Sandeep Batra

Indiana University Melvin and Bren Simon Comprehensive Cancer Center

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Sandra K. Althouse

Indiana University School of Medicine

Ashok Vaid

Medanta The Medicity

Mahvish Q. Rahim

Indiana University School of Medicine

Sandra Jones

Indiana University School of Medicine

Harit Chaturvedi

Max Healthcare

Roshni B. Patel

Alabama College of Osteopathic Medicine

Antonella Sassano

National Institutes of Health

Eleanor N. Fish

University Health Network

Ji Zhang

Indiana University School of Medicine

Beata Majchrzak

Adam Mickiewicz University in Poznań

Cooperative Institutions

Indiana University School of Medicine

Indiana University – Purdue University Indianapolis

Indiana University

Indiana University Health

University of Indianapolis

Max Super Speciality Hospital

Riley Hospital for Children

Indiana University Indianapolis

University School

Rajiv Gandhi Cancer Institute and Research Centre

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Placenta growth factor activates monocytes and correlates with sickle cell disease severity

Blood (2003)

Natalya Perelman Suresh Selvaraj Sandeep Batra Lori Luck Anat Erdreich‐Epstein

Monocyte

Proinflammatory cytokine

Leukocytosis

Hematopoietic growth factor

10.1182/blood-2002-11-3422

Cite

Citations (163)

Lungs on fire

BMJ Case Reports (2013)

Sandeep Batra Ashok Vaid Rahul Bhargava Sachin Gupta

A 50-year-old man was diagnosed as classical Hodgkin's lymphoma stage III B. He had been a reformed smoker and has had a coronary artery disease as his comorbidity. He was started on adriamycin, bleomycin, vinblastine, dacarbazine (ABVD)-based chemotherapy. An interim disease evaluation was suggestive of metabolic complete response after four cycles of ABVD. After completion of his sixth cycle, he presented with low-grade fever, dry cough, generalised malaise and increasing dyspnoea on exertion. FDG (18 fluoro-deoxyglucose) positron emission tomography (PET)-CT revealed intensely FDG avid diffuse activity in mid and lower zone both lung fields. He was started on intravenous steroids along with broad spectrum antibiotic and antifungal cover. Clinical, radiological and laboratory assays did not reveal any infective pathology. He was diagnosed as bleomycin-induced pulmonary toxicity (BIP). Despite best supportive care, his pulmonary functions deteriorated and he developed cardiac arrhythmias. He finally succumbed to the irreversible chemotherapy toxicity of a curable malignancy.

ABVD

Dacarbazine

Pulmonary toxicity

10.1136/bcr-2013-010388

Cite

Citations (4)

Systems Biology Approach Identifies Prognostic Signatures of Poor Overall Survival and Guides the Prioritization of Novel BET-CHK1 Combination Therapy for Osteosarcoma

Cancers (2020)

Pankita H. Pandya Lijun Cheng M. Reza Saadatzadeh Khadijeh Bijangi‐Vishehsaraei Shan Tang

Osteosarcoma (OS) patients exhibit poor overall survival, partly due to copy number variations (CNVs) resulting in dysregulated gene expression and therapeutic resistance. To identify actionable prognostic signatures of poor overall survival, we employed a systems biology approach using public databases to integrate CNVs, gene expression, and survival outcomes in pediatric, adolescent, and young adult OS patients. Chromosome 8 was a hotspot for poor prognostic signatures. The MYC-RAD21 copy number gain (8q24) correlated with increased gene expression and poor overall survival in 90% of the patients (n = 85). MYC and RAD21 play a role in replication-stress, which is a therapeutically actionable network. We prioritized replication-stress regulators, bromodomain and extra-terminal proteins (BETs), and CHK1, in order to test the hypothesis that the inhibition of BET + CHK1 in MYC-RAD21+ pediatric OS models would be efficacious and safe. We demonstrate that MYC-RAD21+ pediatric OS cell lines were sensitive to the inhibition of BET (BETi) and CHK1 (CHK1i) at clinically achievable concentrations. While the potentiation of CHK1i-mediated effects by BETi was BET-BRD4-dependent, MYC expression was BET-BRD4-independent. In MYC-RAD21+ pediatric OS xenografts, BETi + CHK1i significantly decreased tumor growth, increased survival, and was well tolerated. Therefore, targeting replication stress is a promising strategy to pursue as a therapeutic option for this devastating disease.

BRD4

Prioritization

Synthetic Lethality

10.3390/cancers12092426

Cite

Citations (13)

HOMOCYSTINURIA: AN UNUSUAL CAUSE OF CHRONIC RELAPSING PANCREATITIS

Journal of Pediatric Gastroenterology and Nutrition (1997)

Mark Lowenheim Sandeep Batra

Chronic relapsing pancreatitis in childhood is a rare entity. Etiologies usually considered include hereditary pancreatitis, hyperlipidemia, cystic fibrosis, hypercalcemia, congenital anomalies of the pancreatic duct as well as idiopathic chronic pancreatitis. An unusual and uncommon cause is homocystinuria. We report a 14 year old girl with a 5 year history of recurrent pancreatitis who was subsequently diagnosed to have homocystinuria based on clinical and lab parameters. She presented at 9 years of age with acute pancreatitis, her serum Amylase was 648 and Lipase was >1400. An ultrasound of her pancreas revealed fullness in the tail. Family history was nonrevealing. She responded to being placed NPO with normalization of her pancreatic enzymes. She was well until the age of twelve when she required a second admission for pancreatitis. She once again responded to being placed NPO. An ERCP revealed a dilated pancreatic duct consistent with chronic changes. Over the next two years she had numerous admissions for management of her pancreatitis. She responded to being placed NPO. She was well during the interim and performed well in school. She was subsequently evaluated by an ophthalmologist and diagnosed with dislocated lenses which initiated a workup for homocystinuria. Lab values obtained during an acute exacerbation revealed a plasma homocysteine level of 239.1 nmol/ml, plasma methionine of 286 mcmol/l and urine homocystine was 1822.7 mcmol/g. She has been treated with pyridoxine, folic acid, and a modified protein diet with normalization of her laboratory values, and with no recurrences of her symptoms. The cause of recurrent pancreatitis in homocystinuria is presumably related to endothelial damage and increased coagulability leading to occlusive vascular disease. Homocystinuria needs to be considered in the differential diagnoses of acute and chronic pancreatitis.

Homocystinuria

Pancreatic Disease

10.1097/00005176-199710000-00079

Cite

Citations (2)

Malignancy knows no boundaries

BMJ Case Reports (2013)

Sandeep Batra Ashok Vaid Rahul Bhargava Amanjeet Singh

A 47-year-old woman presented with ascites. There was history of large volume paracentesis and the drained ascitic fluid was found to be positive for malignant cells. Clinical examination revealed a soft tissue nodule over the skin of right iliac fossa and a small umbilical nodule besides presence of ascites. In addition, the patient had a breast lump of 2×2 cm in upper quadrant of right breast. Biopsy from the abdominal wall nodule revealed a malignant tumour with dense desmoplastic response. The tumour cells were pancytokeratin, CA125, WT1 positive and CDX2, CD10, villin, calretinin negative; thus immunohistochemically suggesting a primary tumor arising from ovary. Biopsy from breast lump showed malignant epithelial cells present in sheets with stromal dysplasia. Immunohistochemically tumour cells were positive for CK7. CA125, WT1, thus favouring a metastatic carcinoma to breast with possible primary arising from ovary.

Nodule (geology)

Quadrant (abdomen)

Metastatic Urothelial Carcinoma

10.1136/bcr-2013-010383

Cite

Citations (3)

Estimating the Risk of Chemotherapy Toxicity in Indian Geriatric Patient Population and Utility of Chemotherapy Risk Assessment Scale for High Age Patients (CRASH) Score

South Asian Journal of Cancer (2021)

Aditi Mittal Ranga Rao Rangaraju Amit Agarwal D Chandragouda Sandeep Batra

Background Aging is a heterogeneous process, and elderly population is diverse in health status and functional reserve. The present study was undertaken to predict severe chemotherapy toxicity using the Chemotherapy Risk Assessment Scale for High-Age Patients' (CRASH) score. Materials and Methods Elderly patients (age ≥65 years) with malignancy, who were planned to be treated with a new course of cytotoxic chemotherapy, were enrolled. The CRASH score was calculated, and patients were stratified into four categories, that is, low (0-3), intermediate (Int)-low (4-6), Int-high (7-9), and high (<9). Patients developing grade 3/4/5 nonhematologic (NH) or grade 4/5 hematologic (H) toxicity were taken as the development of severe toxicity. Results Of 100 enrolled patients, 64 (64%) were able to complete their prescribed treatment. Forty-four percent of patients (44 patients) of our study cohort experienced grade-4 H or grade 3/4 NH toxicity. The highest score in each category (heme/nonheme/CRASH) predicts nearly 100% toxicity risk. At a critical value of CRASH ≥ 6.5, the sensitivity is calculated as 100%, while specificity is 89.09%. The accuracy of prediction is 93.88%. The median time taken to develop toxicity was 39.5 days. Conclusion CRASH score utilizes clinical assessment and basic laboratory values. Yet, it accurately predicts severe chemotherapy toxicity above a critical value of 6.5. Based on the above study, the first 30 days are crucial as 45% of patients experienced toxicity in this time frame. With the help of these clinical predictive markers, the care of elderly will be optimized.

10.1055/s-0041-1729447

Cite

Citations (5)

Pediatric Mixed-Phenotype Acute Leukemia: What’s New?

Cancers (2021)

Sandeep Batra Anthony J Ross

Mixed-phenotype acute leukemias (MPAL) are rare in children and often lack consensus on optimal management. This review examines the current controversies and emerging paradigms in the management of pediatric MPAL. We examine risk stratification, outcomes of recent retrospective and prospective collaborative trials, and the role of transplantation and precision genomics, and outline emerging targets and concepts in this rare entity.

Risk Stratification

10.3390/cancers13184658

Cite

Citations (17)

Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation

Case Reports in Oncological Medicine (2016)

Sandeep Batra Stephen C. Martin Mehdi Nassiri Amna Qureshi Troy A. Markel

Histiocytic sarcoma (HS) rarely involves extranodal sites, such as the spleen. We report a unique pediatric case of massive splenomegaly and refractory Coombs negative hemolytic anemia (CNHA) secondary to HS. The CNHA resolved completely after an emergent splenectomy. Next generation sequencing (NGS) revealed novel ASXL1, PTPN11, KIT, and TP53 mutations, unmasking a clonal heterogeneity within the same neoplasm.

Histiocytic sarcoma

10.1155/2016/3179147

Cite

Citations (7)

Venous Thromboembolic Events in Adolescent and Young Adult Patients with Acute Lymphoblastic Leukemia

Journal of Adolescent and Young Adult Oncology (2022)

Sandra Jones Roshni B. Patel Mahvish Q. Rahim Sandra K. Althouse Sandeep Batra

Acute venous thromboembolisms (VTEs) are serious complications that occur during acute lymphoblastic leukemia (ALL) chemotherapy. The data elucidating risk factors for developing VTEs are limited in adolescent and young adult patients being treated per pediatric ALL protocols. In a cohort of 66 patients, 14 (21%) experienced VTEs. The majority of VTEs occurred during induction chemotherapy after the first dose of asparaginase, and in the upper extremities. Five-year relapse-free and overall survival were not impacted by VTEs. Contrary to VTEs in adults, hypoalbuminemia and increased body mass index were not associated with an elevated risk of VTE.

Hypoalbuminemia

Asparaginase

Induction chemotherapy

Acute lymphocytic leukemia

10.1089/jayao.2021.0136

Cite

Citations (2)

50 Years Ago in T J P

The Journal of Pediatrics (2021)

Michael J. Ferguson Sandeep Batra

Total body irradiation

Freedman

Minimal Residual Disease

10.1016/j.jpeds.2020.10.051

Cite

Citations (0)