Sangtae Han

Kyungpook National University

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Hae‐Chul Park

Korea University

Cheol‐Hee Kim

Chungnam National University

Sung-Kook Hong

Kyungpook National University

Seok-Hyung Kim

Wonkwang University

Myungchull Rhee

Chungnam National University

Tae-Lin Huh

Kyungpook National University

Hyung-Seok Kim

Chonnam National University

Sang-Yeob Yeo

Hanbat National University

Jimann Shin

Washington University in St. Louis

Ajay Chitnis

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Cooperative Institutions

Kyungpook National University

Chungnam National University

Harvard University

Animal and Plant Quarantine Agency

Pusan National University

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Howard Hughes Medical Institute

Korea University

Korea University Medical Center

Hanyang University

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Characterization and expression of a presomitic mesoderm-specific mespo gene in zebrafish

Development Genes and Evolution (2003)

Kyeong-Won Yoo Cheol‐Hee Kim Hae‐Chul Park Seok-Hyung Kim Hyung-Seok Kim

Epiboly

Paraxial mesoderm

Blastoderm

Intermediate mesoderm

Somitogenesis

10.1007/s00427-003-0312-1

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Citations (17)

Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish

Development (2002)

Seok-Hyung Kim Jimann Shin Hae‐Chul Park Sang-Yeob Yeo Sung-Kook Hong

Wnts have been shown to provide a posteriorizing signal that has to be repressed in the anterior neuroectoderm for normal anteroposterior (AP) patterning. We have previously identified a zebrafish frizzled8a (fz8a) gene expressed in the presumptive anterior neuroectoderm as well as prechordal plate at the late gastrula stage. We have investigated the role of Fz8a-mediated Wnt8b signalling in anterior brain patterning in zebrafish. We show that in zebrafish embryos: (1) Wnt signalling has at least two different stage-specific posteriorizing activities in the anterior neuroectoderm, one before mid-gastrulation and the other at late gastrulation; (2) Fz8a plays an important role in mediating anterior brain patterning; (3) Wnt8b and Fz8a can functionally interact to transmit posteriorizing signals that determine the fate of the posterior diencephalon and midbrain in late gastrula embryos; and (4) Wnt8b can suppress fz8a expression in the anterior neuroectoderm and potentially affect the level and/or range of Wnt signalling. In conclusion, we suggest that a gradient of Fz8a-mediated Wnt8b signalling may play crucial role in patterning the posterior diencephalon and midbrain regions in the late gastrula.

Neuroectoderm

Diencephalon

10.1242/dev.129.19.4443

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Citations (91)