Shigeyuki Saitoh

Sapporo Medical University

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Hirofumi Ohnishi

Sapporo Medical University

Kazuaki Shimamoto

Sapporo Medical University

Hirotsugu Ueshima

Shiga University of Medical Science

Hiroshi Akasaka

Osaka University

Katsuyuki Miura

Shiga University of Medical Science

Akira Okayama

Okayama Prefecture

Tetsuji Miura

Sapporo Medical University

Kiyomi Sakata

Iwate Medical University

Tomonori Okamura

Keio University

Hideaki Nakagawa

Kanazawa Medical University

Cooperative Institutions

Sapporo Medical University

149

Osaka University

The University of Tokyo

Shiga University of Medical Science

University of Oxford

Medical Research Council

Kyoto University

Keio University

British Heart Foundation

National Cerebral and Cardiovascular Center

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Dietary intake and urinary excretion of selenium in the Japanese adult population: the INTERMAP Study Japan

European Journal of Clinical Nutrition (2007)

Satoko Yoneyama Katsuyuki Miura Kazuyoshi Itai Katsushi Yoshita H Nakagawa

10.1038/sj.ejcn.1602842

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Citations (35)

Serum FABP4 concentration is independently associated with atherosclerosis in a general population without medication.

日本動脈硬化学会総会・学術集会プログラム・抄録集(Web) (2017)

Masato Furuhashi Satoshi Yuda Atsuko Muranaka Mina Kawamukai Megumi Matsumoto

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日本人における3種類の低炭水化物食と心臓代謝危険因子との関係:INTERMAP/INTERLIPID研究

European Journal of Nutrition (2016)

Nakamura Yasuyuki Hirotsugu Ueshima Okuda Nagako Katsuyuki Miura Kita Yoshikuni

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The Relationship of Dietary Cholesterol with Serum Low-Density Lipoprotein Cholesterol and Confounding by Reverse Causality: The INTERLIPID Study

Journal of Atherosclerosis and Thrombosis (2018)

Yukiko Okami Hirotsugu Ueshima Yasuyuki Nakamura Nagako Okuda Hideaki Nakagawa

The positive relationship between dietary cholesterol and serum cholesterol has been questioned by a set of recent cohort studies. This study aimed to investigate how employment status and education years relate to the association between dietary cholesterol and serum low-density lipoprotein cholesterol (LDL-C) in a Japanese population.A population-based, random sample, cross-sectional study (INTERLIPID) was performed. Among 1,145 Japanese individuals aged 40-59 years, 106 were excluded because of special diets, use of lipid-lowering drugs, hormone replacement, and missing data, leaving 1,039 individuals (533 men and 506 women). Dietary cholesterol was assessed from four 24-h dietary recalls, and LDL-C was measured enzymatically with an auto-analyzer. A standard questionnaire inquired about employment status and education years.In men, a 1 standard deviation (SD) higher dietary cholesterol was associated with 3.16 mg/dL lower serum LDL-C (P=0.009; unadjusted model). After adjustment for covariates, higher serum LDL-C was estimated per 1 SD higher intake of dietary cholesterol in nonemployed men [self-employed, homemakers, farmers, fishermen, and retired employees; β=＋9.08, 95% confidence interval (CI)=＋0.90-＋17.27] and less educated men (β=＋4.46, 95% CI=－0.97-＋9.90), whereas an inverse association was observed in employed men (β=－3.02, 95% CI=－5.49-－0.54) and more educated men (β=－3.66, 95% CI=－6.25-－1.07).In men who were nonemployed and less educated, a higher intake of dietary cholesterol was associated with elevated concentrations of serum LDL-C, whereas an inverse association was observed in men who were employed and more educated.

Causality

Reverse cholesterol transport

10.5551/jat.43075

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Citations (9)

Prognosis Predictor of Chronic-stage Acute Myocardial Infarction.

Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics (1999)

Hiroki Takahashi Shigeyuki Saitoh Shunsuke Takagi Kenji Shimamoto

北海道帯広市において1990年10月1日から1996年3月31日までの5年6カ月間に悉皆性を考慮した循環器疾患発症登録を施行した. 急性期死亡例を除く慢性期生存例194名を対象にアンケート法により予後追跡調査を行い, 急性心筋梗塞の慢性期生命予後規定因子について検討した. 追跡率は94.5%で平均追跡期間は1.62年である. 発症時病歴で女性が男性に比べ発症年齢が約10歳高く, 高血圧罹患者の割合が多い. 喫煙歴や飲酒歴保有者の割合は男性で多い. Kaplan-Meier 分析による慢性期生命予後規定因子は高齢者, 飲酒歴非保有者, 心筋梗塞や脳梗塞既往者, 腎機能障害者, Killip III度以上の心不全重症者, 急性期リハビリ未施行者, PTCA未施行者であった. Cox hazard model により全死亡に対するリスクを検討すると単変量解析では年齢が10歳増すごとに1.5倍に死亡リスクの増加, 65歳以上で2.6倍に死亡リスクの増加, 心筋梗塞や脳梗塞既往者で約2.5倍, 腎機能障害者で約4.6倍の死亡リスクの増加, また Killip III度以上の心不全重症者で約5.7倍の死亡リスクの増加を認めた. 一方, 飲酒歴保有者で0.3倍の死亡リスクの低下, PTCA施行者で約0.1倍の死亡リスクの低下, 急性期リハビリ施行者で約0.3倍の死亡リスクの低下を認めた. これらの因子を加えた多変量解析では, 全死亡に対する予後不良因子は飲酒歴非保有者とリハビリ未施行が採択された.本研究より日本人の急性心筋梗塞の慢性期予後規定因子として年齢, 飲酒歴, 心筋梗塞・脳梗塞既往歴, 腎機能障害, 心不全, 急性期リハビリ施行, PTCA施行が確認された. また病歴, 重症度を考慮しても急性期リハビリの施行が慢性期生命予後規定因子として採択され, 心筋梗塞後の早期離床はADL, QOLの保持や慢性期生命予後を考える上で重要であると示唆された.

Killip class

10.3143/geriatrics.36.721

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Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index ― The INTERLIPID Study ―

Circulation Journal (2018)

Maryam Zaid Katsuyuki Miura Akira Okayama Hideaki Nakagawa Kiyomi Sakata

Recently, high-density lipoprotein particles (HDL-P) have been found to be more strongly inversely associated with coronary artery disease (CAD) risk than their counterpart, HDL cholesterol (HDL-C). Given that lifestyle is among the first targets in CAD prevention, we compared the associations of HDL-P and HDL-C with selected lifestyle factors. Methods and Results: We examined 789 Japanese participants of the INTERLIPID Study: men (n=386) and women (n=403) aged 40-59 years in 1996-1998. Participants treated for dyslipidemias were excluded. Lifestyle factors included alcohol intake, smoking amount, and body mass index (BMI). Multivariable linear regression was used for cross-sectional analyses of these factors with HDL-P, HDL-C, HDL-P size subclasses (small, medium and large) and mean HDL-P size. In men, higher alcohol intake was associated with higher HDL-P and higher HDL-C. The associations of alcohol, however, were strongest with HDL-P. A higher smoking amount tended to be associated with lower HDL-P and HDL-C. In contrast, BMI was not associated with HDL-P, but was strongly inversely associated with HDL-C. While alcohol intake favored larger mean HDL-P size, smoking and BMI favored a lipid profile with smaller HDL-P subclasses and overall smaller mean HDL-P size. Similar, but generally weaker results were observed in women.Although both HDL-P and HDL-C are parameters of HDL, they have different associations with alcohol, smoking and BMI.

High-density lipoprotein

Alcohol intake

10.1253/circj.cj-18-0341

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Citations (26)

CORRELATIONS OF ADIPONECTIN WITH INSULIN RESISTANCE, LIPID METABOLISM AND ATHEROSCLEROSIS IN GENERAL MALE POPULATIONS

Journal of Hypertension (2004)

H Higashiura N Ura Junichi Ohata Hirofumi Ohnishi Satoru Takagi

Higashiura, H; Ura, N; Ohata, J; Ohnishi, H; Takagi, S; Saitoh, S; Takagawa, Y; Shimamoto, K Author Information

10.1097/00004872-200402001-00193

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Neuromuscular electrical stimulation increases serum brain-derived neurotrophic factor in humans

Experimental Brain Research (2018)

T. Kimura Fuminari Kaneko Erika Iwamoto Shigeyuki Saitoh Takashi Yamada

Turnover

10.1007/s00221-018-5396-y

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Citations (27)

Associations of metabolic factors, especially serum retinol-binding protein 4 (RBP4), with blood pressure in Japanese -the Tanno and Sobetsu study-

Endocrine Journal (2010)

Mizue Chiba Shigeyuki Saitoh Hirofumi Ohnishi Hiroshi Akasaka Kaneto Mitsumata

Excess secretion of various adipocyte-derived molecules has been linked with insulin resistance, obesity, diabetes, inflammation, atherosclerosis, and cardiovascular disease. Retinol-binding protein 4 (RBP4), one of the new adipocytokine, is recently reported to provide a link between insulin resistance and features of metabolic factors. Hypertension is one of the most influential risk factors among cardiovascular disease. We examined the relationship between systolic blood pressure (BP) levels and metabolic factors including homeostasis model assessment of insulin resistance (HOMA-R), high sensitivity c-reactive protein (hs-CRP), adiponectin, and RBP4. The subjects were 153 men aged 59±14 years and 224 women aged 57±14 years who had undergone medical check-ups in rural communities in 2007. Systolic BP was positively correlated with HOMA-R, hs-CRP and RBP4 but not with adiponectin in women. There was a positive significant relationship between serum RBP4 levels and blood pressure in women, but such a relationship was not found in men. Serum RBP4 levels were not correlated with HOMA-R in either men or women. Serum RBP4 levels negatively were correlated with estimated glomerular filtration rate (eGFR) in women but not in men. Multiple regression analysis revealed that serum RBP4 levels significantly were related to systolic BP independently of age, sex, body mass index (BMI), total cholesterol levels and eGFR. Our study showed that increased levels of RBP4 as well as HOMA-R and hs-CRP in women were significantly associated with increased levels of systolic BP.

Dyslipidemia

10.1507/endocrj.k10e-054

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Relationship of metabolic syndrome and insulin resistance with microalbuminuria in senior citizens of rural communities in Japan -The Tanno and Sobetsu Study-

Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics (2008)

Tetsuya Tabeya Hirofumi Ohnishi Shigeyuki Saitoh Hiroshi Akasaka Kaneto Mitsumata

We investigated the relationship of metabolic syndrome (MetS) and insulin resistance (IR) with microalbuminuria in senior citizens of rural communities in Japan.The subjects were 338 senior citizens (age 65 or older) who underwent medical examinations in the towns of Tanno and Sobetsu, Hokkaido in 2005. The following participants were excluded: those with missing data, those with type 2 diabetes (fasting plasma glucose >or=126 mg/dl and/or those who were on medication for diabetes), those who were on medication for hypertension and those with macroalbuminuria (urinary albumin creatinine ratio (ACR) >or=300 mg/g.Cr). The subjects were divided into two groups according to the Japanese criteria of MetS: a MetS group and a non-MetS group. The percentages of subjects with microalbuminuria (ACR >or=30 mg/g.Cr) in the two groups were compared. We also investigated the relationship between IR and microalbuminuria using homeostasis model assessment (HOMA-R).The percentage of subjects with microalbuminuria was significantly higher in the MetS group than in the non-MetS group. Multiple logistic regression analysis showed that there was a significant relationship between MetS and microalbuminuria (relative risk: 3.09, 95%CI: 1.18-8.07) and that there was also a significant relationship between HOMA-R and microalbuminuria (relative risk: 1.91, 95%CI: 1.14-3.20).It may be important for prevention of microalbuminuria in patients with MetS not only to manage blood pressure and blood glucose but also to manage IR, which is part of the background of accumulation of these risk factors.

Microalbuminuria

10.3143/geriatrics.45.302

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Citations (1)