Cytomegalovirus (CMV) reactivation is a known complication in patients with hematological cancers and those who undergo stem cell transplants, often resembling cancer relapse. CMV lymphadenitis, an infection localized to the lymph nodes, can be difficult to distinguish from lymphoma recurrence based on clinical and radiological findings alone. We report a case of a 40-year-old male treated for Hodgkin lymphoma who presented with cervical lymphadenopathy nine months after treatment. PET-CT showed a hypermetabolic lesion, suggesting relapse, but a biopsy confirmed CMV lymphadenitis. Systemic CMV infection was excluded based on negative PCR results and normal thoracic imaging. This report highlights the importance of histopathological confirmation in patients with a history of lymphoma, as CMV lymphadenitis can mimic relapse. Accurate diagnosis prevents unnecessary treatments and avoids misinterpretation of imaging findings. In isolated lymph node cases without systemic symptoms, observation may be sufficient as the condition can resolve spontaneously. This underscores the need for careful evaluation to ensure correct diagnosis and appropriate management.
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Abstract A 57-year-old man with familial adenomatous polyposis (FAP) and newly diagnosed colonic adenocarcinoma was referred to 18 F-FDG PET/CT for staging and 68 Ga-FAPI-04 PET/CT for ongoing trial. 18 F-FDG PET/CT showed equal intense 18 F-FDG uptake in the tumor and multiple hypermetabolic polypoid lesions in the entire colorectum. 68 Ga-FAPI-04 PET/CT showed intense 68 Ga-FAPI-04 uptake only at the colonic tumor, without uptake at polypoid lesions.
Abstract Background and Aims: The International Serous Fluid Cytopathology Reporting System aimed to establish standardized protocols to ensure consistency in the reporting of serous fluid cytological specimens. In the search for higher diagnostic accuracy and a reduction in indeterminate categories, such as atypia of undetermined significance (AUS), ancillary tests like immunohistochemical (IHC) staining panels were performed. In our study, we aimed to evaluate whether the category of cases diagnosed as AUS by initial examination would change at the end of IHC studies. Materials and Methods: In total, 375 serous fluid cytology samples were examined in our laboratory for 10 months. Of these, 37 cases that were initially diagnosed as AUS were included in the study. A control group, comprising 20 cases initially diagnosed as negative for malignancy (NFM) was used. For the IHC study, sections from cell blocks were used for each group Then, the slides were stained with Ep-CAM/epithelial specific antigen (MOC31), Hector Battifora mesothelial-1 (HBME-1), and cluster of differentiation 68 (CD68). Results: Following the IHC study involving MOC31, HBME-1, and CD68, a significant reclassification was observed in cases initially diagnosed as AUS. Specifically, in 86.1% of these cases, a definitive categorization into either NFM or malignant was achieved. Statistical analysis revealed a significant difference between the two groups in terms of achieving a definitive category after the IHC study ( P < 0.05). Conclusion: Our study emphasizes the critical importance of enhancing the initial IHC panel, initially composed of epithelial and mesothelial markers, with CD68. This strategic addition contributed significantly to the reduction of cases categorized as AUS.
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Ramadan S, Saka B, Yarikkaya E, Bilici A, Oncel M. The potential prognostic role of peritumoral eosinophils within whole tumor-associated inflammatory cells and stromal histological characteristics in colorectal cancer. Polish Journal of Pathology. 2020;71(3):207-220. doi:10.5114/pjp.2020.99787. APA Ramadan, S., Saka, B., Yarikkaya, E., Bilici, A., & Oncel, M. (2020). The potential prognostic role of peritumoral eosinophils within whole tumor-associated inflammatory cells and stromal histological characteristics in colorectal cancer. Polish Journal of Pathology, 71(3), 207-220. https://doi.org/10.5114/pjp.2020.99787 Chicago Ramadan, Saime, Burcu Saka, Enver Yarikkaya, Ahmet Bilici, and Mustafa Oncel. 2020. "The potential prognostic role of peritumoral eosinophils within whole tumor-associated inflammatory cells and stromal histological characteristics in colorectal cancer". Polish Journal of Pathology 71 (3): 207-220. doi:10.5114/pjp.2020.99787. Harvard Ramadan, S., Saka, B., Yarikkaya, E., Bilici, A., and Oncel, M. (2020). The potential prognostic role of peritumoral eosinophils within whole tumor-associated inflammatory cells and stromal histological characteristics in colorectal cancer. Polish Journal of Pathology, 71(3), pp.207-220. https://doi.org/10.5114/pjp.2020.99787 MLA Ramadan, Saime et al. "The potential prognostic role of peritumoral eosinophils within whole tumor-associated inflammatory cells and stromal histological characteristics in colorectal cancer." Polish Journal of Pathology, vol. 71, no. 3, 2020, pp. 207-220. doi:10.5114/pjp.2020.99787. Vancouver Ramadan S, Saka B, Yarikkaya E, Bilici A, Oncel M. The potential prognostic role of peritumoral eosinophils within whole tumor-associated inflammatory cells and stromal histological characteristics in colorectal cancer. Polish Journal of Pathology. 2020;71(3):207-220. doi:10.5114/pjp.2020.99787.
Ependymomas are central nervous system neoplasms that account for a third of all posterior fossa tumors in children. The most common location for infratentorial ependymoma is within the fourth ventricle. We present a case report of malignant transformation of an infratentorial grade II ependymoma in a 2-year-old child who presented with vomiting and visual disturbance. An infratentorial brain tumor in the left cerebellar area was totally removed, and the initial pathologic diagnosis was grade II ependymoma. The tumor recurred aggressively 1 year later; subtotal removal and adjuvant chemotherapy were performed. After a second operation, a histopathologic study was performed. The second specimen was defined as a grade III anaplastic ependymoma. Transformation to grade III anaplastic ependymoma is possible for a grade II ependymoma but very rare. The diagnosis of the anaplastic variant of intracranial ependymomas is difficult. Surgical treatment remains the mainstay of the treatment for all cases. Ependymomas in young infants have a worse prognosis than older children, so we need individual clinical evaluation and close follow-up of such cases. This article highlights the requirement of a close follow-up for grade II ependymomas for anaplastic transformation.