Alessandra Tavani

University of Milan

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Co-Authors

Carlo La Vecchia

University of Milan

234

Eva Negri

University of Milan

117

Silvia Franceschi

Istituti di Ricovero e Cura a Carattere Scientifico

Cristina Bosetti

Mario Negri Institute for Pharmacological Research

Silvano Gallus

Mario Negri Institute for Pharmacological Research

Renato Talamini

Pontifícia Universidade Católica do Paraná

Luigino Dal Maso

Centro di Riferimento Oncologico

Claudio Pelucchi

University of Milan

Diego Serraino

Centro di Riferimento Oncologico

Federica Turati

University of Milan

Cooperative Institutions

Istituti di Ricovero e Cura a Carattere Scientifico

100

University of Milan

Mario Negri Institute for Pharmacological Research

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública

Instituto de Salud Carlos III

Centro di Riferimento Oncologico

National Cancer Institute

Sapienza University of Rome

Centre International de Recherche sur le Cancer

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

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Diabetes Mellitus and the Risk of Prostate Cancer in Italy

European Urology (2004)

Alessandra Tavani Silvano Gallus Michaela Bertuzzi Luigino Dal Maso Antonella Zucchetto

10.1016/j.eururo.2004.10.027

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Citations (40)

Interaction of U-69,593 with μ-, ∂- and k-opioid binding sites and its analgesic and intestinal effects in rats

Life Sciences (1988)

A. La Regina Paola Petrillo M. Sbacchi Alessandra Tavani

μ-opioid receptor

10.1016/0024-3205(88)90638-8

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Citations (36)

Education, socioeconomic status and risk of cancer of the colon and rectum

International Journal of Epidemiology (1999)

Alessandra Tavani Francesca Fioretti Silvia Franceschi Silvano Gallus Eva Negri

BACKGROUND: Socioeconomic correlates of cancer of the large bowel differ in various countries and calendar periods and may differ for the colon and rectum. Thus, the relationship between education and social class and risk of cancers of the colon and rectum was considered. METHODS: Combination of two hospital-based case-control studies conducted in six Italian centres between 1985 and 1996. Cases were 3533 patients aged < 79, with histologically confirmed cancer of the colon (n = 2180) or rectum (n = 1353), and controls were 7062 patients admitted to hospital for a wide spectrum of acute, non-neoplastic, non-digestive tract diseases. RESULTS: Compared to individuals with < 7 years of education the multivariate odds ratios (OR) of colon cancer for those with > or = 16 years were 2.45 (95% confidence interval [CI]: 1.87-3.23) in men and 1.29 (95% CI: 0.88-1.90) in women, with significant trends in risk. No significant association emerged between education and risk of rectal cancer, with OR of 1.18 (95% CI: 0.83-1.70) and 1.01 (95% CI: 0.61-1.67) respectively for men and women in the highest educational category compared to the lowest. Social class was also related to colon cancer risk: the OR were 2.30 (95% CI: 1.82-2.90) in men and 1.33 (95% CI: 1.03-1.73) in women in the highest versus the lowest social class. No association was found between social class and rectal cancer risk, with OR of 1.18 for either men or women in the highest as compared to the lowest social class. No significant heterogeneity was found for the association between education and colon cancer risk in either sex across strata of age at diagnosis, coffee, alcohol and vegetable intake, family history of the disease, and in anatomical subsites within the colon. CONCLUSION: This study, based on a uniquely large dataset, indicates that there are different social class correlates for colon and rectal cancer. Consequently the two sites should not be combined in studies considering lifestyle factors in the aetiology of these neoplasms.

10.1093/ije/28.3.380

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Citations (42)

The (+)-enantiomer is responsible for the antiplatelet and anti-inflammatory activity of (±)-indobufen

Journal of Pharmacy and Pharmacology (1990)

Chiara Cerletti Stefano Manarini Monica Colombo Alessandra Tavani

Abstract The racemic compound indobufen and its (+)-and (—)-enantiomers have been compared for their effects on blood platelet function and rat carrageenan pleurisy. The antiplatelet properties were studied in-vitro in human platelets by measuring the inhibition of platelet aggregation and generation of serum thromboxane (Tx) B2. In-vivo, the antiplatelet and anti-inflammatory properties were studied in rats by measuring the inhibition of serum TxB2, the amount of 6-keto-PGF1α in pleural exudate and pleural exudate volume. In all tests the (+)-enantiomer was slightly more potent than the racemate, while the (—)-enantiomer was far less potent. In the same rats, treatment with the lowest doses of the compounds giving 90% inhibition of serum thromboxane B2 generation was associated with occasional macroscopic lesions of the gastric mucosa.

Thromboxane B2

Exudate

Ex vivo

Pleurisy

Carrageenan

10.1111/j.2042-7158.1990.tb07049.x

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Citations (24)

Alcohol Consumption and Acute Myocardial Infarction: A Benefit of Alcohol Consumed With Meals?

Epidemiology (2004)

Livia S. A. Augustin Silvano Gallus Alessandra Tavani Cristina Bosetti Eva Negri

The apparent favorable effect of alcohol on the risk of acute myocardial infarction (MI) may be related to its hypoinsulinemic effect when consumed with meals. We studied how the timing of alcohol consumption in relation to meals might affect the risk of MI in a population with relatively high regular alcohol consumption.We conducted a case-control study between 1995 and 1999 in Milan, Italy. Cases were 507 subjects with a first episode of nonfatal acute MI, and controls were 478 patients admitted to hospitals for other acute diseases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by multiple logistic regression models.Compared with nondrinkers, an inverse trend in risk was observed when alcohol was consumed during meals only (for > or =3 drinks per day: OR = 0.50; 95% CI = 0.30-0.82). In contrast, no consistent trend in risk was found for subjects drinking outside of meals (for > or =3 drinks per day: 0.98; 0.49-1.96). The pattern of risk was similar when we considered people who drank only wine.Alcohol drinking during meals was inversely related with risk of acute MI, whereas alcohol drinking outside meals only was unrelated to risk.

Consumption

10.1097/01.ede.0000142146.36594.9a

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Citations (20)

Activity profiles of opiates at the μ-, δ- and kappa-binding sites

British Journal of Pharmacology (1981)

H. W. Kosterlitz Jacques Magnan Sue Paterson Alessandra Tavani

Kappa

Source

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Citations (1)

Allium vegetables and upper aerodigestive tract cancers: a meta‐analysis of observational studies

Molecular Nutrition & Food Research (2015)

Valentina Guercio Federica Turati Carlo La Vecchia Carlotta Galeone Alessandra Tavani

To provide updated quantitative overall estimations of the relation between total allium, garlic, and onion intake on the risk of cancer of the upper aerodigestive tract (UADT).We combined data of published observational studies (21 case-control and four cohort studies), using a meta-analytic approach and random effects models. The overall relative risks (RR) and 95% confidence intervals (CIs) for the squamous cell carcinoma of the UADT were 0.79 (95% CI 0.56-1.11) for total allium, 0.74 (95% CI 0.57-0.95) for garlic, and 0.72 (95% CI 0.57-0.91) for onion for the highest versus the lowest consumption. The inverse relation was apparently stronger in case-control studies (RR 0.56, 95% CI 0.38-0.83 for total allium), in Chinese studies (RR 0.67, 95% CI 0.45-0.98 for garlic intake), and for esophageal than for head and neck cancers. Apparently, there was no relation between allium vegetable intake and adenocarcinoma of the esophagus.We found a moderate inverse association between allium vegetable intake and the risk of squamous cell carcinoma of the UADT in case-control studies. The relation was unclear in cohort studies and for adenocarcinoma of the esophagus.

10.1002/mnfr.201500587

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Citations (30)

Does Coffee Protect Against Liver Cirrhosis?

Annals of Epidemiology (2002)

Silvano Gallus Alessandra Tavani Eva Negri Carlo La Vecchia

10.1016/s1047-2797(01)00304-0

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Citations (98)

Colorectal Cancer and Disinfection Byproducts in Italy and Spain

Epidemiology (2010)

Cristina M. Villanueva Cristina Bosetti Elena Righi Vı́ctor Moreno Carlo La Vecchia

S-31B8-3 Background/Aims: Experimental data suggest that disinfection byproducts (DBPs) are colorectal carcinogens but epidemiological evidence is contradictory. To evaluate colorectal cancer risk associated with long-term DBP exposure. Methods: A case-control study was conducted in Italy and Spain. Cases were newly diagnosed and histologically confirmed, aged 20–85 years, and living in the study areas. Controls were matched to cases by age, gender, and area of residence. Study area comprised Barcelona (Spain) and Milan, Pordenone and Udine (Italy). Study subjects were interviewed on potential risk factors of colorectal cancer, residential history and water uses including ingestion, showering, bathing, dishwashing, and swimming in pools. Blood samples were collected to obtain DNA sample. Retrospective data on trihalomethane levels in the study areas have been collected through water companies, and water samples have been collected to measure a range of DBPs. Results: Based on 500 cases and 436 controls in Spain and 400 cases and 363 controls in Italy, the longest residence lasted 35 years on average in Spain and 37 years in Italy. Drinking water at the longest residence was from public water supply among 56% subjects in Spain and 46% in Italy. The rest consumed bottled water or from other sources. Those drinking water from public supplies compared to bottled water had an odds ratio and 95% confidence interval of 1.17 (0.87–1.58) in Spain and 1.18 (0.79, 1.77) in Italy, adjusting for potential confounders. Taking long compared to short showers (above vs. below median) yield an odds ratio of 1.04 (0.80–1.40) in Spain and 1.16 (0.83–1.63) in Italy. Mean trihalomethane levels in Italy were <10 μg/L and ranged from 17.6 to 134 μg/L in Spain. Residential trihalomethane level was associated with an increased colorectal cancer risk for some exposure categories without a clear dose-response. Conclusion: These initial results suggest a weak association between colorectal cancer and DBP exposure.

Bathing

Trihalomethane

Bottled water

Northern italy

10.1097/01.ede.0000392150.43256.39

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Citations (1)

Effect of [D-Ala2,MePhe4,Gly-ol5]enkephalin and [D-Ala2,D-Leu5]enkephalin on ion and amino acid transport in rabbit ileum

Journal of Pharmacy and Pharmacology (1989)

G. Meyer Guido Fernando Botta Alessandra Tavani S Algeri D. Cremaschi

Abstract The selective μ-opioid agonist [D-Ala2,MePhe4, Gly-ol5]enkephalin (DAGO) (10 μM) reduced the short circuit (Isc) and the L-valine induced increase of the transepithelial potential difference and Isc(δVms and δsc) measured in-vitro in rabbit ileum, with a mechanism antagonized by naloxone (1 μM). [D-Ala2, D-Leu5]enkephalin (DADLE) (10 μM) had no significant effect on the transepithelial potential difference (Vms), Isc, δVms and δIsc. In the ileum deprived of the serosa and muscolaris, DAGO reduced the δVms and δIsc, but not the Vms and Ics, suggesting localization of the receptors responsible for this latter effect in the myenteric plexus and/or the muscularis mucosae. These preliminary results suggest that in the rabbit ileum opioids influence electrolyte and amino acid transport and these effects may be at least partly mediated by μ-receptors.

DADLE

DAMGO

μ-opioid receptor

10.1111/j.2042-7158.1989.tb06510.x

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Citations (2)