R Rullo

Agostino Gemelli University Polyclinic

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V. Festa

Ospedale San Filippo Neri

F Palomba

University of Cagliari

F Gombos

University of Naples Federico II

Felice Femiano

University of Campania "Luigi Vanvitelli"

Francesco Carinci

University of Ferrara

Letizia Perillo

University of Campania "Luigi Vanvitelli"

Francesco Addabbo

University of Bari Aldo Moro

G Laino

University of Salerno

Alessandro Lanza

University of Campania "Luigi Vanvitelli"

Luigi Guida

University of Campania "Luigi Vanvitelli"

Cooperative Institutions

University of Naples Federico II

103

University of Campania "Luigi Vanvitelli"

University of Foggia

University of Bologna

Istituti di Ricovero e Cura a Carattere Scientifico

University of Messina

Federico II University Hospital

University of Ferrara

University of Milan

Istituto Nazionale di Fisica Nucleare, Sezione di Napoli

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Human dental pulp stem cells: from biology to clinical applications

Journal of Experimental Zoology Part B Molecular and Developmental Evolution (2008)

Riccardo d’Aquino Alfredo De Rosa Gregorio Laino Filippo Caruso Luigi Guida

Dental pulp stem cells (DPSCs) can be found within the "cell rich zone" of dental pulp. Their embryonic origin, from neural crests, explains their multipotency. Up to now, two groups have studied these cells extensively, albeit with different results. One group claims that these cells produce a "dentin-like tissue", whereas the other research group has demonstrated that these cells are capable of producing bone, both in vitro and in vivo. In addition, it has been reported that these cells can be easily cryopreserved and stored for long periods of time and still retain their multipotency and bone-producing capacity. Moreover, recent attention has been focused on tissue engineering and on the properties of these cells: several scaffolds have been used to promote 3-D tissue formation and studies have demonstrated that DPSCs show good adherence and bone tissue formation on microconcavity surface textures. In addition, adult bone tissue with good vascularization has been obtained in grafts. These results enforce the notion that DPSCs can be used successfully for tissue engineering.

Bone tissue

10.1002/jez.b.21263

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Citations (147)

[An unusual case of a sialocele secondary to a traumatic lesion of Stensen's duct].

PubMed (1983)

F Gombos G Laino R Rullo

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Citations (2)

Preauricular and laterocervical swelling caused by a mandibular follicular cyst.

PubMed (2013)

R Rullo Francesco Addabbo V. Festa

Follicular Cyst

Mandibular Diseases

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[Lupus erythematosus. 2. Systemic Lupus erythematosus: antibody symptomatology, other laboratory evidence, diagnosis, course and prognosis; discoid Lupus erythematosus; drug induced Lupus].

PubMed (1989)

M Frojo A Lamparelli F Palomba R Rullo

The AA. in this note II report the most recent acquisitions about the clinical features, hematology and serology of Systemic Lupus Erythematosus. Moreover describe the main characteristics of Discoid Lupus Erythematosus and of Lupus due to drugs.

Discoid lupus erythematosus

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Acetylsalicylic Acid Inhibits Proliferation of Human Bone Marrow Stromal Cells and Matrix Mineralization

International Journal of Immunopathology and Pharmacology (2008)

Luigi Guida Marco Annunziata Irene Passaro C Buonaiuto R Rullo

Acetylsalicylic acid (ASA) and other non-steroidal anti-inflammatory drugs have been shown to potentially inhibit bone healing and bone formation in both animal and clinical studies. Due to the extensive diffusion of ASA-based long-term therapies, the implications of such a side-effect are of interest in all types of bone surgery, including bone grafting procedures and dental implant placement. In this study, we investigate the effect of ASA at therapeutic concentrations on the proliferation and osteogenic differentiation of human bone marrow stromal cells (BMSCs). Primary cultures of BMSCs were isolated and expanded. Their proliferation in response to ASA 50, 100 and 200 microg/ml was evaluated by MTT assay and 3H-thymidine incorporation. Cell cycle machinery was also investigated by FACS and analysis of inhibitors of cyclin-dependent kinases (CDKIs). ASA inhibited BMSC proliferation and DNA synthesis in a dose-dependent manner down to 60% of control (ASA 200 mcg/ml) at 72 h. Cell cycle analysis showed a decrease of BMSCs in the S and G2/M phases with a concomitant accumulation in G0/1 in ASA treated cells. The finding was associated to increased levels of some CDKIs, namely p27(Kip1) and p21(Cip1), whereas ASA did not affected p16(Ink4A) level at any of the concentrations employed. The matrix mineralization, that represents the major feature of the osteogenic commitment, was assessed by a specific staining procedure (von Kossa) and by calcium content determination. Both the methods demonstrated an extensive reduction (greater than 90 percent) of extracellular calcification at 200 microg/ml ASA. On the basis of our results, we can hypothesize that the widely reported inhibition of bone healing by ASA might be sustained both by a direct anti-proliferative effect on BMSCs and by an alteration of the extracellular calcification.

Von Kossa stain

MTT assay

10.1177/039463200802100416

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Citations (8)

Speech assessment in cleft palate patients: A descriptive study

International Journal of Pediatric Otorhinolaryngology (2009)

R Rullo D. Di Maggio V. Festa Nicoletta Mazzarella

Nasality

Rank correlation

Intelligibility (philosophy)

Palatoplasty

10.1016/j.ijporl.2008.12.011

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Citations (38)

TGF Alpha Has Low Protein Expression in Nonsyndromic Clefts

Journal of Craniofacial Surgery (2007)

R Rullo F Gombos Franca Ferraraccio Antonio Farina Danila Morano

Genetic studies have demonstrated that nonsyndromic cleft is composed of two separate entities: the cleft palate only and cleft of the lip, alveolus with or without cleft palate; both have a heterogeneous genetic background and environmental factors contribute to the onset of these malformations. The role of transforming growth factor alpha (TGF-A) was considered possible, but conflicting results have been reported. To detect if TGF-A is involved in the onset of cleft diseases, a series of patients with nonsyndromic clefts and control subjects were analyzed with regard to protein expression. Forty-three patients with nonsyndromic clefts and 21 unaffected subjects were enrolled in this study. Paraffin-embedded specimens were matched with TGF-A antibody and then scanned with a computerized image analyzer. TGF-A was scored as absent, moderately (from 10% to 30%), and highly expressed in epithelium, gland, and muscle. Data were statistically analyzed with a Kruskal-Wallis test. Comparison between control subjects and patients with clefts showed that only gland and epithelium reached a significant P value. A subsequent comparison between cleft of the lip, alveolus with or without cleft palate and cleft palate only groups demonstrated a statistically significant difference only for gland. TGF-A was decreasingly expressed in unaffected, cleft of the lip, alveolus with or without cleft palate, and patient with cleft palate only and thus further strength has been given to its role in the onset of the disease.

Alpha (finance)

10.1097/scs.0b013e3180de6506

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Citations (5)

Evaluation of upper arch changes in patients with unilateral cleft lip and palate after maxillary expansion using digital dental casts

STOMATOLOGY EDU JOURNAL (2020)

Fabrizia d’Apuzzo Ludovica Nucci Abdolreza Jamilian R Rullo Vincenzo Grassia

Objective To compare the upper arch dimensions of young patients with unilateral cleft lip and palate (UCLP) before and after treatment with bonded maxillary expander and hybrid activation protocol using digital dental casts. Methods Sixteen subjects with UCLP, aged between 7 and 14 years (mean age 10.9 ± 2.7 years) consecutively treated with bonded maxillary expander and hybrid activation were included. The dental casts before and after treatment were digitalized using a 3Shape scanner. Intercanine, interpremolar and intermolar widths (at cusp and gingival levels) and arch perimeters were measured. The significance level for statistical analyses was set as p < 0.05. Results The total treatment time using the hybrid expansion protocol lasted 12 ± 1.9 months while the active expansion time lasted 4 ± 0.2 months. Patients with UCLP showed significant differences in all transverse upper arch dimensions both at cusp and gingival level. Conclusion The use of a bonded maxillary expander with a hybrid activation protocol during growth may be efficient to improve all transverse upper arch widths in patients affected by UCLP

Dental arch

Hard palate

10.25241/stomaeduj.2020.7(3).art.4

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Citations (1)

The Use of Piezosurgery in Genioplasty

Journal of Craniofacial Surgery (2016)

R Rullo V. Festa Francesco Rullo Oreste Trosino Vincenzo Cerone

The aim of this study was to compare the postoperative complications during genioplasty using piezosurgery devices or traditional rotating drills. Forty patients underwent genioplasty to solve their chin anomalies. This study showed that, using piezosurgery, pain and swelling were reduced compared to the traditional technique in the immediate postoperative period of healing (within 15 days). Paresthesia was observed in all patients up to 15th postoperative day, independently of the used surgical technique, but at the sixth postoperative month it was completely absent.

Genioplasty

10.1097/scs.0000000000002473

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Citations (33)

[Gingival hyperplasia associated with the therapeutic use of nifedipine: review of clinical cases].

PubMed (1989)

G Laino R Rullo R Serpico Menditto

The AA., starting point for some clinical cases occurred to their observation, deal with gingival hyperplasia by calcium-antagonists, showing that, not with standing the unlike aetiology, the clinical and histological picture is like the anticonvulsive or immunedepressor gingivitis.

Etiology

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