Freestone, D. S. (Dept. Clinical Immunology, The Wellcome Research Laboratories, Beckenham, Kent, BR3 3BS, England), D. F. Rowlands and J. Prydie. History of infection and immunity to rubella. Am J Epidemiol. 96: 70–73, 1972.—In 13-year-old schoolgirls, good correlations were found between a recent history of rubella and the presence of hemag-glutinating inhibiting (HI) antibody, but the correlations declined progressively as the history of rubella became more remote. These findings suggest a progressive fall in antibody titer, or diminished historical accuracy with passage of time. However, the lower geometric mean HI antibody titers in those groups of girls with less recent histories of infection support the first probability. Furthermore, in seronegative schoolgirls with a history of rubella more than four years earlier, the seroconversion rate to subcutaneously administered live attenuated rubella vaccine was lower than that seen in seronegative girls with no past history of rubella.
This study of 724 13-year-old schoolgirls in the County Borough of Reading showed that approximately 25% were susceptible to rubella. 96.1% of the 129 seronegative girls and significant numbers of girls with low rubella HAI antibody titres responded to subcutaneous vaccination with Wistar RA. 27/3 rubella vaccine. The incidence of most reactions after vaccination was similar in those who responded to vaccine and those who were initially immune but did not develop rising antibody titres, but rash, lymphadenopathy and headache occurred significantly more frequently in the susceptible group.
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