Ficus deltoidea Jack of family Moraceae (FD) is a native shrub in Malaysia that are well known for its ethno-pharmaceutical and therapeutic properties. In this study, computational and experimental approaches were adopted to unravel the therapeutic properties of the FD leaf. Initially, quality control and safety assessment on the FD leaf were undertaken. The findings from this analysis revealed that the FD leaf of high quality, purity and abide by the safety requirements set by the regulatory body. FD leaf was solvent extracted as 50% (v/v) ethanol water extract. Standardization using high performance liquid chromatography (HPLC) revealed vitexin and isovitexin as the major chemical compounds in the FD leaf 50% (v/v) ethanol water extract. FD leaf 50% (v/v) ethanol water extract and its major chemical compounds (vitexin and isovitexin) were subjected to a selected panel of enzymatic inhibition assay, namely, α-amylase and matrix metalloproteinases (MMP-2, MMP-8 and MMP-9). The results showed that FD leaf 50% (v/v) ethanol water extract, vitexin and isovitexin exhibited inhibition property against the selected enzyme panels. Then, computational analyses (molecular docking and molecular dynamic simulation) revealed the molecular interaction and ligand-protein complex stability between vitexin and isovitexin against the selected enzyme panels. FD leaf 50% (v/v) ethanol water extract also showed antioxidant activity based on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and in vitro cytotoxicity based on 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay revealed the IC50 of the extract was at 221 μg/ml on EA.hy926 cells. FD leaf 50% (v/v) ethanol water extract also demonstrated cell migration inhibitory effect on EA.hy926 cells in a dose and time-dependent manner with the highest activity tested at 300 μg/ml after 24 hours treatment. The biological activity of FD leaf 50% (v/v) ethanol water extract was further studied using 2 types of in vivo animal models (healthy and streptozotocin-induced diabetic Sprague-Dawley rats). Toxicology analysis was conducted at 1000 mg/kg of FD leaf 50% (v/v) ethanol water extract. Visual inspection, blood analysis and histology analysis revealed no acute toxicity of the leaf extract at the tested concentration. Wound healing activity of FD leaf 50% (v/v) ethanol water extract was studied on both animal models. FD leaf 50% (v/v) ethanol water extract showed highest wound healing property at 100 mg/ml and the diabetic rat model showed faster wound closure rate compared to the healthy rat model. Finally, this study provided comprehensive and valuable information on the potential of FD leaf extract for therapeutic application especially for the wound healing in diabetic cases.
Objective: People with intellectual disability often have poor oral health, which can negatively impact their quality of life. It has been unclear which barriers that contributes to this, especially among institutionalized intellectual disability in Padang city. This qualitative study explores the underlying barriers to oral healthcare from the perspective of the caregivers as well as people who living with them. Material and Methods: Qualitative exploration was undertaken using in-depth interviews with caregivers in the public intellectual disability institution, Padang city. Data were collected from three caregivers. Thematic analysis identified key themes to explore in depth of the barrier oral healthcare among individuals with ID used N-vivo software. Results: Both individual and caregiver barriers to oral healthcare are offered to people with intellectual disability. These barriers include severity disorder, lack of focus and uncontrolled dietary intake. Caregivers lack knowledge and information regarding their rights to oral healthcare for individuals with special needs, the imbalance ratio caregiver and financial problem were also barriers. Conclusion: Individuals with ID face several barriers in maintain oral hygiene such as severity of disorder, the lack of attention, imbalance ratio of caregivers and children, dietary intake, oral health education of caregivers, and financial problems.
Pursuant to various fenomena which have been told above met some problema related to problem of poorness either through Strutural and cultural at rural society in Province. Riau. Among / Between problema emerge for example, about influence and Role of religion to ethos work and social aktifitas of rural society economics in Province. Riau. Following problem of Factor which is cause of poorness at rural society in Its Province. it him Solution in overcoming poorness at rural society in Province. Riau and also society attitude of pedaeanan to prosperity and its relation / link with economic activity and Cultural social by Rural Society specially in Province. Riau.
Brassica oleracea or cabbage is a very popular plant among Malaysians. This
project was carried out to determine the total phenolic content for cabbages in
the local market after extraction with two different solvents which are water
and ethanol. This project was carried out to obtain and differentiate the total
phenolic content between red cabbage and green cabbage. The total phenolic
content was determined using Folin-Ciocalteu reagent method based on the
standard calibration curve of Gallic acid measured at 650 nm using UV-Visible
Spectrometer (Perkin Elmer). The total phenolic content for red cabbage that
extracted with water was 0.0150 mg/g GAE whereas for green cabbage that
extracted with water was 0.0067 mg/g GAE. The total phenolic content for red
cabbage that extracted with ethanol was 0.0016 mg/g GAE whereas the total
phenolic content for green cabbage that extracted with ethanol was 0.0047
mg/g GAE. The research shown that the total phenolic content that soaked in
water for both kinds of cabbage have the higher total phenolic content.
This study aims to determine the effect of cash flow from operating activities and cash flows on investment activities on the profitability of the company in PT Multi Sukses. In this study the cash flow of operating activities is represented by the cash flow liquidity ratio, and the cash flow of investment activities is represented by the cash flow investment ratio. The researcher uses an associative approach, where the associative approach aims to determine the effect of operating cash flows and investment cash flows on the profitability of the company. Data collection is done by documentation and library engineering techniques. The results showed that the operating cash flow diproxy of cash flow liquidity ratios had a significant effect on the profitability of the company while the investment cash flow proxy from the cash flow investment ratio had no significant effect on the profitability of the company.
Micro-entrepreneurs in rural Indonesia often face challenges in accessing financial services and developing sustainable business practices. This community service initiative aimed to empower micro-entrepreneurs in Lubuk Beringin, Bungo Regency, Jambi, Indonesia, by promoting financial inclusion and rural development. A mixed-methods approach was employed, incorporating surveys, focus group discussions, and in-depth interviews to assess the needs and challenges of micro-entrepreneurs. Based on the findings, a comprehensive program was designed and implemented, encompassing financial literacy training, business development workshops, and access to microcredit facilities. The program resulted in increased financial literacy, improved business skills, and enhanced access to financial resources among the participants. Data indicates a 20% increase in average monthly income and a 15% rise in business savings among participating micro-entrepreneurs six months after program completion. Additionally, the program fostered a sense of community and collaboration among the participants. This initiative demonstrates the vital role of public administration in empowering micro-entrepreneurs through financial inclusion and rural development strategies. By providing access to financial knowledge, skills, and resources, public administration can contribute to sustainable economic growth and improved livelihoods in rural communities.
Various accountability issues concerning the Malaysian Federal Statutory Bodies (MFSB) have been revealed by various parties in their reports. Being a public sector body adopting a corporate-styled management and representing a substantial segment of the public sector, MFSB are expected to discharge its accountability and promote transparency. One aspect of accountability and transparency is the disclosure of accountability information (AI) in the annual report. In light of this, the study seeks to obtain insights on the extent of disclosure of AI in the annual reports of MFSB. Drawing from the public accountability paradigm and institutional theory, three objectives of the study are developed: (i) to determine the extent of disclosure of AI in MFSB annual reports, (ii) to examine whether certain set of variables, namely the type of MFSB, board size, board composition, existence of audit committee and fiscal stress have significant association with the extent of disclosure as found in (i), and (iii) to identify the reasons for disclosure (and nondisclosure) of AI in MFSB annual reports.
The study employs a mixed method research design. The data for quantitative phase was collected from 2008 annual reports of 106 MFSB using a disclosure index. They were then analysed using the General Linear Model (GLM) command for the multiple regression technique. Thereafter, 20 semi-structured interviews were conducted with 32 preparers and/or managers of MFSB and the meaning categorization approach was employed to analyse the data.
It was found that MFSB provided a moderate level of disclosure of 47.8 per cent in their annual report, ranging from 25 to 71 per cent. The results also showed that the most disclosed category was Performance, followed by the Overview, Financial, Others (i.e. human resource, socio-environmental and main assets), and Governance category. In addition, the study found that the strength of the regression model is moderate at an adjusted R2 of 0.409. Two out of five hypotheses are supported. It was established that there is a significant association between the extent of AI disclosure and the type of MFSB as well as a significant positive association between the extent of AI disclosure and the existence of an internal member on the board.
The interview revealed 53 and 58 reasons for disclosure and nondisclosure, respectively. Six themes emerged from both situations with three of them being similar, namely the nature of the data for reporting, implication of reporting, and traditions and practices in preparing reports. The themes unique in the case of disclosure are external influences, internal influences, and awareness. Among the common reasons for disclosure are to adapt the reporting practices of others and to enlighten stakeholders on MFSB functions and activities. On the other hand, the three unique themes for nondisclosure are demand of the information, resources, and preparers. The main reasons for nondisclosure is the lack of reporting benefit and insignificant data.
The study provides useful inputs for both practitioners and researchers which may subsequently help to improve the extent of disclosure of AI and eventually enhance accountability and transparency among public sector entities particularly MFSB.
Based on the consumer price index (CPI) issued by the Department of Statistics, prices of goods and services have generally increased by 29 percent in general over a period of 10 years, between 2005 and 2015. BR1M or 1Malaysia People’s Aid program is devised by the Malaysian Government as the effort to ease the burden of lower income group in Malaysia. The program is devised to help the lower income group cushion the high cost of living in Malaysia. Hence this research study the implementation of BR1M by conducting an exploratory case study in a rural district in Kedah to gain input on the level of satisfaction and the self-sufficiency of the of BR1M recipient. Findings show that BR1M needs continuous improvement and revisiting the plan.
Little is done on the empirical analyses of the impact of defence expenditure on arms and economic growth. The few conducted concentrated on developed countries, which are exporters of arms. This study examines the short run and long run impact of arms importation on the economic growth in Nigeria, using ARDL model. Literature on defence expenditure and economic growth are often conflicting and inconclusive. These outcomes are due to the non-linear growth effects of defence and incorrect model specifications. The crucial growth effects of defence expenditure can be traced by properly controlling the interaction term. This paper examines the defence-arms interaction on Nigeria in the context of Aizeiman and Glick (2006) models. The result reveals that defence-arms interaction in Nigeria exerts negatively on the economic growth. It therefore recommends that defence RD Arms Importation; Economic growth. JEL Classifications: H5, H56, H57, Q36
Tulisan ini bertujuan untuk menganalisa kebijakan pendidikan pada lembaga pendidikan Islam di Sudan. Negara ini mengalami konflik dan krisis yang berdampak pada berbagai aspek kehidupan masyarakatnya terutama aspek pendidikan yang telah menghambat pendidikan bagi sebagian besar anak-anak. Metode penelitian ini adalah studi kepustakaan (library research) dengan mengumpulkan data dari buku dan artikel yang terkakit dengan menggunakan metode analisis yaitu analisis deskriptif. Hasil dari penelitian ini terlihat bahwa pendidikan di Sudan digratiskan dan diwajibkan bagi seluruh anak-anak yang berusia dari 6 tahun hingga 13 tahun. Pada bidang pendidikan formal, Sudan memeliki beberapa universitas terkemuka yang telah berusia puluhan tahun bahkan ratusan tahun. Kemudian Bidang Pendidikan non-formal terdapat beberapa majelis ilmu yang menerapkan sistem talaqqi melalui para Masyaikh. Untuk pembiyaan pendidikan di samping di peroleh dari uang Negara juga di peroleh dari kebijakan system Wakaf dengan manajemen wakaf bernama Badan Wakaf Islam telah diberi wewenang yang luas dalam mengatur dan melaksanakan semua tugas yang berhubungan dengan wakaf yang sangat membantu pelaksanaan pendidikan yang ada di negara ini.