Hazuki Endo

Tokyo Medical and Dental University

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Shigeomi Shimizu

Tokyo Medical and Dental University

Masatsune Tsujioka

Tokyo Medical and Dental University

Satoko Arakawa

Institute of Science Tokyo

Satoru Torii

Tokyo Medical and Dental University

Shinya Honda

Tokyo Medical and Dental University

Masatsune Tujioka

Meruna Nagata

Tokyo Medical and Dental University

Hirofumi Yamaguchi

Tohoku University

Akimitsu Konishi

Gunma University

Yuya Nishida

Juntendo University

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Tokyo Medical and Dental University

The University of Tokyo

Osaka University

Institute of Science Tokyo

Japan Science and Technology Agency

National Institute of Advanced Industrial Science and Technology

Kyoto University

Pathological Society

Tohoku University

RIKEN Center for Computational Science

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Dram1 regulates DNA damage-induced alternative autophagy

Cell Stress (2018)

Meruna Nagata Satoko Arakawa Hirofumi Yamaguchi Satoru Torii Hazuki Endo

Autophagy is an evolutionarily conserved process that degrades subcellular constituents. Mammalian cells undergo two types of autophagy; Atg5-dependent conventional autophagy and Atg5-independent alternative autophagy, and the molecules required for the latter type of autophagy are largely unknown. In this study, we analyzed the molecular mechanisms of genotoxic stress-induced alternative autophagy, and identified the essential role of p53 and damage-regulated autophagy modulator (Dram1). Dram1 was sufficient to induce alternative autophagy. In the mechanism of alternative autophagy, Dram1 functions in the closure of isolation membranes downstream of p53. These findings indicate that Dram1 plays a pivotal role in genotoxic stress-induced alternative autophagy.

10.15698/cst2018.03.127

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Analysis of anoikis in non-apoptotic cell death

The Japanese Biochemical Society/The Molecular Biology Society of Japan (2017)

Hazuki Endo Masatsune Tsujioka Shigeomi Shimizu

Anoikis

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Identification of non-apoptotic anoikis

The Molecular Biology Society of Japan (2016)