Yoshihisa Watanabe

Vitrogen (Brazil)

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Interactions of microcapsules with human polymorphonuclear leucocytes.

Chemical and Pharmaceutical Bulletin (1984)

Yoshihisa Watanabe Tamotsu Kondo Masaki Miyamoto Shigeru Sasakawa

Two types of microcapsules with different negative surface potentials, poly (1, 4-piperazinediylterephthaloyl) microcapsules containing various concentrations of sodium polystyrene sulfonate solution and hemolysate-loaded polyamide microcapsules of different degrees of carboxylation, were prepared by using an interfacial polymerization technique, and the interactions of these microcapsules with human polymorphonulcear leucocytes (PMNs) were investigated as a function of the surface potential of the microcapsules in the absence and presence of plasma proteins. The rate of oxygen consumption by PMNs was taken as a measure of the interaction. In the absence of plasma proteins, the rate of oxygen consumption by PMNs increased with increasing difference in surface potential between the microcapsules and PMNs. The presence of plasma proteins affected the rate of oxygen consumption, which was dependent on the protein species present and related to the surface potential of the microcapsules. This was interpreted as showing that the surface potential of the microcapsules exerts a great influence on the mode and amount of protein adsorption on the microcapsule surface.

Polystyrene

10.1248/cpb.32.2788

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Citations (13)

TWO CASES OF FAMILIAL IDIOPATHIC HYPOPARATHYROIDISM

Nihon Naika Gakkai Zasshi (1982)

Yukiko Ide Takao YOSHIWARA Masatoshi Watanabe Junichi Yokoyama Yoichi Sakamoto

特発性副甲状腺機能低下症の同胞発症例(兄と弟)について報告した.症例1 (兄): 27歳,大工.腰背部の筋肉痛と痙〓発作を主訴に2回の入院.第2回目入院時の血清Ca 2.5mEq/l, P 4.8mg/dl, Ellsworth-Howard試験陽性などより特発性副甲状腺機能低下症と診断した.症例2 (弟): 21歳,電気店勤務.痙〓発作を主訴に入院.兄と同様に血清Ca 2.9mEq/l, P 5.2mg/dl, Ellsworth-Howard試験陽性などより特発性副甲状線機能低下症と診断した.さらに皮膚のCafe-au-lait spotsを伴う広範な色素沈着,二分脊椎がありvon Recklinghausen病の合併と診断した. 2症例とも低Ca血症に伴う痙〓発作と大脳の基底核の石灰化像(CT-scanにて証明)がみられたが,外胚葉系の異常や白内障はなく,心電図の異常所見もなかつた.兄の例では,脳波の異常所見と血清CPKおよびLDHの高値がみられた. 2症例とも, Ca剤と1α-OH vitamin D3の投与により症状消失,検査成績の正常化がみられた.本疾患の病因はいまだ不明であるが,自己免疫異常の関与が考えられている.本症でも,父方の伯母に慢性甲状腺炎がみられた.一方,特発性副甲状腺機能低下症家族内発症例では,遺伝性疾患を合併するという報告が多く,本報告の弟の症例にvon Recklinghausen病の合併がみられた.さらに家族歴から,遺伝形式としては常染色体優性遺伝が疑われた.

Hypoparathyroidism

10.2169/naika.71.818

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Transpapillary biopsy of the gallbladder disease

Gastroenterology (1998)

Yoshihisa Watanabe Hirohiko Goto Yoshiki Hirooka Akihiro Ito S. Hayakawa

Gallbladder disease

10.1016/s0016-5085(98)82232-4

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Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study

British Journal of Oral and Maxillofacial Surgery (2016)

Yoshihisa Watanabe Hitoshi Higuchi Minako Ishii-Maruhama Yuka Honda Akiko Yabuki-Kawase

Midazolam

10.1016/j.bjoms.2016.02.006

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Citations (19)

Bovine conceptus of Bos indicus produced by somatic cell nuclear transfer and parthenogenesis present morphological variations since the blastocyst stage

Arquivo Brasileiro de Medicina Veterinária e Zootecnia (2015)

Franceliusa Delys de Oliveira Juliano Rodrigues Sangalli Flávio Vieira Meirelles Felipe Perecin P.P.C. Silva Filho

In cattle, embryo development is characterized by the appearance of two distinct cell layers, the trophectoderm and the inner cell mass. The latter will undergo differentiation to form the embryonic disc consisting of the epiblast and hypoblast. The aim of this study was to ultrastructurally characterize the bovine embryo from different in vitro production techniques, with emphasis on trophectoderm and inner cell mass cells. Bovine embryos on day 7 (conception = D1) of pregnancy, derived via in vitro production techniques, were fixed for light and transmission electron microscopy processing. Results suggested that embryos produced by nuclear transfer of somatic cells and parthenogenesis showed significant changes in macroscopic and microscopic structure. Size was reduced, and the inner cell mass had no defined shape. Furthermore, organelles responsible for the absorption processes, communication, growth, and cellular metabolism were fewer and had changes in shape, when compared to results in embryos produced by in vitrofertilization. We concluded that embryos produced by parthenogenesis and SCNT exhibit morphological differences when compared with IVF embryos, such as undeveloped blastocoel, poorly defined distribution of ICM, and morphological differences in organelles.

Inner cell mass

Epiblast

Blastocoel

Blastomere

Parthenogenesis

10.1590/1678-4162-7647

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Comparison of baking quality of bread flours milled from domestic and foreign wheats.

NIPPON SHOKUHIN KOGYO GAKKAISHI (1986)

Gisho Goshima Yoshihisa Watanabe Hotaka SHINGU Hirohiko ISOSAKI Haruhito Tsuge

内麦粉4種と外麦粉2種を用いて,製パン製に関する比較実験をした.(1) 内麦粉,外麦粉より澱粉を分別し,その性質を比較すると,一般成分に顕著な差はない.しかし,内麦澱粉は膨潤度,溶解度共に非常に高い.(2) AACC法による,内麦粉,外麦粉生地について発酵実験の結果,イーストを多くすればCO2の発生量は多くなるが,生地の膨張率は内麦粉においては120分位で最大を示し,その後は減少した.(3) 直捏法と生地発酵省略法で製パンし,比容積を比較した結果,生地発酵省略法が良好であった.またショートニングを多くすることにより,グルテン,澱粉,ショートニングの相互作用が改善されて,ガスの放出が防止されることが明らかとなった.しかし内層はきめが粗く,質的にはなお,外麦製パンに比べて劣りやや硬いパンとなる難点が認められる.

10.3136/nskkk1962.33.2_102

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Citations (2)

Abstracts of selected papers presented at the 78th general meeting of the Japanese Society of Gastroenterology

Gastroenterologia Japonica (1993)

Motoyasu Kusano Toshikazu Sekiguchi Nobuyoshi Hanyu Teruaki Aoki Yasuhiro Matsushima

Colorectal Surgery

Surgical oncology

10.1007/bf02776959

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Citations (0)

Comparative metabolism of sulfamidine and chlordimeform in rats

Journal of Agricultural and Food Chemistry (1987)

Yoshihisa Watanabe Fumio Matsumura

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparative metabolism of sulfamidine and chlordimeform in ratsYoshihisa Watanabe and Fumio MatsumuraCite this: J. Agric. Food Chem. 1987, 35, 3, 379–384Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/jf00075a024https://doi.org/10.1021/jf00075a024research-articleACS PublicationsRequest reuse permissionsArticle Views48Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

10.1021/jf00075a024

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Citations (1)

[Efficacy of oral midazolam as premedication in adult].

PubMed (1994)

K. Kikuchi Amane Konishi Yoshihisa Watanabe

Midazolam was administered as a premedicant to 90 patients aged from 20 to 55 years with ASA status 1 or 2. The patients were divided into 3 groups: group I 10 mg orally, group II 20 mg orally, group III 5 mg intramuscularly. All premedications were given 30 minutes before entering the operating room. The perioperative effects of midazolam on blood pressure, pulse rate, respiratory rate and SpO2 as well as sedative, hypnotic and amnemonic effects were evaluated in these patients. There were no remarkable changes in the blood pressure, pulse rate or respiratory rate. There was no problem on the upper airway tract, but a slight decrease in SpO2 was observed in a few patients. In this study, sedative and hypnotic effects were almost satisfactory. Midazolam produced significant anterograde amnesia, and the amnemonic rate was 66.7% in group I and 86.7% in group II and III. In conclusion, oral midazolam is an effective preanesthetic medication in adult.

Midazolam

Premedication

Respiratory Rate

Pulse rate

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Citations (4)

Produção in vitro de embriões após recuperação de oócitos guiada por ultra-som em fêmeas nelore

Anais (1998)

Mia Watanabe Raysildo Barbosa Lôbo P. H. Franceschini A Dayan R. A. Vila

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