Ana Marta Pereira

Universidade do Porto

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i-10 index

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Document Type

Co-Authors

Marta Guimarães

Universidade do Porto

Mário Nora

Centro Hospitalar de Entre o Douro e Vouga E.P.E.

Raquel Seiça

University of Coimbra

Mariana P. Monteiro

Universidade do Porto

Sofia S. Pereira

Universidade do Porto

J Marques-Antunes

Centro Hospitalar de Entre o Douro e Vouga E.P.E.

Cristina M. Sena

University of Coimbra

M. Nora

Centro Hospitalar de Entre o Douro e Vouga E.P.E.

P Correia

Instituto Português de Oncologia de Coimbra Francisco Gentil

Jane Yu

University of Auckland

Cooperative Institutions

Harvard University

Brigham and Women's Hospital

Centro Hospitalar de Entre o Douro e Vouga E.P.E.

Universidade do Porto

University of Coimbra

Weatherford College

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto

Centre National de la Recherche Scientifique

Bellvitge University Hospital

Administração Regional de Saúde de Lisboa e Vale do Tejo

Author Statistics

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Different Malabsorptive Obesity Surgery Interventions Result in Distinct Postprandial Amino Acid Metabolomic Signatures

Obesity Surgery (2020)

Sofia S. Pereira Ivana Jarak Rui A. Carvalho Pedro F. Oliveira Marco G. Alves

Sleeve gastrectomy

Biliopancreatic Diversion

Isoleucine

Duodenal switch

10.1007/s11695-020-04774-z

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Citations (5)

Adiponectin improves endothelial function in mesenteric arteries of rats fed a high‐fat diet: role of perivascular adipose tissue

British Journal of Pharmacology (2017)

Cristina M. Sena Ana Marta Pereira Rosa Fernandes Liliana Letra Raquel Seiça

Adiponectin, the most abundant peptide secreted by adipocytes, is involved in the regulation of energy metabolism and vascular physiology. Here, we have investigated the effects of exogenous administration of adiponectin on metabolism, vascular reactivity and perivascular adipose tissue (PVAT) of mesenteric arteries in Wistar rats fed a high-fat diet.The effects of adiponectin on NO-dependent and independent vasorelaxation were investigated in isolated mesenteric arteries from 12-month-old male Wistar rats (W12m) fed a high-fat diet (HFD) for 4 months and compared with those from age-matched rats given a control diet. Adiponectin ((96 μg·day-1 ) was administered by continuous infusion with a minipump, implanted subcutaneously, for 28 days.Chronic adiponectin treatment reduced body weight, total cholesterol, free fatty acids, fasting glucose and area under the curve of intraperitoneal glucose tolerance test, compared with HFD rats. It also normalized NO-dependent vasorelaxation increasing endothelial NO synthase (eNOS) phosphorylation in mesenteric arteries of HFD rats. In PVAT from aged (W12m) and HFD rats there was increased expression of chemokines and pro-inflammatory adipokines, the latter being important contributors to endothelial dysfunction. Infusion of adiponectin reduced these changes.Adiponectin normalized endothelial cell function by a mechanism that involved increased eNOS phoshorylation and decreased PVAT inflammation. Detailed characterization of the adiponectin signalling pathway in the vasculature and perivascular fat is likely to provide novel approaches to the management of atherosclerosis and metabolic disease.This article is part of a themed section on Molecular Mechanisms Regulating Perivascular Adipose Tissue - Potential Pharmacological Targets? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.20/issuetoc.

Mesenteric arteries

Endothelial Dysfunction

10.1111/bph.13756

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Citations (78)

Endothelial dysfunction — A major mediator of diabetic vascular disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2013)

Cristina M. Sena Ana Marta Pereira Raquel Seiça

Endothelial Dysfunction

10.1016/j.bbadis.2013.08.006

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Citations (742)

p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis

Cancer Research (2017)

Hilaire C. Lam Christian V. Baglini Alicia Llorente Lope Andrey A. Parkhitko Heng-Jia Liu

p62/sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate that accumulates in cells with hyperactive mTORC1, such as kidney cells with mutations in the tumor suppressor genes tuberous sclerosis complex (TSC)1 or TSC2. Here we report that p62 is a critical mediator of TSC2-driven tumorigenesis, as Tsc2

Sequestosome 1

TSC2

Mediator

10.1158/0008-5472.can-16-2458

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Citations (51)

ECM-enriched alginate hydrogels for bioartificial pancreas: an ideal niche to improve insulin secretion and diabetic glucose profile

Journal of Applied Biomaterials & Functional Materials (2019)

Joana Crisóstomo Ana Marta Pereira Sílvia J. Bidarra Ana Cristina Gonçalves Pedro L. Granja

The success of a bioartificial pancreas crucially depends on ameliorating encapsulated beta cells survival and function. By mimicking the cellular in vivo niche, the aim of this study was to develop a novel model for beta cells encapsulation capable of establishing an appropriate microenvironment that supports interactions between cells and extracellular matrix (ECM) components.ECM components (Arg-Gly-Asp, abbreviated as RGD) were chemically incorporated in alginate hydrogels (alginate-RGD). After encapsulation, INS-1E beta cells outcome was analyzed in vitro and after their implantation in an animal model of diabetes.Our alginate-RGD model demonstrated to be a good in vitro niche for supporting beta cells viability, proliferation, and activity, namely by improving the key feature of insulin secretion. RGD peptides promoted cell-matrix interactions, enhanced endogenous ECM components expression, and favored the assembly of individual cells into multicellular spheroids, an essential configuration for proper beta cell functioning. In vivo, our pivotal model for diabetes treatment exhibited an improved glycemic profile of type 2 diabetic rats, where insulin secreted from encapsulated cells was more efficiently used.We were able to successfully introduce a novel valuable function in an old ally in biomedical applications, the alginate. The proposed alginate-RGD model stands out as a promising approach to improve beta cells survival and function, increasing the success of this therapeutic strategy, which might greatly improve the quality of life of an increasing number of diabetic patients worldwide.

Cell therapy

Cell encapsulation

10.1177/2280800019848923

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Citations (16)

Translocation (8;17;15;21)(q22;q23;q15;q22) in acute myeloid leukemia (M2)

Cancer Genetics and Cytogenetics (2001)

Luı́s Vieira Vanessa G. Oliveira Ana Paula Ambrósio Bárbara Marques Ana Marta Pereira

Derivative chromosome

Fusion transcript

Breakpoint

10.1016/s0165-4608(01)00404-6

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Citations (41)

Adenomyomatous Hyperplasia of Ampulla of Vater and a Concomitant Renal Tumor: A Case Report

Cureus (2021)

Luísa Frutuoso Ana Marta Pereira Lucia Carvalho Gil Gonçalves Mário Nora

Adenomyomatous hyperplasia is an extremely rare lesion encountered in the ampulla of Vater. Less than 50 cases have been described, most of them with clinical consequences of biliary obstruction, misdiagnosing it as a malignancy. The authors present a concomitant case with a renal tumor, its diagnosis, management, and clinical relevance, as well as a brief revision of the literature. Ampullar and renal tumors were found in a 74-year-old female, in the imagiologic study of a low back pain, in the emergency department. Both were considered malign after further study, and pancreatoduodenectomy with partial nephrectomy was proposed. There is no accurate diagnostic tool to differentiate the benign nature of adenomyomatous hyperplasia and extensive operations are often performed. As an incidental finding in the study of another tumor, this case raises the concern about which and how to treat both tumors, taking into account the morbidity of the respective interventions.

Concomitant

Ampulla of Vater

10.7759/cureus.20258

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Citations (2)

Adjuvant Botulinum Toxin Type A on the Management of Giant Hiatal Hernia: A Case Report

Cureus (2024)

Catarina D Henriques Egon F Rodrigues Lucia Carvalho Ana Marta Pereira Mário Nora

The management of giant hiatal hernias (HHs) remains challenging and is associated with a high risk of recurrence. Currently, several strategies are used to reduce recurrence, and a newly proposed trend is the administration of adjuvant botulinum toxin type A (BTX), a procedure already performed in complex ventral hernias. Here, we present a case of a 63-year-old man with a giant paraesophageal HH type IV containing the entire stomach and transverse colon with loss of domain, who underwent adjuvant BTX and subsequently laparoscopic hiatoplasty with a biological mesh with partial fundoplication. At six months’ follow-up, the patient reported a significant improvement in the quality of life without dysphagia or gastroesophageal reflux and with a good respiratory function. A control computed tomography was performed, which documented a partial recurrence of HH, completely asymptomatic. This clinical case showed the successful treatment of a giant HH using adjuvant BTX injection to increase abdominal wall compliance as had already been described in the treatment of complex ventral hernia. Thus, the use of BTX is a promising strategy for selected cases of giant HHs mainly if there is a loss of domain; however, more case series and controlled trials are needed to show the reproducibility of the benefit of this strategy.

Hiatal Hernia

Adjuvant Therapy

10.7759/cureus.53836

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Citations (0)

Hepatic Actinomycosis Mimicking Malignancy After Pancreaticoduodenectomy: A Case Report

Cureus (2022)

Luísa Frutuoso Ana Marta Pereira Vera Oliveira Gil Gonçalves Mário Nora

Abdominal actinomycosis is a rare disease caused by a Gram-positive bacillus (Actinomyces). Liver manifestation is rare and, in patients with a history of cancer, differential diagnosis with secondary malignant disease can be difficult. Microbiological result is necessary for a correct diagnosis, though not always possible in preoperative workout. The authors present a case of hepatic actinomycosis that mimicked oncological disease and led to a more aggressive surgical approach.

Actinomycosis

Rare disease

10.7759/cureus.21234

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Citations (1)

Single and dual anastomosis duodenal switch for obesity treatment: a single-center experience

Surgery for Obesity and Related Diseases (2020)

Ana Marta Pereira Marta Guimarães Sofia S. Pereira Rui Ferreira de Almeida Mariana P. Monteiro

Biliopancreatic Diversion

Duodenal switch

Sleeve gastrectomy

Single Center

10.1016/j.soard.2020.09.029

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Citations (36)