Jean‐Marc Porcher

Stress Environnementaux et Biosurveillance des Milieux Aquatiques

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François Brion

Institut national de l'environnement industriel et des risques

Sélim Aı̈t-Aı̈ssa

Institut national de l'environnement industriel et des risques

Wilfried Sánchez

Ifremer

Anne Bado‐Nilles

Institut national de l'environnement industriel et des risques

Alain Geffard

Université de Reims Champagne-Ardenne

Olivier Palluel

Stress Environnementaux et Biosurveillance des Milieux Aquatiques

Nathalie Hinfray

Institut national de l'environnement industriel et des risques

Cyril Turiès

Stress Environnementaux et Biosurveillance des Milieux Aquatiques

Benjamin Piccini

Institut national de l'environnement industriel et des risques

Rémy Beaudouin

Stress Environnementaux et Biosurveillance des Milieux Aquatiques

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Centre National de la Recherche Scientifique

151

Institut national de l'environnement industriel et des risques

127

Stress Environnementaux et Biosurveillance des Milieux Aquatiques

Université de Reims Champagne-Ardenne

Inserm

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Université Claude Bernard Lyon 1

Université Le Havre Normandie

Université de Montpellier

Normandie Université

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Effect-directed analysis of endocrine-disrupting compounds in multi-contaminated sediment: identification of novel ligands of estrogen and pregnane X receptors

Analytical and Bioanalytical Chemistry (2013)

Nicolas Creusot Hélène Budzinski Patrick Balaguer Saïd Kinani Jean‐Marc Porcher

Pregnane X receptor

Pregnane

Solid phase extraction

Alkylphenol

10.1007/s00216-013-6708-5

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Citations (72)

Pulmonary responses to silica dust : the influence of crystalline structures and physico-chemical properties

Sylvie Honnons Dominique Oberson Agnès Wastiaux Stanisław Dźwigaj H. Pézerat

The inhalation of silica crystalline polymorphs leads to the development of pulmonary nodules that vary in extent and in fibrotic content. In this study, a single protocol was used to test different silica samples (i.e., 2 non-crystalline samples: one vitreous silica, one diatomaceous earth , 4 crystalline samples: one pure a-quartz ground in a wet atmosphere, one of the same quartz heated until it becomes oc-cristobalite and 2 cristobalites obtained by heating diatomaceous earth). Wistar rats received a single intra-tracheal injection of alveolar dust and were followed over a period of 3 months. The results were exploited using macroscopic examination (wet lung weight), histological examination and biochemical dosing (hydroxyproline, lipid, and silica content). The results showed that vitreous silica, diatomaceous earth, wet-ground quartz and both types of cristobalites are responsible to a greater or lesser extent for the pulmonary reaction typical of exposure to silica (i.e., nodules ); with different cellular and fibrotic surface areas for each sample. a-cristobalite (obtained from the wet-ground quartz heated to a very high temperature; 1,300 °C) leads to the formation of only small foreign-body granulomas. All crystalline minerals tested caused alveolar lipoproteinosis. It was thus concluded that the crystalline structure plays a less important role than the surface state in the formation of silicotic nodules.

Silicosis

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Evaluation of Tumor Necrosis Factor-α (TNF) as an Exposure or Risk Marker in Three French Coal Mining Regions

Experimental Lung Research (1994)

Jean‐Marc Porcher Dominique Oberson N. Viseux P Sébastien Sylvie Honnons

Several studies have shown the crucial role of the tumor necrosis factor-alpha (TNF) in the fibrosis induced by dusts containing silica and its role in the transition from simple pneumoconiosis (CWSP) to progressive massive fibrosis (PMF). To evaluate the nocivity of dust exposure among coal miners (n = 474) from different mining regions in France (e.g., Nord-Pas de Calais, Lorraine, and Provence), spontaneous and LPS or silica-induced TNF released by peripheral blood monocytes was quantified. The primary aim of this effort was to study the link between the prevalence of coal workers pneumoconiosis (CWP) and TNF release. TNF levels were significantly different between active miners from the three regions. However, after correction for age and region, TNF was found not to be related to dust exposure. Interestingly, a very low, homogeneous expression of TNF was observed in the group from Provence. These results are probably related to the absence of pneumoconiosis in this area. A positive relation between profusion and TNF release was found for all stimulants among retired miners with PMF. Although in retired miners TNF release was consistently higher, the design of the study does not allow this effect to be separated from that of age. Both silica and nonstimulated TNF release were found to increase with increasing radiological symptoms; the opposite was found for LPS-induced release.

10.3109/01902149409064399

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Development of an untarget metabolomics approach based on LC-(ESI)-HRMS, applied to three-spined sticklebacks exposed to diclofenac

HAL (Le Centre pour la Communication Scientifique Directe) (2021)

Emmanuelle Lebeau-Roche Gaëlle Danièle Aurélie Fildier Cyril Turiès Anne Bado‐Nilles

Diclofenac

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Erythrocyte antioxidant enzyme activities in coal miners from three French regions

International Archives of Occupational and Environmental Health (1998)

Rachel Nadif Jean‐Marc Porcher Martine Dusch Jean‐Marie Mur Guy Auburtin

Pneumoconiosis

10.1007/s004200050278

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A bioenergetics model of the entire life cycle of the three‐spined stickleback, gasterosteus aculeatus

Ecology Of Freshwater Fish (2016)

Charlène Leloutre A. Pery Jean‐Marc Porcher Rémy Beaudouin

Abstract A whole life‐cycle bioenergetic model based on the dynamic energy budget ( DEB ) theory was proposed for the three‐spined stickleback ( Gasterosteus aculeatus ). To develop this model, experiments on growth and reproduction were performed: adult and juvenile growth, size at first reproduction and amount of eggs spawned by females were monitored under different feeding levels and temperatures. The DEB parameters were estimated, using Bayesian statistics, based on the data produced during these experiments and on other data found in the literature. The model fitted accurately the different data used for the calibration process and, in addition, predicted accurately the data sets used to assess its predictability. Our bioenergetic model of the whole life cycle of the three‐spined stickleback accounting for environmental variations could contribute in many ways to improved ecological assessment: supporting change of scale from individual to populations; developing new biomarkers of exposure and effect; analysing ecotoxicity tests with biology‐based models.

Three-spined stickleback

Bioenergetics

Predictability

Energy budget

Allometry

10.1111/eff.12329

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Citations (11)

Evaluation et caractérisation des effets du diclofénac sur l’épinoches à trois épines, basées sur une approche métabolomique non ciblée

HAL (Le Centre pour la Communication Scientifique Directe) (2021)

Emmanuelle Lebeau-Roche Gaëlle Danièle Aurélie Fildier Christelle Bonnefoy Cyril Turiès

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