Babak Arjmand

Tehran University of Medical Sciences

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Bagher Larijani

Tehran University of Medical Sciences

122

Mostafa Rezaei‐Tavirani

Shahid Beheshti University of Medical Sciences

Hamid Reza Aghayan

Tehran University of Medical Sciences

Parisa Goodarzi

Tehran University of Medical Sciences

Sepideh Alavi-Moghadam

Tehran University of Medical Sciences

Moloud Payab

Tehran University of Medical Sciences

Akram Tayanloo-Beik

Tehran University of Medical Sciences

Kambiz Gilany

Motamed Cancer Institute

Fakher Rahim

Hazara University

Mohammad Rostami‐Nejad

Shahid Beheshti University of Medical Sciences

Cooperative Institutions

Tehran University of Medical Sciences

304

Shahid Beheshti University of Medical Sciences

117

University of Tehran

Academic Center for Education, Culture and Research

University of Nebraska Medical Center

Iran University of Medical Sciences

Hudson Institute

Shariati Hospital

Imam Khomeini Hospital

Tarbiat Modares University

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Identification of Targeted Central Genes (IGF1 and HMOX1) by Indirect Cold Physical Plasma in Human Melanocytes

Journal of lasers in medical sciences (2022)

Reza Vafaee Babak Arjmand Maryam Hamzeloo‐Moghadam Zahra Razzaghi Mostafa Rezaei‐Tavirani

Introduction: Cold physical plasma is a growing tool in medicine which is applied for the treatment of different cancers. In the present study, the gene profiles of human melanocytes exposed to indirect cold physical plasma versus control individuals are analyzed via protein-protein interaction (PPI) network analysis. Methods: The gene expression profiles were derived from Gene Expression Omnibus (GEO), and the significant differentially expressed genes (DEGs) were decoded via "Expression Atlas". PPI network analysis was applied to find the targeted central genes by indirect cold physical plasma. Results: The main connected component of the constructed network including 74 queried DEGs and 50 added first neighbors was analyzed. Considering degree value, betweenness centrality, closeness centrality, and stress, IGF1 and HMOX1 were introduced as the central nodes. Conclusion: The finding of this study indicates that the down-regulation of IGF1 and the up-regulation of HMOX are the prominent events in response to indirect cold physical plasma treatment at the cellular level. Detection of related biological terms via gene ontology is suggested.

Gene regulatory network

10.34172/jlms.2022.70

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Assessment of Schwann cell purity cultured in autologous human serum for spinal cord injury repair

KAUMS Journal (2010)

Babak Arjmand Sayyead Hamidreza Aghayan Alireza P. Shabanzadeh Abbas Norouzi‐Javidan Hoshang Saberi

Background: Purity of cultured Schwann cell is very important in patients’ outcome. The purpose of this study was evaluation of cell purity in a culture without nerve growth factors and fetal bovine serum. Materials and Methods: In this experimental study, for culture of human Schwann cells, nerve growth factors and fetal bovine serum were replaced by human autologous serum. Obtaining a consent from the close relative, nerve grafts were harvested and transported to processing unit where they were cultured in DMEM upon aseptic condition. Then the cultured cells were evaluated with S100 antibody staining for both morphology and purity. Results: Cell purity range was from 97% to 99% (mean=98.11±0.782%). Cell count was 14055.56±2480.479 per microliter. There was not significant correlation between cell purity with either the culture period or the age of donors (P>0.05). The Spearman correlation coefficient for the cell purity with the culture period and the age of donors was -0.21 and -0.09, respectively. Conclusion: We found that the replacement of nerve growth factors and fetal bovine serum with human autologous serum improves the cultured Schwann cells for clinical use with more safety and minimum reagents. Keywords: Purity, Blood serum, Schwann cells, Spinal cord

Fetal bovine serum

Schwann cell

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EGR1 Is a Critical Gene in Response of Human Keratinocyte to Blue Light Radiation

Journal of lasers in medical sciences (2021)

Maryam Hamzeloo‐Moghadam Mostafa Rezaei‐Tavirani Mohhamadreza Razzaghi Sina Rezaei Tavirani Nahid Safari‐Alighiarloo

Introduction: Investigating the molecular mechanism of cellular response to light radiation has attracted many researchers' attention. In the present study, the critically affected gene by 7.5 min blue light radiation in human keratinocytes was investigated via network analysis. Methods: Gene expression profiles of human keratinocytes exposed to 7.5 min blue light radiation plus controls were extracted from Gene Expression Omnibus (GEO). The significant dysregulated genes plus 100 first neighbors were investigated by Cytoscape software and its applications. The central nodes of the network based on four centrality parameters were determined and discussed. Results: Among 6 significant dysregulated genes, 4 individuals were recognized by the STRING database. The network was constructed by using the 4 queried genes and 100 first neighbors. EGR1, STAT1, and ISG15 were identified as central nodes; however, the prominent role of EGR1 was highlighted. Conclusion: EGR1 appeared as a critically affected gene after blue light irradiation. It seems that this upregulated gene is responsible for protecting human keratinocytes against stress and cancer. Therefore, the application of blue light may be accompanied by antistress effects in the human body.

EGR1

ISG15

10.34172/jlms.2021.83

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Association of amino acid metabolites with osteoporosis, a metabolomic approach: Bushehr elderly health program

Metabolomics (2022)

Nekoo Panahi Noushin Fahimfar Shahin Roshani Babak Arjmand Safoora Gharibzadeh

10.1007/s11306-022-01919-2

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Factors associated with TBS worse than BMD in non-osteoporotic elderly population: Bushehr elderly health program

BMC Geriatrics (2021)

Nekoo Panahi Afshin Ostovar Noushin Fahimfar Hamid Reza Aghaei Meybodi Safoora Gharibzadeh

Abstract Background Bone mineral density (BMD) and trabecular bone score (TBS) are moderately correlated. TBS is sometimes used as an adjuvant to BMD in the fracture risk assessment. Some individuals with normal BMD or osteopenia, have more degraded TBS. We aimed to identify factors associated with TBS worse than BMD in the non-osteoporotic elderly population. Methods The study subjects were selected from 2384 women and men aged ≥60 years participating in the second stage of the Bushehr Elderly Health program, a population-based prospective cohort study in Iran. The BMDs of different sites and the lumbar spine texture were measured using dual-energy X-ray absorptiometry and the TBS algorithm, respectively. Subjects were categorized based on their BMD and TBS status. Logistic regression was performed to identify the factors associated with “TBS worse than BMD” in non-osteoporotic individuals. Results Of 1335 participants included in the study, 112 of 457 women, and 54 of 878 men had worse TBS than BMD. In multivariable analysis, TBS worse than BMD in women was statistically significantly associated with years since menopause (OR: 1.04 (1.00–1.07)) and waist circumference (OR: 1.09 (1.05–1.14)). However, in men, the condition was statistically significantly associated with waist circumference (OR: 1.10 (1.03–1.17)), current smoking (OR: 2.54 (1.10–5.84)), and HDL-C (OR: 1.03 (1.00–1.06)). Conclusion The results of the study show that higher waist circumference is associated with more degraded TBS than BMD in both men and women. Years passed since menopause and current smoking, respectively in women and men, were associated with more degraded TBS. Considering TBS values in older individuals with higher waist circumference, or a history of smoking despite normal BMDs might help more accurate assessment of bone health. However, further studies are required to confirm the benefit.

Trabecular bone score

Osteopenia

10.1186/s12877-021-02375-8

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Incorporating NK Cells in a Three-Dimensional Organotypic Culture System for Human Skin Stem Cells: Modeling Skin Diseases and Immune Cell Interplay

Methods in molecular biology (2023)

Babak Arjmand Shayesteh Kokabi Hamidpour Akram Tayanloo-Beik Rasta Arjmand Mostafa Rezaei-Tavirani

Human skin

Cell type

10.1007/7651_2023_504

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Efficacy Evaluation of Treatment of Psoriasis Via Narrow Band-Ultraviolet Radiation

Journal of lasers in medical sciences (2024)

Mohammad Rostami‐Nejad Reza M. Robati Zahra Razzaghi Babak Arjmand Fatemeh Montazer

Introduction: Psoriasis is a common autoimmune skin disease associated with genetically influenced chronic inflammation accompanied by remitting and deteriorating scaly skin. T-cell targeted biologics, IL-17 inhibitors, IL-12/IL-23 inhibitors, TNF-α inhibitors, PDE4 inhibitors, and ultraviolet (UV) radiation are applied to treat psoriasis. Efficacy evaluation of narrow band UVB (NB-UVB) radiation was the aim of this study. Methods: Data were extracted from Gene Expression Omnibus (GEO) and were pre-evaluated via the GEO2R program. The significant differentially expressed genes (DEGs) were included in the protein-protein interaction (PPI) network analysis. The hubs, bottlenecks, and hub-bottleneck DEGs were introduced as central genes. Activation, inhibition, and expression relationship between central genes were assessed to explore the critical individuals. Results: Among 513 analyzed significant DEGs, 22 hub-bottleneck genes were identified. Further analysis revealed that FN1, STAT3, HIF1A, IL1B, P4HB, SOD2, MMP2, and STAT1 were the crucial genes in psoriasis samples targeted by NB-UVB radiation. Conclusion: In conclusion, NB-UVB radiation as a treatment targets critical genes in peri-lesion skin tissue biopsy of psoriasis patients via a complicated mechanism. This therapeutic method downregulates STAT3, HIF1A, IL1B, and P4HB to treat psoriasis but downregulates STAT1 and SOD2 and upregulates MMP2 and FN1 to develop disease.

STAT1

10.34172/jlms.2024.26

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Rat Bone Marrow Derived Mesenchymal Stem Cells (rBMMSCs) Encapsulated in Collagen Type I Containing Platelet-Rich Plasma for Osteoarthritis Treatment in Rat model

Research Square (Research Square) (2021)

Md Shahidul Islam Somayeh Ebrahimi‐Barough Mamun Al Mahtab Sadegh Shirian Hamid Reza Aghayan

Abstract The authors have requested that this preprint be removed from Research Square.

Type I collagen

10.21203/rs.3.rs-201503/v1

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Citations (1)