To study the relationship between non-alcoholic fatty liver disease and insulin resistance.63 non-alcoholic fatty liver disease patients(male 35,femal 28) and 20 obesity without fatty liver disease were selected.Fasting serum insulin levels was measured by radio-immunoassay,insulin resistance index was estimated by the homeostasis model assessment(HOMA-IR).Compared to controlgroup,patients with non-alcoholic fatty liver disease were characterized by hyperinsluinemia,elevated insulin resistance index(P0.01).Serum insulin and insulin resistance index were higher in heavy fatty liver disease patients than medium and light patients(P0.05).In the pathogeneses of non-alcoholic fatty liver disease,insulin resistance was an original factor probably and not a following changing.
ObjectiveTo analyze the risk factors of YMDD mutation in patients with chronic hepatitis B during lamivudine therapy.MethodThe clinical data and serum of 279 chronic hepatitis B treated with lamivudine were collected.YMDD mutation were determined and analyzed.ResultsPatients with ALT5 ULN,HBV-DNA≥107copies/ml and complication with liver cirrhosis of abnormal liver function at baseline had significantly higher YMDD mutation rate.There was no association between YMDD mutation rate and HBeAg status.Chronic hepatitis B patients who gained early virological response had significantly higher YMDD mutation rate than patients who did not gain early virological response.ConclusionHigher HBV-DNA loading and complication with liver cirrhosis of abnormal liver function at baseline and no early virological response seem to be the major determinants for the YMDD mutation during lamivudine therapy.
