J. Peng

Sun Yat-sen University

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O. Ganry

Centre Hospitalier Universitaire Amiens-Picardie

Zhongxue Wu

Capital Medical University

Shiqing Mu

Hebei Medical University

Keqin Luo

Sun Yat-sen University

Jie Zhu

Xiamen University

C. Baudoin

Louisiana Cancer Research Center

Shi Yi-ni

Peking University

Menglei Yu

Sun Yat-sen University

Yi Cao

Nanchang University

A. Dubreuil

Association Française pour le Dépistage et la Prévention des Handicaps de l’Enfant

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Sun Yat-sen University

Inserm

Centre Hospitalier Universitaire Amiens-Picardie

Registre général des cancers de Lille et de sa région

Capital Medical University

Beijing Institute of Neurosurgery

Beijing Tian Tan Hospital

Université de Picardie Jules Verne

National Clinical Research Center for Digestive Diseases

Capital University

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The Influence of g.19124G>A Genetic Polymorphism in the OPG Gene on Bone Mineral Density in Chinese Women

Genetic Testing and Molecular Biomarkers (2013)

Jie Zhu Zitong Luo Yi Cao Menglei Yu J. Peng

The aim of this study was to detect the influence of g.19124G>A genetic polymorphism in the osteoprotegerin (OPG) gene on bone mineral density (BMD) and osteoporosis in Chinese postmenopausal women.A total of 403 primary osteoporosis subjects and 409 healthy controls were enrolled in this study. The BMD value of the femoral neck hip, lumbar spine (L(2-4)), and total hip was analyzed by Norland XR-46 dual energy X-ray absorptiometry. The polymerase chain reaction-restriction fragment length polymorphism method was utilized to investigate the genotype of g.19124G>A genetic polymorphism.We found significant differences of the femoral neck hip, lumbar spine (L(2-4)), and total hip of BMD among different genotypes of g.19124G>A genetic polymorphism, individuals with the genotype GG had significantly higher BMD than those of genotype GA and AA (p<0.05).These findings indicate that the g.19124G>A genetic polymorphism in the OPG gene is potentially related to BMD and osteoporosis in Chinese postmenopausal women, and the allele A could be associated with a lower BMD and an increased risk factor for osteoporosis.

Gene polymorphism

10.1089/gtmb.2013.0183

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Citations (2)

Is there a reduced risk of breast cancer among women with hip fractures?

European Journal of Epidemiology (1999)

O. Ganry J. Peng A. Dubreuil

Hip Fracture

10.1023/a:1007579112855

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Polymorphisms in DNA Repair Genes and Risk of Glioma and Meningioma

Asian Pacific Journal of Cancer Prevention (2013)

Keqin Luo Shiqing Mu Zhongxue Wu Shi Yi-ni J. Peng

Polymorphisms in DNA repair genes have been shown to influence DNA repair processes and to modify cancer susceptibility. Here we conducted a case-control study to assess the role of potential SNPs of DNA repair genes on the risk of glioma and meningioma. We included 297 cases and 458 cancer-free controls. Genotyping of XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC2 Arg188His, XRCC3 Thr241Met, XRCC4 Ala247Ser, ERCC1 Asn118Asp, ERCC2 Lys751Gln and ERCC5 Asp1558His were performed in a 384-well plate format on the Sequenom MassARRAY platform. XRCC1 Arg194Trp (rs1799782) and ERCC2 Asp312Asn rs1799793 did not follow the HWE in control group, and genotype distributions of XRCC1 Gln399Arg rs25487, XRCC2 Arg188His rs3218536 and ERCC2 Asp312Asn rs1799793 were significantly different between cases and controls (P<0.05). We found XRCC1 399G/G, XRCC1 194 T/T and XRCC3 241T/T were associated with a higher risk when compared with the wild-type genotype. For ERCC5 Asp1558His, we found G/G genotype was associated with elevated susceptibility. In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas. This finding could be useful in identifying the susceptibility genes for these cancers.

XRCC1

XRCC3

ERCC2

ERCC1

10.7314/apjcp.2013.14.1.449

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Citations (53)

Bone Mass Density and Risk of Breast Cancer and Survival in Older Women

European Journal of Epidemiology (2003)

O. Ganry C. Baudoin Patrice Fardellone J. Peng N Raverdy

10.1023/b:ejep.0000036567.60387.39

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Citations (41)