Anjali Jhingan

National Skin Centre

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Steven Tien Guan Thng

National Skin Centre

Sai Yee Chuah

National Skin Centre

Wei‐Sheng Chong

National University of Malaysia

Joseph Jia Hong Toh

National Skin Centre

Joseph Jia‐Hong Toh

National Skin Centre

Hui Mei Cheng

National Skin Centre

Nasrine Bourokba

L'Oréal (France)

Tarun Chopra

A. Khemis

Hôpital Privé Jacques Cartier

Thierry Passeron

Inserm

Cooperative Institutions

National Skin Centre

Singapore Centre for Environmental Life Sciences Engineering

L'Oréal (France)

Nanyang Technological University

National University of Singapore

Agency for Science, Technology and Research

Singapore General Hospital

Changi General Hospital

Hôpital l'Archet

Université Côte d'Azur

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Terra Firma-Forme Dermatosis in Singaporean Patients: The "Alcohol Wipe" Sign.

PubMed (2016)

Choon Chiat Oh Hazel H. Oon See Ket Ng Shang‐Ian Tee Anjali Jhingan

The term terra firma-forme dermatosis arises from the Latin phrase terra firma, meaning dry land (dirt), thus implying dirt-like dermatosis. The authors highlight five cases of patients with terra firma-forme dermatosis presenting to our dermatology center between 2012 and 2013. All patients presented to the dermatologist for persistent reticulated brown patches on the skin. These patients ranged in age from 6 to 22 years. All patients had tried various cleansing soaps and agents but were unable to remove the patches. The condition was cosmetically unacceptable to the patients and parents. Clinically, these patients had reticulated brown patches. Rubbing 70% isopropyl alcohol wipes on the affected areas demonstrated clearance of the brown pigmented patches in all cases. The diagnosis of terra firma-forme dermatosis (TFFD) was confirmed by forceful rubbing with a gauze pad immersed in 70% isopropyl alcohol or ethyl alcohol. Patients should be reassured about the benign nature of TFFD and educated about the cleaning procedure. Recognition of this condition can assist physicians in making a diagnosis and therapy with a simple alcohol wipe, preventing further unnecessary tests for patients.

Dirt

Isopropyl alcohol

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Citations (4)

Afamelanotide implants and narrow-band ultraviolet B phototherapy for the treatment of nonsegmental vitiligo in Asians

Journal of the American Academy of Dermatology (2020)

Joseph Jia Hong Toh Sai Yee Chuah Anjali Jhingan Wei‐Sheng Chong Steven Tien Guan Thng

Vitiligo

Ultraviolet b

10.1016/j.jaad.2020.01.035

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Citations (20)

Lichen amyloidosis in an unusual location.

Singapore Medical Journal (2007)

Anjali Jhingan J S S Lee S. Prasad Kumarasinghe

We report lichen amyloidosis occurring on the upper lip and nasolabial folds of a 61-year-old woman from Singapore. She had a past history of systemic lupus erythematosus, which was in remission for three years. There had been no lesions of lupus erythematosus in this area. Clinically, the lesions were skin-coloured, firm papules and our differential diagnoses included trichoepithelioma, papular sarcoid or lupus miliaris disseminatus faciei. Skin biopsy from one of the lesions showed amyloid deposits in the dermis which were Congo red stain positive. These deposits also showed apple green birefringence. Immunohistochemical staining of the amyloid deposits stained positive for cytokeratins (CK) 5 and 6, and negative for CK 14. The kappa and lambda stains were equivocal. Further investigations, including multiple myeloma screen and rectal biopsy, ruled out systemic amyloidosis. There was no other evidence of cutaneous amyloidosis on her limbs or trunk. She refused treatment for her lesions. This case highlights the commonly-seen form of primary localised cutaneous amyloidosis in an unusual location.

Trichoepithelioma

Skin biopsy

Amyloid (mycology)

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Decoding scalp health and microbiome dysbiosis in dandruff

bioRxiv (Cold Spring Harbor Laboratory) (2024)

Viduthalai R. Regina Tarun Chopra Kwok Weihao Sreelakshmi Cheruvalli Ang Sabrina

Abstract A balanced scalp microbiome is crucial for scalp health, yet the mechanisms governing this balance and the etiology of dysbiosis in scalp disorders remain elusive. We conducted a detailed investigation of the scalp and hair follicles, in healthy individuals and those with dandruff/seborrheic dermatitis (D/SD). It was demonstrated that the microbiome inhabiting hair follicles serves as a reservoir for the scalp microbiome, thereby integrating the scalp, follicle, and the hair into one functional unit. Using in vitro models, we further elucidated mechanisms governing the assembly and interactions of the follicular microbiome under healthy and D/SD conditions. We show that propionic acid, produced by C. acnes , plays a pivotal role in maintaining microbiome balance, with implications for scalp health, which was validated through a clinical study.

Dandruff

Dysbiosis

Malassezia

10.1101/2024.05.02.592279

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Citations (1)

Chemo-inflammation-an effective treatment for freckles.

Indian Journal of Dermatology Venereology and Leprology (1999)

J S Pasricha Paschal D’ Souza Akhil Sood Anjali Jhingan

Freckles are fairly common and considered to be incurable. We have developed a new technique called "Chemo-inflammation" with which we have treated 5 patients (4 girls and one boy) having extensive freckles with excellent results. All the freckles disappeared completely from the treated areas and there has been no recurrence so far. The technique consists of applying a liquid based on an alkyl sulphate, on the affected skin and repeating the application every hour for a day till the entire skin develops adequate inflammation. The liquid is then washed off with tap water and the skin is treated with topical (or systemic) corticosteroids till the inflammation subsides and the treated skin peels off and attains its normal texture. This generally happens within a week or so. Post-inflammatory hyperpigmemation has to be prevented by adequate anti-inflammatory treatment. Otherwise there are no precautions.

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A retrospective clinico‐pathological study comparing lichen planus pigmentosus with ashy dermatosis

Australasian Journal of Dermatology (2018)

Hui Mei Cheng Sai Yee Chuah Emily Yiping Gan Anjali Jhingan Steven Tien Guan Thng

Abstract Background/Objectives Controversy persists as to whether lichen planus pigmentosus and ashy dermatosis are separate clinical entities. This study was conducted to examine the clinicopathological features and treatment outcome of the two conditions. Methods A retrospective medical chart review of all patients who were diagnosed with lichen planus pigmentosus or ashy dermatosis was conducted. The information collected included the participants’ age at onset, site of onset, duration of disease, presence of precipitating factors, distribution of disease, pigmentation and presence of symptoms. In patients from whom a biopsy was taken the histopathological reports were included. Results Altogether 26 patients with ashy dermatosis and 29 with lichen planus pigmentosus were included in the study. Compared with ashy dermatosis, lichen planus pigmentosus had a more localised distribution with a preponderance for facial involvement, compared with the truncal preponderance in ashy dermatosis. Ashy dermatosis tended to have a more stable clinical course than lichen planus pigmentosus, which was more likely to wax and wane. The utility of histopathology in differentiating between the two conditions is low. Conclusion Ashy dermatosis and lichen planus pigmentosus, as defined in this study, appear to be two separate clinical entities with distinguishable clinical features and natural histories.

Histopathology

10.1111/ajd.12813

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Citations (38)

Automated scoring of vitiligo using superpixel-generated computerized digital image analysis of clinical photographs: a novel and consistent way to score vitiligo

British Journal of Dermatology (2018)

Joseph Jia‐Hong Toh Suman Bhoi V. W. D. Tan Sai Yee Chuah Anjali Jhingan

Vitiligo

Digital Image Analysis

10.1111/bjd.16563

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Citations (10)

Atorvastatin in Combination With Narrowband UV-B in Adult Patients With Active Vitiligo

JAMA Dermatology (2018)

Sophie Nguyen Sai Yee Chuah Éric Fontas A. Khemis Anjali Jhingan

Studies have reported the anti-inflammatory, immunomodulatory, and antioxidant effects of statins.Targeting motif chemokine CXCL10 using antibodies has been shown to prevent the depigmentation in the vitiligo mouse model. 1 In the same model, simvastatin was effective in the regression of vitiligo. 2Simvastatin has also been shown to protect melanocytes from oxidative stress by activating nuclear factor (erythroid-derived 2)-like 2, 3 and atorvastatin can reduce plasma levels of CXCL10 in patients with Crohn disease. 4Therefore, there is a rationale for using statins to halt the progression of active vitiligo.

Vitiligo

Narrowband

10.1001/jamadermatol.2017.6401

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Citations (26)