G M Reynolds

University of Birmingham

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David H. Adams

Icahn School of Medicine at Mount Sinai

S.G. Hübscher

University of Birmingham

Gideon M. Hirschfield

University Health Network

Arianeb Mehrabi

Heidelberg University

Martti Färkkilâ

Helsinki University Hospital

Patricia F. Lalor

National Institute for Health Research

Cheville Jc

Mayo Clinic

Des C. Jones

AstraZeneca (United Kingdom)

Jeremy Tomlinson

Oxford Centre for Diabetes, Endocrinology and Metabolism

Lawrence S. Young

University of Warwick

Cooperative Institutions

University of Birmingham

Heidelberg University

University Hospital Heidelberg

Universität Hamburg

University of Oslo

German Cancer Research Center

NIHR Birmingham Liver Biomedical Research Unit

Heidelberg University

National Center for Tumor Diseases

NIHR Birmingham Biomedical Research Centre

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Lymphocyte interactions with hepatocytes: distinct mechanisms for T and B cells

Immunology (2011)

Zania Stamataki Omar Qureshi G M Reynolds Linda Hibbert Jennifer A. Waters

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Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals novel therapeutic opportunities

Zeitschrift für Gastroenterologie (2020)

Benjamin Goeppert Trine Folseraas Stephanie Roessler Matthias Kloor AL Volckmar

The lifetime risk of biliary tract cancer (BTC) in primary sclerosing cholangitis (PSC) patients exceeds 20% and BTC is currently the leading cause of death in PSC patients. To open new avenues for management of PSC-associated BTC (PSC-BTC), we aimed to delineate novel and clinically relevant genomic and pathological features of a large cohort of PSC-BTC tumor tissues.

Primary Sclerosing Cholangitis

Biliary Tract Cancer

10.1055/s-0039-3402199

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Citations (3)

Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector

Gene Therapy (2004)

Mei‐Jou Chen N K Green G M Reynolds J R Flavell Vivien Mautner

Oncolytic adenovirus

Nitroreductase

Suicide gene

10.1038/sj.gt.3302271

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Citations (43)

Balance between exhausted regulatory T cells and CD161(+) NK cells is crucial in acute AIH pathogenesis

HC Jeffery M K Braitch S.G. Hübscher G M Reynolds LL Wong

Pathogenesis

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T-cell lymphosarcoma in a female African green monkey (Cercopithecus aethiops).

PubMed (1990)

Manuel J. Jayo Kathy Laber B C Bullock Hermina Tulli G M Reynolds

A female African green monkey developed a generalized lymphosarcoma spontaneously that clinically and pathologically resembled malignant lymphoma in human beings infected with human T-lymphotropic virus type I. The monkey was serologically positive for simian T-lymphotropic virus. Immunocytochemical analysis of routinely fixed and paraffin embedded tumor tissue demonstrated neoplastic cells that stained positive with antihuman monoclonal UCHL1 which recognized a T-cell-restricted isotype of leukocyte common antigen.

African Green Monkey

Cercopithecus aethiops

Simian

Human T-lymphotropic virus

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Citations (11)

Vascular adhesion protein-1 promotes progression of steatohepatitis by expansion of the intrahepatic CD4+AND NKT cell populations and induction of fibrogenesis

L C Claridge CJ Weston EL Haughton Nina Westerlund G M Reynolds

Steatohepatitis

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