estimation, it was possible by examining many areas of the neoplasm to establish a diagnosis on the basis of testing paraffined sections, routinely HE stained. Our evaluation of the value of certain additional histological methods indicated only slight diagnostic usefulness for tumors of this kind. Among the immunohistochemical methods we evaluated, the desmin assay had the greatest practical applicability, due to the fact that this antigen is also expressed in highly immature cells; in second place was myoglobin. Differences are pointed out in the results obtained by assaying myoglobin using DAB and the DAKO kit. Ultrastructural examinations revealed myofilaments of myosin and actin in all types of cells, including immature cells. Particular attention is drawn to the possibility of using material fixed in formalin for ultrastructural examination. The preservation of intact myofilaments in material prepared in this way constitutes an essential diagnostic aid.In diagnosing embryonal rhabdomyosarcoma the most useful examination, apart from histological examination, is electron microscopy, followed by immunomorphological examination.

Desmin

Myofilament

Embryonal rhabdomyosarcoma

Neoplasm

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Citations (1)

TP53 and FLT3 may become candidate markers for detecting malignancy in follicular lesions

Endocrine Abstracts (2019)

Martyna Borowczyk Ewelina Szczepanek‐Parulska Szymon Dębicki Bartłomiej Budny Frederik A. Verburg

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

10.1530/endoabs.63.p1204

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Electron-microscopic and Immunohistochemical Study in Henoch-Schoenlein Nephritis

Ultrastructural Pathology (2013)

Aldona Woźniak Katarzyna Pluta-Hadas Jakub Żurawski Małgorzata Janicka‐Jedyńska Elżbieta Kaczmarek

Henoch-Schoenlein nephritis (HSN) is the most common secondary childhood nephropathy, leading to end-stage renal disease in up to 20% of pediatric patients after long-term follow-up. Forty-four cases of HSN were reviewed (32 children, 12 adults). Electron microscopy (EM) was performed in 7 cases and immunohistochemistry for Ki-67, PCNA, and p27 in all. Light microscopy: grade II (18), III (15), IV (3), and VI (8). Glomerulosclerosis and interstitial fibrosis were important prognostic markers and coexisted with poor outcome. EM was performed mainly in grade VI and was useful in recognition of early glomerulosclerosis. No correlations were found between the Ki67 and PCNA mesangial expression and outcome. Progressive decrease in p27 podocyte expression was noted with more severe HSN grades.

Nephritis

Glomerulosclerosis

10.3109/01913123.2012.670035

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Citations (9)

The Usefulness of Standardized Uptake Value in Differentiation between Benign and Malignant Thyroid Lesions Detected Incidentally in 18F-FDG PET/CT Examination

PLoS ONE (2014)

Adam Stangierski Kosma Woliński Rafał Czepczyński Agata Czarnywojtek Martha Lodyga

Introduction In the last decade, (18)F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET and PET/CT) has become one of the major diagnostic tools used in oncology. A significant number of patients who undergo this procedure, due to non-thyroidal reasons, present incidental uptake of (18F-FDG) in the thyroid. The aim of the study was to compare the SUVmax (standardized uptake value) of thyroid focal lesions, which were incidentally found on PET/CT, in relation to the results of thyroid fine-needle aspiration biopsy (FNAB) and/or histopathological evaluation. Materials and Methods Patients referred for PET/CT examination, due to non-thyroidal illness, presented focal 18F-FDG uptake in the thyroid and were advised to undergo ultrasonography (US), hormonal evaluation, FNAB and/or total thyroidectomy at our institution. Results 6614 PET/CT examinations performed in 5520 patients were analyzed. Of the 122 patients with focal thyroid 18F-FDG activity, 82 patients (67.2%) underwent further thyroid evaluation using FNAB. Benign lesions were diagnosed in 46 patients, malignant - in 19 patients (confirmed by post-surgical histopathology), while 17 patients had inconclusive results of cytological assessment. Mean SUVmax of benign lesions was 3.2±2.8 (median = 2.4), while the mean SUVmax value for malignant lesions was 7.1±8.2 (median = 3.5). The risk of malignancy was 16.7% for lesions with a SUVmax under 3, 43.8% for lesions with a SUVmax between 3 and 6, and 54.6% for lesions with a SUVmax over 6. In the group of malignant lesions, a positive correlation between the lesion's diameter and SUVmax was observed (p = 0.03, r = 0.57). Conclusions Subjects with incidental focal uptake of 18F-FDG in thyroid are at a high risk of thyroid malignancy. A high value of SUVmax further increases the risk of malignancy, indicating the necessity for further cytological or histological evaluation. However, as SUVmax correlated with the diameter of malignant lesions, small lesions with focal uptake of 18F-FDG should be interpreted cautiously.

Standardized uptake value

Histopathology

PET-CT

Fluorodeoxyglucose

Incidentaloma

10.1371/journal.pone.0109612

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Citations (28)

Role of Different Variants of Leptin Receptor in Human Adrenal Tumor Types

International Journal of Molecular Sciences (2024)

Anna Klimont Marcin Ruciński Nadia Sawicka‐Gutaj Marta Szyszka Małgorzata Blatkiewicz

The aim of the study was to evaluate the diagnostic and prognostic significance of leptin receptor isoforms in adrenal tumors. In a single-center study, 96 patients (19 with adrenal cortical carcinoma and 77 with benign tumors) underwent an adrenalectomy. A total of 14 unaffected adrenal gland tissues from kidney donors were used as controls. Fasting blood samples were collected for laboratory tests, and mRNA expressions of leptin receptor isoforms were assessed by RT-qPCR. The study analyzed correlations between mRNA expressions and clinical data and measured NCI-H295R cell proliferation via a real-time cell analyzer. All adrenal lesions expressed leptin receptor isoforms. Significantly lower LepR1 expression was observed in carcinoma tissues than in adenomas and controls (

10.3390/ijms25168682

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