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YO

Yasuyuki Ogawa

Stanford University

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Teruaki Mukaiyama

Tokyo University of Science

Kiichi Kuroda

Sumitomo Dainippon Pharma (Japan)

Shosuke Yamamura

Keio University

Ken Ohmori

Tokyo Institute of Technology

Shigeru Nishiyama

Saku Central Hospital

Tetsuo Obitsu

Ono Pharmaceutical (Japan)

Yuichi Ishikawa

Akita Prefectural University

Jun‐ichi Matsuo

Kanazawa University

Keiji Hashimoto

Stony Brook University

Shojiro Miyazaki

Daiichi-Sankyo (Japan)

Cooperative Institutions

Daiichi-Sankyo (Japan)

Daiichi Sankyo (Germany)

The University of Tokyo

Amgen (United States)

Keio University

Kyoto University

University of Tsukuba

Stanford University

Hokkaido University

Tokyo Institute of Technology

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Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists

Bioorganic & Medicinal Chemistry Letters (2017)

Takehiko Iwaki Yuji Nakamura Taisaku Tanaka Yasuyuki Ogawa Osamu Iwamoto

Quinazoline

Structure–activity relationship

10.1016/j.bmcl.2017.09.028

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Citations (7)

Highly Stereoselective Samarium(II) Iodide‐Mediated Aldol Reactions of Acylaziridines with Aldehydes.

ChemInform (2005)

Yasuyuki Ogawa Kiichi Kuroda Teruaki Mukaiyama

Abstract For Abstract see ChemInform Abstract in Full Text.

Aldol reaction

10.1002/chin.200546026

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(+)-3-{(4S,5S)-5-[1,1-Dimethyl-2-(phenylthio)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}prop-2-yn-1-ol

Acta Crystallographica Section C Crystal Structure Communications (2000)

H. Hosomi Shigeru Ohba Ken Ohmori Tetsuo Obitsu Yasuyuki Ogawa

10.1107/s0108768100003372

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103. The spectrometries of photoneutrons from lineac in 10, 15, 18MVX-Ray institutes by Buble-detectores

Japanese Journal of Radiological Technology (1993)

Yasuyuki Ogawa Yasuo Kondo Keiji Hashimoto Eriko Honda Satoru Matuo

10.6009/jjrt.kj00003501148

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Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors

Bioorganic & Medicinal Chemistry Letters (2012)

Yutaka Mori Yasuyuki Ogawa Akiyoshi Mochizuki Yuji Nakamura Chie Sugita

Piperidine

Carboxamide

10.1016/j.bmcl.2012.09.103

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Citations (9)

208. The spectrometry on ieakage of photoneutron by bubledetector

Japanese Journal of Radiological Technology (1992)

Yasuo Kondo Keiji Hashimoto Eriko Honda Satoru Matuo T Kida

10.6009/jjrt.kj00003500604

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Emission Behavior of Secondary Thioamide‐Based Cationic Pincer Platinum(II) Complexes in the Aggregate State

European Journal of Inorganic Chemistry (2014)

Hiroya Honda Yasuyuki Ogawa Junpei Kuwabara Takaki Kanbara

Abstract Cationic pincer platinum(II) complexes bearing secondary thioamide units showed aggregation‐induced emission (AIE) activity in chloroform/hexane and methanol/water mixtures. Hydrogen bonding of the thioamide units and interionic interactions contributed to the AIE activities.

Thioamide

Cationic polymerization

10.1002/ejic.201301404

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Citations (26)

Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor

ACS Medicinal Chemistry Letters (2012)

Yuji Nakamura Teppei Fujimoto Yasuyuki Ogawa Chie Sugita Shojiro Miyazaki

A novel orally bioavailable renin inhibitor, DS-8108b (5), showing potent renin inhibitory activity and excellent in vivo efficacy is described. We report herein the synthesis and pharmacological effects of 5 including renin inhibitory activity in vitro, suppressive effects of ex vivo plasma renin activity (PRA) in cynomolgus monkey, pharmacokinetic data, and blood pressure-lowering effects in an animal model. Compound 5 demonstrated inhibitory activities toward human renin (IC50 = 0.9 nM) and human and monkey PRA (IC50 = 1.9 and 6.3 nM, respectively). Oral administration of single doses of 3 and 10 mg/kg of 5 in cynomolgus monkey on pretreatment with furosemide led to dose-dependent significant reductions in ex vivo PRA and sustained lowering of mean arterial blood pressure for more than 12 h.

Renin inhibitor

Plasma renin activity

Ex vivo

IC50

10.1021/ml300168e

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Citations (13)

Totalsynthese von Bryostatin 3

Angewandte Chemie (2000)

Ken Ohmori Yasuyuki Ogawa Tetsuo Obitsu Yuichi Ishikawa Shigeru Nishiyama

Bryostatin 1

10.1002/1521-3757(20000703)112:13<2376::aid-ange2376>3.0.co;2-5

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Citations (35)

Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors

Bioorganic & Medicinal Chemistry (2013)

Yutaka Mori Yasuyuki Ogawa Akiyoshi Mochizuki Y. Nakamura Teppei Fujimoto

Piperidine

hERG

Renin inhibitor

Orally active

10.1016/j.bmc.2013.06.057

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Citations (10)