Banu Doğan Gün

Bülent Ecevit University

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ŞO

Şükrü Oğuz Özdamar

Bülent Ecevit University

Figen Barut

Bülent Ecevit University

Nilüfer Onak Kandemir

Bilkent University

Burak Bahadır

Bülent Ecevit University

Sibel Bektaş

Gaziosmanpaşa Taksim Eğitim ve Araştırma Hastanesi

Gamze Yurdakan

Bülent Ecevit University

Aykut Barut

Bülent Ecevit University

Mustafa Cömert

Bülent Ecevit University

Mustafa Gün

Sivas Cumhuriyet Üniversitesi

Erol Aktunç

Bülent Ecevit University

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Bülent Ecevit University

139

Sağlık Bilimleri Üniversitesi

Gazi University

Inserm

University of Turin

Universidade Federal de São Paulo

Universidade de São Paulo

Istituti di Ricovero e Cura a Carattere Scientifico

Weatherford College

Ankara University

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Unilateral ovarian agenesis and clear cell type epithelioid leiomyoma of uterus mimicking ovarian malignancy.

PubMed (2014)

Ülkü Bayar Banu Doğan Gün Burcu Ungan Suat Doğan Aykut Barut

A case of unilateral absent ovary together with clear cell type epithelioid leiomyoma of uterus mimicking ovarian malignancy discovered during laparotomy is presented. Unilateral absence of an ovary is an extremely rare finding. Although the exact pathophysiological mechanism is not known, it could result from a defect in embryological development or asymptomatic torsion of ovary. Clear cell type epithelioid leiomyoma of uterus is also a rare variant, composed of round or polygonal 'clear' cells rather than typical spindle-shaped cells and ultra structurally differs from non-uterine counterparts.

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Schwannoma'larda farkli morfolojik ve immun dokukimyasal özellikler ile osseöz metaplazi gösteren bir olgunun sunumu

Türkiye Ekopatoloji Dergisi (2006)

Sibel Bektaş Büşra BAHADIR Sacide Çolak Banu Doğan Gün Burak Açıkgöz

Amac: Elli yasindaki erkek hastanin schwannoma tanisi alan spinal kitlesinin kesitlerinde fokal osseoz metaplazi saptanmasi uzerine, schwannoma olgularimizin histomorfolojik ve immundokukimyasal ozelliklerinin retrospektif olarak incelenmesi amaclanmistir. Yontem: 2002-2005 yillari arasinda Karaelmas of schwannoma retrospectively Universitesi Tip Fakultesi Patoloji Anabilim Dali’nda tani almis dokuz schwannoma olgusunun preparatlari Methods

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Experimental Obstructive Jaundice Results in Oxidized Low-Density-Lipoprotein Accumulation in Surgical Wound of Rats

Acta Chirurgica Belgica (2008)

Karadeniz Çakmak Öge Taşçılar İshak Özel Tekin Bülent Hamdi Uçan Arif Emre

Introduction : Mounting evidence suggests that impaired wound healing is a well-defined consequence in obstructive jaundice and, as redox-regulated processes are relevant to wound healing, it is not unreasonable to suppose that oxidative stress associated with lipid peroxidation in cholestasis might be a systemic phenomenon probably comprising all tissues and organs, including wounds. The aim of the present investigation was to analyse the lipid peroxidation status of surgical wounds, in terms of oxidized low-density-lipoprotein (oxLDL) accumulation in experimental obstructive jaundice.Methods : Sixteen Wistar-Albino rats weighing 200–230 gr were randomly divided into two groups. Group I (n = 8) was designed as the prolonged obstructive jaundice group and was subjected to bile duct ligation. Group II (Sham-control, n = 8) rats underwent laparotomy alone and bile duct was just dissected from the surrounding tissue. Histopathological evaluation, immunohistochemical screening and immunoflourescent staining of the surgical wound was conducted to the bile-duct ligated rats and control group on the 21st postoperative day.Results : Wound healing was found to be impaired in jaundiced rats histopathologically. When compared with the control group, significant positive oxLDL staining and intracellular accumulation of TNF-a, IL-2 and iL-6 was detected in the wound sections of the prolonged obstructive jaundice group.Conclusion : Our present data is the first in the literature, indicating significant oxLDL accumulation in surgical wounds of cholestatic rats, which might be one of the results of systemic oxidative stress leading to deficient healing capacity as a consequence of persistent inflammation.

Obstructive jaundice

10.1080/00015458.2008.11680324

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The effect of atorvastatin and its role on systemic cytokine network in treatment of acute experimental colitis

Immunopharmacology and Immunotoxicology (2011)

Erol Aktunç Başak Kayhan Mehmet Araslı Banu Doğan Gün Figen Barut

Inflammatory bowel diseases are characterized by disabilities in gastrointestinal system and defects in mucosal immune system. Statins are 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitor and are used to treat hypercholesterolemia in patients with coronary artery and atherosclerotic diseases. Recent studies have demonstrated that statins have immunomodulatory role by effecting different pathways in immune system. In this study, we investigated the effect of atorvastatin and its mechanism on systemic immune response in treatment of trinitrobenzene sulfonic acid (TNBS)-induced colitis mice. We observed that atorvastatin significantly suppressed the severity of TNBS-induced colitis in BALB/c mice. This was manifested in reduced rectal bleeding, decrease in colon length, reduction of histological damage, and improved survival. Concurrently, we investigated the immunomodulatory role of atorvastatin on systemic immune system. We investigated the proinflammatory (IL-1α, IL-6, TNF-α), Th1 (IFN-γ, IL-2), Th2 (IL-4, IL-5, IL-10), and Th17 (IL-17, IL-23) cytokine levels in serum samples of colitis and atorvastatin-administered mice. We discovered that administration of atorvastatin significantly down-regulates systemic TNF-α level and Th17 cytokine levels. Furthermore, atorvastatin treatment switches Th1 type T-cell response toward/to Th2 (IL-4, IL-10) type response.

Proinflammatory cytokine

10.3109/08923973.2011.559475

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Reproducibility of Fuhrman Nuclear Grading of Renal Cell Carcinoma: A Preliminary Study

TURKISH JOURNAL OF MEDICAL SCIENCES (2009)

Sibel Bektaş Figen Barut Burak Bahadır Banu Doğan Gün Nilüfer Onak Kandemir

Background: The aim of this study was to evaluate intraobserver and interobserver reproducibility of Fuhrman nuclear grading of renal cell carcinoma. Methods: Pathology slides from 46 cases of renal cell carcinoma were rescored by 2 pathologists according to the Fuhrman system. Both intraobserver and interobserver reproducibility were assessed using kappa statistics. Results: The initial Fuhrman grade was grade 1 in 4 of the cases (8.7%), grade 2 in 30 (65.2%), grade 3 in 11 (23.9%), and grade 4 in 1 (2.2%). After reviewing the slides by the same pathologist, grades were reassigned as follows: grade 1 in 8 cases (17.4%), grade 2 in 23 (50%), grade 3 in 14 (30.4%), and grade 4 in 1 (2.2%). Intraobserver reproducibility of the Fuhrman system was substantial (\kappa = 0.66). Fuhrman grading by the second pathologist was grade 1 in 11 cases (23.9%), grade 2 in 27 (58.7%), grade 3 in 7 (15.2%), and grade 4 in 1 (2.2%). Interobserver reproducibility of the Fuhrman system was moderate (\kappa = 0.42). Conclusions: Despite substantial intraobserver reproducibility of Fuhrman grading, moderate interobserver reproducibility and low agreement for grade 3 should be a consideration.

Grading (engineering)

Kappa

10.3906/sag-0803-4

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The relation between gleason score, and nuclear size and shape factors in prostatic adenocarcinoma

TURKISH JOURNAL OF MEDICAL SCIENCES (2009)

Sibel Bektaş Burak Bahadır Banu Doğan Gün Gürkan Kertiş Şükrü Oğuz Özdamar

Aim: The aim of this study was to assess the size and shape characteristics of prostatic adenocarcinoma cell nuclei using a computer-assisted analysis system, and to compare the results with the Gleason score. Materials and Methods: Morphometric nuclear parameters, such as roundness factor, form ellipse, area, length, and perimeter, were evaluated based on specimen slides of 130 prostatic adenocarcinoma cases (77% needle biopsies and 23% prostatectomy specimens) using a computerized image analysis system. Correlation analysis between Gleason score and morphometric results was performed. Results: The Gleason score was correlated with mean nuclear area (r = 0.516, P = 0.01), mean nuclear length (r = 0.298, P = 0.01), and mean nuclear perimeter (r = 0.303, P = 0.01) for all specimens. In the needle biopsy group the Gleason score was correlated with mean nuclear area (r = 0.522, P = 0.01), mean nuclear length (r = 0.398, P = 0.01), and mean nuclear perimeter (r = 0.432, P = 0.01), whereas in the prostatectomy group the Gleason score was correlated only with mean nuclear area (\sigma = 0.619, P = 0.01) and mean nuclear roundness factor (\sigma = -0.425, P = 0.05). Conclusions: Nuclear size and shape factors, especially mean nuclear area, were concordant with the Gleason score. Nuclear size and shape assessment may aid in the evaluation of the pathological status of prostatic adenocarcinoma.

Perimeter

Prostatic adenocarcinoma

Nomogram

Roundness (object)

10.3906/sag-0711-31

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Citations (16)

Safra kesesinde metaplazi, displazi ve karsinom dizgesi

Akademik Gastroenteroloji Dergisi (2007)

Burak Bahadır Banu Doğan Gün Sacide Çolak Gürkan Kertiş Mustafa Cömert

Metaplastic changes in the gallbladder commonly associated with cholelithiasis and chronic inflammation may represent premalignant lesions in the course of malignant transformation. Moreover, existence of a probable metaplasia-dysplasia-carcinoma sequence may bear importance in developing gallbladder carcinomas. Materials and methods: In this study, 351 cholecystectomy specimens of 121 male and 230 female patients with chronic cholecystitis seen from May 2001 to November 2006 in Karaelmas University Faculty of Medicine were re-evaluated in terms of metaplasia, dysplasia, carcinoma in situ and carcinoma. Results: While pure antral-type metaplasia was the most common metaplasia (81 cases), intestinal metaplasia was detected in 18 cases. Eight cases displayed coexistence of antral and intestinal metaplasia. Varying degrees of dysplasia were revealed in 3 cases with antral metaplasia, in 11 cases with intestinal metaplasia and in 3 cases with both antral and intestinal metaplasia. Incidental carcinoma was determined in 4 of the 11 cases with intestinal metaplasia and dysplasia. Conclusions: The occurrence of metaplasia, perceived as 30% in the current study, points out that chronic tissue injury secondary to cholelithiasis and chronic inflammation is the major factor contributing to developing metaplasia. In addition to the possibility of intestinal metaplasia developing from antral metaplasia, progressing to carcinoma by causing dysplasia, the high incidence of metaplasia in both carcinomatous components and surrounding mucosa supports the idea that this spectrum of changes may play a role in the development of gallbladder cancer.

Intestinal metaplasia

Metaplasia

10.17941/agd.95656

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Citations (1)

Front & Back Matter

Gynecologic and Obstetric Investigation (2012)

Yoichiro Akahori Hisashi Masuyama Yuji Hiramatsu G. Migliaretti Francesco Deltetto

10.1159/000337917

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Salivary Gland Myoepithelioma with Focal Capsular Invasion

Ear Nose & Throat Journal (2009)

Banu Doğan Gün Şükrü Oğuz Özdamar Burak Bahadır Lokman Uzun

Salivary gland tumors that display myoepithelial differentiation exclusively or predominantly are relatively uncommon, and the assessment of malignancy in a myoepithelial tumor can be difficult. We report a case of parotid gland myoepithelioma composed predominantly of spindle cells with focal capsular invasion. The patient was a 65-year-old woman who presented with a painless mass in the right preauricular region. Histologically, the tumor had a solid and multinodular growth pattern and was predominantly made up of spindle cells with a minor component of epithelioid cells with moderate cellular atypia. Focal regions of tumor cells infiltrated the capsule with tongue-like processes, but tumor infiltration into the adjacent parotid tissue was absent. The tumor cells showed strong cytoplasmic immunoexpression of vimentin, pankeratin, S-100 protein, and smooth-muscle actin. Immunostains with glial fibrillary acidic protein, melanoma marker, epithelial membrane antigen, and carcinoembryonic antigen were negative. Expression of p53 was observed focally in the nuclei of the tumor cells. A final diagnosis of salivary gland myoepithelioma with focal capsular invasion was made, and the case was regarded as a myoepithelial tumor of uncertain malignant potential. In this report, we discuss the histologic criteria required to diagnose malignancy in salivary gland myoepithelial tumors.

Myoepithelioma

10.1177/014556130908800710

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Reasons for false-negative and false-positive diagnosis in fine needle aspiration cytology of the breast: 286 cases with cyto-histopathologic correlation

Turkish Journal of Pathology (2010)

Nilüfer Onak Kandemir Sibel Bektaş Figen Barut Gamze Yurdakan Burak Bahadır

Objective: The objectives were to evaluate fine needle aspiration cytology results of 39 pediatric patients, and the pathologies that cause childhood thyroid nodules, and to review the literature on the subject. Material and Method:Thyroid fine needle aspiration cytology results of 39 pediatric patients were retrospectively reviewed.Associated diseases, thyroid functions, anti-thyroid antibody levels, ultrasonographic findings and number of nodules were also evaluated. Results:The vast majority of patients with thyroid nodules were cytopathologically diagnosed as benign (97.3%).Of these patients, 64.8% (24 patients) were diagnosed as nodular goiter and 35.2% (13 patients) as lymphocytic thyroiditis.Thyroid malignancy was found in two patients; one was diagnosed as follicular neoplasm/ minimal invasive follicular carcinoma on surgical evaluation while the other was a secondary tumor (Burkitt's lymphoma).The majority of our subjects were females (66.6%): the female/male ratio was 2:1 for nodular goiter and 3.3:1 for thyroiditis.Surgical resection was performed in 5 patients (4 cases of nodular goiter, 1 suspicious for malignancy) and cytological diagnoses were confirmed by histology. Conclusion:Our study confirmed the utility of fine needle aspiration cytology in childhood thyroid disorders along with a possible higher incidence of nodular thyroiditis in childhood.Nodular autoimmune thyroiditis, focal thyroiditis and thyroid cancer in children are discussed and attention is drawn to some special subtypes of thyroid cancer and some benign lesions that can cause difficulty in interpreting fine needle aspiration cytology and frozen sections at this age.

Thyroid Nodules

Thyroid lymphoma

10.5146/tjpath.2010.01029

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