Adilson Paulo Sinhorin

Research Field

The objective of this work was to evaluate the chemoprotective effects of the embaúba Cecropia distachya Huber (two methanolic fractions: F1 and F2) on oxidative stress induced by cyclophosphamide (75 mg kg-1) in mice, as well as phytochemical analyzes by LC-MS/MS. In the experimental model, the fractions increased the hepatic and cardiac catalase (CAT), reduced glutathione (GSH) of the kidney and the heart. F1 increased platelet levels (PLT), hemogram (RBC), hematocrit (HCT) and hemoglobin (Hb) and F1 reduced hepatic lipid peroxidation (TBARS) and aspartate aminotransferase (AST) activity increased. F1 was attributed to possible hypoglycemic activity and possible immunosuppressive effects and F2 presented antimutagenic activity. In some cases, the fractions were also hepatotoxic. These results demonstrated that the fractions stimulate the antioxidant defenses, being hypoglycemic (F1) and antimutagenic (F2), and, the harmful effects attributed to the fractions may be the association of compounds that were not elucidated in this work.

Chemoprotective

TBARS

10.21664/2238-8869.2020v9i2.p103-127

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Citations (6)

1,1,1-Trichloro-4,4-diethoxy-3-buten-2-one and Its Trichloroacetylacetate Derivatives: Synthesis and Applications in Regiospecific Preparation of Azoles.

ChemInform (2004)

Marcos A. P. Martins Cláudio M. P. Pereira Nilo E. K. Zimmermann Sidnei Moura Adilson Paulo Sinhorin

Abstract For Abstract see ChemInform Abstract in Full Text.

10.1002/chin.200411074

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Biochar increases the sorption and reduces the potential leaching the diuron in sandy soil.

Fabiano André Petter Tamara Santos Ferreira Adilson Paulo Sinhorin Larissa Borges de Lima Fernandes Antônio de Almeida

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Evaluation of the antioxidant potential of Copaifera multijuga in Ehrlich tumor-bearing mice

Acta Amazonica (2018)

Ana Paula Simões da Cunha Luana Baldissera Débora Linsbinski Pereira Lucinéia Reuse Albiero Lindsey Castoldi

ABSTRACT Copaifera multijuga, commonly known as copaiba, is popularly used in the form of tea for various conditions due to the presence of antioxidant substances in its composition, which protect cells against damage caused by free radicals. Its oleoresin is also used as an anti-inflammatory and antitumoral agent. The present study investigated the antioxidant effect of the ethanolic extract of copaiba stem bark on Swiss mice inoculated with solid Ehrlich tumors. Mice were inoculated subcutaneously with 1x106 Ehrlich’s tumor cells and treated via gavage with ethanolic extract of copaiba for thirty days, with doses varying between 100 and 200 mg kg-1. Biochemical analyses of enzymatic antioxidants [superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST)], non-enzymatic antioxidants [reduced glutathione (GSH) and ascorbic acid (ASA)], substances reactive to thiobarbituric acid (TBARS) and protein carbonylation (carbonyl) in different tissues were significantly affected. The extract administered at 200 mg kg-1 presented higher antioxidant capacity in the liver, increased CAT, GST, GSH and decreased TBARS, as well as increased CAT activity and protein carbonylation in brain tissue. The results showed that the copaiba extract was able to reverse the oxidative stress caused by solid Ehrlich tumor, probably due to the presence of antioxidant compounds, and had potential antineoplasic effect after a 30-day treatment.

TBARS

Thiobarbituric acid

10.1590/1809-4392201800672

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Citations (8)

Effects of the acute exposition to glyphosate-based herbicide on oxidative stress parameters and antioxidant responses in a hybrid Amazon fish surubim (Pseudoplatystoma sp)

Ecotoxicology and Environmental Safety (2014)

Valéria Dornelles Gindri Sinhorin Adilson Paulo Sinhorin Jhonnes Marcos dos Santos Teixeira Kelly Márcia Lazarotto MILÉSKI Paula Carine Hansen

TBARS

Thiobarbituric acid

10.1016/j.ecoenv.2014.04.040

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Citations (102)

New glycosylated biscoumarins from Hymenaea coubaril L. seeds

Phytochemistry Letters (2015)

Hocelayne Paulino Fernandes Adilson Paulo Sinhorin Valéria Dornelles Gindri Sinhorin Gerardo Magela Vieira Júnior Virgínia Cláudia da Silva

10.1016/j.phytol.2015.07.016

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Citations (10)

Metabolic and Behavior Changes in Surubim Acutely Exposed to a Glyphosate-Based Herbicide

Archives of Environmental Contamination and Toxicology (2014)

Valéria Dornelles Gindri Sinhorin Adilson Paulo Sinhorin J. M. S. Teixeira Kelly Márcia Lazarotto MILÉSKI Paula Carine Hansen

10.1007/s00244-014-0073-z

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Citations (32)

Correction: Patias et al. Effect of Liposomal Protium heptaphyllum (Alb.) March Extract in the Treatment of Obesity Induced by High-Calorie Diet. Biology 2024, 13, 535

Biology (2024)

Naiéle Sartori Patias Eveline Aparecida Isquierdo Fonseca de Queiroz Stela Regina Ferrarini Gisele Facholi Bomfim Danilo Henrique Aguiar

In the original publication [...]

Low calorie diet

10.3390/biology13100833

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HALOACETYLATED ENOL ETHERS. XVII.1* A CONVENIENT SYNTHESIS OF 5-TRICHLOROMETHYL-1,2-DIMETHYL- 1H-PYRAZOLIUM CHLORIDES

Synthetic Communications (2002)

Marcos A. P. Martins Cláudio M. P. Pereira Adilson Paulo Sinhorin Giovani P. Bastos Nilo E. K. Zimmermann

ABSTRACT The one-pot synthesis of nine 5-trichloromethyl-1,2-dimethyl-1H-pyrazolium chlorides 2 from the cyclocondensation of 4-alkoxy-1,1,1-trichloro-3-alken-2-ones [CCl3C(O)C(R2)= C(R1)OR, where R1 = H, Me, Et, n-Pr, (CH2)5CO2Et, CH2Br, Ph, 4-Br-C6H4; R2 = H, Me; and R = Me, Et] with 1,2-dimethylhydrazine is reported. For Part 16, see Ref. [12].

10.1081/scc-120002126

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Citations (28)

Oxidative stress in the hybrid fish jundiara (Leiarius marmoratus × Pseudoplatystoma reticulatum) exposed to Roundup Original®

Chemosphere (2017)

Fernando Rafael de Moura Kamila Ribeiro Brentegani Aline Gemelli Adilson Paulo Sinhorin Valéria Dornelles Gindri Sinhorin

TBARS

Thiobarbituric acid

Neurotoxicity

10.1016/j.chemosphere.2017.07.030

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Citations (65)