M. K. Santosh

Swami Ramanand Teerth Marathwada University

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D. Shaila

I. Sanjeeva Rao

I. Rajyalakshmi

Jawaharlal Nehru Technological University, Hyderabad

I. Sanjeevarao

T. Chandrakumar

Santosh Kamble

Swami Ramanand Teerth Marathwada University

Rahul D. Kamble

Abu Dhabi National Oil (United Arab Emirates)

Y. N. Seetharam

Indian Institute of Science Bangalore

G. Sharanabasappa

Gulbarga University

Bhagwat Poul

Swami Ramanand Teerth Marathwada University

Cooperative Institutions

Swami Ramanand Teerth Marathwada University

Gulbarga University

Abu Dhabi National Oil (United Arab Emirates)

Savitribai Phule Pune University

Sanjay Ghodawat University

Alwar Pharmacy College

Baker Hughes (United States)

Jawaharlal Nehru Technological University, Hyderabad

Wayne State University

Children's Hospital of Michigan

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Phytochemical Studies onBauhinia racemosaLam.Bauhinia purpureaLinn. andHardwickia binataRoxb

Journal of Chemistry (2006)

G. Sharanabasappa M. K. Santosh D. Shaila Y. N. Seetharam I. Sanjeevarao

The present paper deals with the phytochemical studies on Bauhinia racemosa Lam., Bauhinia purpurea Linn. and Hardwickia binata Roxb. The phytochemical study of three plants involve preliminary phytochemical studies, physico‐chemical studies, quantitative estimation of primary and secondary metabolites, TLC study and HPLC fingerprint study of ethanolic extract of leaves of three plants. In HPLC fingerprint study, the three peaks at a retention time of 15 min, 17 min and 19 min were identical in B. racemosa and B. purpurea which was confirmed by overlaid spectra. The generated data may be useful in suggesting chemotaxonomical interrelation between three plants.

Phytochemical

Bauhinia

10.1155/2007/874721

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Citations (38)

Physicochemical and Phytochemical Examination of Medicinal Plants Used in Indigenous System of Medicine

Journal of Chemistry (2005)

M. K. Santosh D. Shaila T. Chandrakumar I. Rajyalakshmi I. Sanjeeva Rao

The present paper deals with the physicochemical and phytochemical examination of seventy‐six medicinal plants belonging to thirty‐six dicot and six monocot families. These are used in indigenous system of medicine as well as local inhabitants either as single drugs or in combination, for the cure of various ailments. In physicochemical study, the parameters such as moisture content, p H (1% aqueous), total ash, acid insoluble ash, water‐soluble extractive and alcohol soluble extractive were carried out. The preliminary phytochemical study was done for the detection of secondary metabolites such as alkaloid, flavonoid, glycoside, phenol, saponin, resin, steroid and tannin. The preliminary phytochemical study revealed the presence of alkaloid and saponin in 68.4%; flavonoid in 44.7%; glycoside, phenol and steroid in 72.37%; resin in 60.5% and tannin in 71% of selected medicinal plants.

Phytochemical

Tannin

10.1155/2005/589869

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Citations (5)

Standardization Study of Antifertility Drug - Pippalyadiyoga

Journal of Chemistry (2005)

D. Shaila M. K. Santosh Biswajit Chowdhury I. Rajyalakshmi I. Sanjeevarao

The present paper deals with the standardization study of pippalyadiyoga powder. It is used as a long acting contraceptive. The standardization of compound drug has been achieved by physico‐chemical analysis and high performance liquid chromatography (HPLC) fingerprint studies. Quantitative evaluation of borax in pippalyadiyoga showed 19.08% as sodium borate. RP‐HPLC was performed using methanol and water as mobile phase. The detection and quantification was performed at a wavelength of 345 nm. Linearity of detector response for piperine was between the concentrations 0.005% to 0.1%. The correlation coefficient obtained for the linearity was 0.998. The recovery value of standard piperine was 99.4%. Low value of standard deviation and coefficient of variation are indicative of high precision of the method. Quantitative evaluation of piperine in pippalyadiyoga was found to be 0.339%.

Piperine

Coefficient of variation

Borax

10.1155/2005/346576

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Standardization Study of Ghritas

Journal of Chemistry (2004)

D. Shaila M. K. Santosh T. Chandrakumar I. Sanjeeva Rao

The standardization of ghritas such as amritaprasa ghrita, brahmi ghrita, chagalyadi ghrita and phala ghrita has been studied. These ghritas are the important Ayurvedic formulations used for peri‐natal care of mother and child health. Standardization of ghritas were achieved by organoleptic study, physico‐chemical analysis, qualitative analysis, thin layer chromatography (TLC), UV ‐ visible spectrophotometry and high performance liquid chromatographic (HPLC) fingerprint studies. Qualitative analysis of alcoholic extracts of all the four ghritas shows the presence of glycosides and hexane extracts shows the presence of glycosides and steroids. TLC study of ghritas was carried out in toulene‐ethyl acetate solvent system. Hexane extracts of ghritas were used for UV‐ visible spectrophotometry and qualitative HPLC fingerprint study.

Qualitative analysis

Spectrophotometry

Organoleptic

Ultraviolet visible spectroscopy

10.1155/2004/609058

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Citations (10)

Standardisation Study Standardisation Study of Kwatha Curnas f Kwatha Curnas

M. K. Santosh D. Shaila I. Sanjeeva Rao

The present paper deals with the standardization of kwatha curnas such as dhanyapanchak kwatha curna, guduchyadigana kwatha curna and stanyajanankashaya curna. These are the important Ayurvedic formulations used for peri-natal care of mother and child health. Standardization of kwatha curnas were achieved by physico-chemical analysis, qualitative inorganic and organic analysis, thin layer chromatography (TLC), UV- visible spectrophotometry and high performance liquid chromatographic (HPLC) fingerprint studies. TLC study of kwatha curnas was carried out in Ethyl acetate: Methanol: Water solvent system. Ethanol extracts of kwatha curnas were used for UV- visible spectrophotometry and qualitative HPLC fingerprint study.

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RP ‐ HPLC Method for Determination of Piperine from Piper longum Linn. and Piper nigrum Linn

Journal of Chemistry (2005)

M. K. Santosh D. Shaila I. Rajyalakshmi I. Sanjeeva Rao

Piper longum Linn. and Piper nigrum Linn. are used as spices and medicines. Quantitative determination of piperine was undertaken to provide an easy and simple analytical method, which can be used as a routine quality control method. RP‐HPLC was performed using methanol and water as mobile phase. The detection and quantification was performed at a wavelength of 345 nm. Linearity of detector response for piperine was between the concentrations 0.005% to 0.1%. The correlation coefficient obtained for the linearity was 0.998. The assay value of piperine for fruit and root of P. longum was found to be 0.879% and 0.31%. The assay value of piperine for fruit of P. nigrum was 4.5%. The recovery value of standard piperine was 99.4%. Low value of standard deviation and coefficient of variation are indicative of high precision of the method.

Piperine

10.1155/2005/627029

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Citations (28)

International Journal of Pharmaceutical Sciences and Research (2018)

Santosh Kamble Bhagwat Poul M. K. Santosh Rahul D. Kamble

Experiments were performed to design, develop and characterize bilayer buoyant tablets with Tramadol (TH), immediate release layer and Pregabalin (PGB), sustained release layer.Super disintegrants like crosscarmellose sodium and sodium starch glycolate, for IR layer where as Hydroxypropyl methylcellulose (HPMC-K4M, HPMC-K100M) and sodium carboxymethyl cellulose, as sustaining polymers for SR layer and sodium bicarbonate which liberates carbon dioxide for adequate buoyancy, was used in the bilayer tablet.FT-IR and DSC studies were conducted to evaluate drug and excipients compatibility.A full two level factorial experimental design was used for sustaining PGB release from buoyant SR layer.More than 90% of Tramadol was released from IR layer within 30 min.Diffusion exponents (0.36-0.55) and (T 50 %) time required for dissolving 50% of drug (1.96-3.31h)was determined for all SR tablet formulations.Optimised (S4) formulation exhibited 95.28% PGB released over 12 h.Since neuropathic pain is very difficult to treat, a delivery system for combination pharmacotherapy containing immediate releases of TH a unique powerful painkiller to provide instant pain relief and sustained release of PGB, the choice of drug in first-line treatment for various neuropathic pain syndromes can provide excellent therapeutic result by suppressing burning-fire pain stimulation of nerves with once a day administration. INTRODUCTION:Neuropathy a disease of nerve is the common cause of pain in modern world.Chronic neuropathic pain is the most disturbing symptom of lesions in the peripheral nervous system that can be of many forms.Peripheral neuropathy is often distressing, may produce disabilities or even found to be fatal.

10.13040/ijpsr.0975-8232.9(7).2832-41

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Citations (0)

Standardisation Study of Kwatha Curnas

Journal of Chemistry (2004)

M. K. Santosh D. Shaila I. Sanjeeva Rao

The present paper deals with the standardization of kwatha curnas such as dhanyapanchak kwatha curna, guduchyadigana kwatha curna and stanyajanankashaya curna. These are the important Ayurvedic formulations used for peri‐natal care of mother and child health. Standardization of kwatha curnas were achieved by physico‐chemical analysis, qualitative inorganic and organic analysis, thin layer chromatography (TLC), UV‐ visible spectrophotometry and high performance liquid chromatographic (HPLC) fingerprint studies. TLC study of kwatha curnas was carried out in Ethyl acetate: Methanol: Water solvent system. Ethanol extracts of kwatha curnas were used for UV‐ visible spectrophotometry and qualitative HPLC fingerprint study.

10.1155/2004/729261

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Citations (2)