Carolina Hernández-Oliver

Spanish National Cancer Research Centre

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Manuel Valiente

Spanish National Cancer Research Centre

Neibla Priego

Centro de Investigación del Cáncer

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Laura Álvaro‐Espinosa

Spanish National Cancer Research Centre

Marc Schmitz

TU Dresden

Stephen J. Crocker

University of Connecticut

Asís Palazón

CIC bioGUNE

Fátima Al‐Shahrour

Spanish National Cancer Research Centre

Rebeca Sanz‐Pamplona

Institut d'Investigació Biomédica de Bellvitge

Diego Serrano

Universidad de Navarra

María Perea-García

Spanish National Cancer Research Centre

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Spanish National Cancer Research Centre

Centro de Investigación del Cáncer

Instituto de Salud Carlos III

Hospital Universitario 12 De Octubre

Universidad Complutense de Madrid

Research Institute Hospital 12 de Octubre

Centro de Investigación Biomédica en Red

Centro de Investigación Biomédica en Red de Cáncer

Universitat de València

Consejo Superior de Investigaciones Científicas

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Table S20 from TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells

Neibla Priego Ana de Pablos-Aragoneses María Perea-García Valentina Pieri Carolina Hernández-Oliver

Statistics of multiple experimental arms from in vivo immunotherapy experiments. Unpaired two-tailed Student’s t-test of different comparisons between the following experimental conditions: IgG2, silibinin and immune checkpoint blockade (ICB) (Anti-PD1 plus Anti-CTLA4) alone or in combination with silibinin in mice intracardially injected with B16/F10-BrM cells. Unpaired two-tailed Student’s t-test of different comparisons between the following experimental conditions: IgG2, cKOGFAP-Timp1 and immune checkpoint blockade (ICB) (Anti-PD1 plus Anti-CTLA4) alone or in combination in mice intracardially injected with E0771-BrM cells. The table contains information corresponding to Figure 7C and Supplementary Figure 8L.

Immunosuppression

10.1158/2159-8290.28193835

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Table S21 from TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells

Neibla Priego Ana de Pablos-Aragoneses María Perea-García Valentina Pieri Carolina Hernández-Oliver

TIMP1 levels from ELISA applied to CSF from patient samples. Levels of TIMP1 in the blood or in the cerebrospinal fluid (CSF) of non-cancer patients and brain metastasis patients from different primary tumors. Immune Cluster is shown for patients in Figure 7N. The table contains information corresponding to Figure 7L, 7N and Supplementary Figure 9A,C-D.

Immunosuppression

Table (database)

10.1158/2159-8290.28193832

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Table S11 from TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells

Neibla Priego Ana de Pablos-Aragoneses María Perea-García Valentina Pieri Carolina Hernández-Oliver

GSEA of CD8+ T cells incubated with pSTAT3+ conditioned media. Gene set enrichment analysis (GSEA) of top 25 upregulated and downregulated signatures and NES of Biological Process (GOBP) pathways related to T cell function comparing CD8+ in vitro cultures incubated with the pSTAT3- (d1) or pSTAT3+ (d2) secretome. The table contains information corresponding to Figure 2B.

Immunosuppression

Table (database)

10.1158/2159-8290.28193865

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Table S12 from TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells

Neibla Priego Ana de Pablos-Aragoneses María Perea-García Valentina Pieri Carolina Hernández-Oliver

RENACER immune cluster evaluation. Immune cluster and gene expression of immune markers in the RENACER cohort of human brain metastasis samples. The table contains information corresponding to Supplementary Figure 4C-D.

Immunosuppression

10.1158/2159-8290.28193862

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Metabolic Alterations in a Drosophila Model of Parkinson’s Disease Based on DJ-1 Deficiency

Cells (2022)

Cristina Solana‐Manrique F. Sanz Isabel Torregrosa Martina Palomino‐Schätzlein Carolina Hernández-Oliver

Parkinson’s disease (PD) is the second-most common neurodegenerative disorder, whose physiopathology is still unclear. Moreover, there is an urgent need to discover new biomarkers and therapeutic targets to facilitate its diagnosis and treatment. Previous studies performed in PD models and samples from PD patients already demonstrated that metabolic alterations are associated with this disease. In this context, the aim of this study is to provide a better understanding of metabolic disturbances underlying PD pathogenesis. To achieve this goal, we used a Drosophila PD model based on inactivation of the DJ-1β gene (ortholog of human DJ-1). Metabolomic analyses were performed in 1-day-old and 15-day-old DJ-1β mutants and control flies using 1H nuclear magnetic resonance spectroscopy, combined with expression and enzymatic activity assays of proteins implicated in altered pathways. Our results showed that the PD model flies exhibited protein metabolism alterations, a shift fromthe tricarboxylic acid cycle to glycolytic pathway to obtain ATP, together with an increase in the expression of some urea cycle enzymes. Thus, these metabolic changes could contribute to PD pathogenesis and might constitute possible therapeutic targets and/or biomarkers for this disease.

Pathogenesis

Metabolic pathway

10.3390/cells11030331

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Figure S7 from TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells

Neibla Priego Ana de Pablos-Aragoneses María Perea-García Valentina Pieri Carolina Hernández-Oliver

TIMP1 binding to CD63 modulates kinase signaling in CD8+ T cells. Supplementary Figure 7 shows additional data corresponding to Figure 6.

Immunosuppression

10.1158/2159-8290.28193883

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Table S6 from TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells

Neibla Priego Ana de Pablos-Aragoneses María Perea-García Valentina Pieri Carolina Hernández-Oliver

Human brain metastasis samples analyzed with Chromium Fixed RNA Profiling. Clinical information of human brain metastasis samples included in Figure 1F-I.

Immunosuppression

Human brain

10.1158/2159-8290.28193808

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Metabolic alterations in a Drosophila model of Parkinson’s disease based on DJ-1 deficiency

bioRxiv (Cold Spring Harbor Laboratory) (2021)

Cristina Solana‐Manrique F. Sanz Isabel Torregrosa Martina Palomino‐Schätzlein Carolina Hernández-Oliver

ABSTRACT Parkinson’s disease (PD) is the second most common neurodegenerative disorder whose physiopathology is still unclear. Besides, it is urgent to discover new biomarkers and therapeutic targets to facilitate its diagnosis and treatment. Previous studies performed in PD models and samples from PD patients already demonstrated that metabolic alterations were associated with this disease. In this context, the aim of this study is to give a better understanding of metabolic disturbances underlying PD pathogenesis. To achieve this goal, we used a Drosophila PD model based on inactivation of the DJ-1β gene (ortholog of human DJ-1 ). Metabolomic analyses were performed in 1-day-old and 15-day-old DJ-1β mutants and control flies using 1 H nuclear magnetic resonance spectroscopy, combined with expression and enzymatic activity assays of proteins implicated in altered pathways. Our results showed that PD model flies exhibit protein metabolism alterations, a shift from tricarboxylic acid cycle to glycolytic pathway to obtain ATP, together with an increase in the expression of some urea cycle enzymes. Thus, these metabolic changes could be contributing to PD pathogenesis and might constitute possible therapeutic targets and/or biomarkers for this disease.

Pathogenesis

Metabolic pathway

10.1101/2021.12.15.472768

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Table S4 from TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells

Neibla Priego Ana de Pablos-Aragoneses María Perea-García Valentina Pieri Carolina Hernández-Oliver

GSEA cluster 3, cluster 6 and cluster 7 of brain metastasis-associated astrocytes. Gene set enrichment analysis (GSEA) of top 25 upregulated and downregulated signatures comparing cluster number 3/6/7 of brain metastasis associated-astrocytes with the tumor free condition. The table contains information corresponding to Figure 1D-E and Supplementary Figure 1G-H.

Immunosuppression

Table (database)

10.1158/2159-8290.28193814

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Table S23 from TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells

Neibla Priego Ana de Pablos-Aragoneses María Perea-García Valentina Pieri Carolina Hernández-Oliver

Antibodies used for immunohistochemistry. Detailed information of antibodies used for immunohistochemistry stainings.

Immunosuppression

10.1158/2159-8290.28193826

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