Mirian Bonifácio

Universidade Federal de São Paulo

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Ana Cláudia Muniz Rennó

Universidade Federal de São Paulo

Cintia Cristina Santi Martignago

Universidade Federal de São Paulo

Lívia Assis

Universidade Federal de São Paulo

Júlia Risso Parisi

Universidade Metropolitana de Santos

Daniel Araki Ribeiro

Universidade Federal de São Paulo

Lais Caroline Souza-Silva

Universidade Federal de São Paulo

Homero Garcia-Motta

Universidade Federal de São Paulo

Matheus de Almeida Cruz

Universidade Federal de São Paulo

Isabella Liba Pandolfo

Universidade Federal de São Paulo

Ana Claudia Muniz Renno

Universidade Federal de São Paulo

Cooperative Institutions

Universidade Federal de São Paulo

Universidade Federal de São Carlos

Instituto de Saúde

Universidade de São Paulo

University of Geneva

HES-SO University of Applied Sciences and Arts Western Switzerland

Universidade Brasil

Fundação de Apoio à Universidade Federal de São Paulo

Universidade Estadual Paulista (Unesp)

Universidade Estadual de Campinas (UNICAMP)

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Effects of photobiomodulation on glucose homeostasis and morphometric parameters in pancreatic islets of diabetic mice

Lasers in Medical Science (2021)

Mirian Bonifácio Izabelle Dias Benfato Matheus de Almeida Cruz Daniele Correia de Sales Isabella Liba Pandolfo

Homeostasis

Pancreatic Islets

10.1007/s10103-021-03434-7

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Citations (15)

Mesenchymal Stem Cell-Enriched Hydrogels for the Treatment of Knee Joint Disorders: A Systematic Review

Regenerative Engineering and Translational Medicine (2024)

Mirian Bonifácio Homero Garcia-Motta Cintia Cristina Santi Martignago Lais Caroline Souza-Silva Júlia Risso Parisi

10.1007/s40883-024-00339-z

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A Review of Cartilage Defect Treatments Using Chitosan Hydrogels in Experimental Animal Models

Current Pharmaceutical Biotechnology (2023)

Lais Caroline Souza-Silva Cintia Cristina Santi Martignago Homero Garcia Motta Mirian Bonifácio Ingrid Regina Avanzi

Chitosan (CS) is a polycationic polysaccharide comprising glucosamine and N-acetylglucosamine and constitutes a potential material for use in cartilage tissue engineering. Moreover, CS hydrogels are able to promote the expression of cartilage matrix components and reduce inflammatory and catabolic mediator production by chondrocytes. Although all the positive outcomes, no review has analyzed the effects of CS hydrogels on cartilage repair in animal models.

10.2174/0113892010245946230919062908

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Laser acupuncture in musculoskeletal disorders: A systematic review of randomized clinical trials

Research Society and Development (2025)

Ana Beatriz Balão Patrícia Gabrielli Vassão Mirian Bonifácio Homero Garcia-Motta Beatriz Mendes Credidio

Musculoskeletal disorders (MSDs) are typically characterized by pain (often persistent) and limitations in mobility, decrease in the level of functioning and reduction in the quality of life and alternative therapeutical interventions have been studied to manage symptomatology such as laser in acupuncture points (LA). The aim of this study is to systematically review the literature of the use of LA in MSDs in pain and functional capacity. PubMed and EMBASE were systematically searched using the following terms: low-level laser therapy (LLLT) and acupuncture and ten randomized clinical trials (RCTs) that used LA in MSDs were selected. All the studies used the near-infrared PBMT irradiation, with an energy per point from 1J to 72J, power from 30 mW to 400 mW, number of sessions from 4 to 24 and application at acupuncture points according to each MSDs. Most studies have shown a significant decrease in pain and symptoms, and an increase of functionality, strength, and mobility after treatment with LA. This review demonstrates that LA produced positive effects in pain and functionality of patients with MSDs, although the evidence does not determine an effective dosage window for LA, the possible range of application adjusted and designed to fit specific musculoskeletal conditions.

10.33448/rsd-v14i2.48244

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Efficacy and safety of intense pulsed light in rosacea: A systematic review

Indian Journal of Dermatology Venereology and Leprology (2024)

Cintia Cristina Santi Martignago Mirian Bonifácio Laura Takahashi Ascimann Patrícia Gabrielli Vassão Júlia Risso Parisi

Background Rosacea is a chronic inflammatory disease of the skin characterised by facial erythema, oedema, telangiectasias, papules, pustules and nodules. There is a paucity of effective therapeutic modalities for the management of rosacea. Intense Pulsed Light (IPL), a modality in which flash lamps installed in an optical treatment device (head or tip) with mirrors to reflect light, has in recent times gained popularity in the management of this condition. Aim This systematic review aims to evaluate the efficacy, safety and adverse effects of IPL treatment for rosacea. Methods This systematic review was conducted in accordance with the Preferred Reporting Item for Systematic Reviews and Meta-Analysis. The electronic databases searched were Medline, PubMed and Scopus databases. The Risk of bias in non-randomised studies of interventions (ROBINS-I) and risk-of-bias tools for randomised trials (RoB-2) was employed to assess the risk of bias. Results Of a total of 233 articles retrieved from Medline, Scopus and PubMed databases, 14 studies qualified for final analysis. The studies included patients with Fitzpatrick skin types I to IV, with ages ranging from 15 to 78 years. Although the included studies showed heterogeneity between the parameters used, most studies demonstrated positive effects of IPL treatment on telangiectasia and erythema in rosacea and that the adverse effects presented were transitory. Limitation The methodological quality of the included studies was poor. Conclusion Although most studies showed the efficacy of IPL in the treatment of rosacea, the poor quality of the studies was of concern.

Intense pulsed light

Erythema

10.25259/ijdvl_1029_2022

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Hydrogels Loaded with Mesenchymal Stem Cells Extracellular Vesicles for Treating Knee Joint Disorders: A Systematic Review

Regenerative Engineering and Translational Medicine (2023)

Homero Garcia-Motta Mirian Bonifácio Cintia Cristina Santi Martignago Lais Caroline Souza-Silva Beatriz Soares‐Silva

Articular cartilage repair

Chondrogenesis

10.1007/s40883-023-00326-w

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Citations (1)

Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review

Marine Drugs (2025)

Cintia Cristina Santi Martignago Camila de Souza Barbosa Homero Garcia Motta Beatriz Soares‐Silva Erica Paloma Maso Lopes Peres

The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting Pseudomonas aeruginosa, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. The structural features of the active compounds selected in this review may provide a foundational framework for developing new, highly bioactive antimicrobial agents.

Sponge

10.3390/md23010043

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Photobiomodulation in diabetic rats: Effects on morphological, pancreatic parameters, and glucose homeostasis

Journal of Biophotonics (2023)

Isabella Liba Pandolfo Mirian Bonifácio Izabelle Dias Benfato Matheus de Almeida Cruz Marcia R. Nagaoka

Abstract Photobiomodulation (PBM) has therapeutic effects on wound healing, diabetic microangiopathy, and retinopathy. However, little is known about the use of PBM for the treatment of diabetes mellitus (DM). In this context, we aimed to evaluate the effects of PBM on pancreas morphology and insulin and glucose tolerance in an experimental model of DM. Thus, DM was induced by streptozotocin (STZ) (60 mg/kg). Subsequently, the rats were treated with PBM (808 nm and 30 J/cm 2 ). After euthanasia, morphometric parameters and immunoreactivity for insulin and 8‐OHdG were evaluated in the pancreas. The results showed that treated animals had higher values of body mass and higher values in the number of beta cells in the pancreas. In conclusion, PBM resulted in decreased weight loss in STZ‐induced diabetic rats and presented a stimulatory effect on the pancreas of the treated animals, highlighting the promising effects of this therapy in the clinical condition of DM.

Microangiopathy

Homeostasis

10.1002/jbio.202300182

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Citations (1)

Association of a Skin Dressing Made With the Organic Part of Marine Sponges and Photobiomodulation on the Wound Healing in an Animal Model

Marine Biotechnology (2024)

Abdias Fernando Simon Sales Karolyne dos Santos Jorge Sousa Amanda de Souza Mirian Bonifácio Tiago Akira Tashiro de Araújo

Immunostaining

Granulation tissue

Sponge

Rat model

10.1007/s10126-024-10295-y

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Citations (1)