Objectives: This study aims to find the correlation between anti mullerian hormone (AMH) and follicle stimulating hormone (FSH) and to observe the above mentioned hormones' relation with antral follicle count (AFC) in patients with primary infertility.Methodology: This is a cross-sectional correlation study in which 60 patients with primary infertility meeting inclusion criteria, attending infertility clinic in ESIC MC PGIMSR, Rajajinagar between January 2017 and June 2018 were enrolled by simple random sampling.Detailed menstrual, obstetric, coital and medical history was obtained.On the third day of the spontaneous cycle, all patients were investigated with a transvaginal scan to assess the number of antral follicles and a fasting venous blood sample was obtained for the measurement of serum AMH and serum basal FSH level.Results: Basal serum FSH shows a moderately strong negative correlation with antral follicle count (AFC) (r=0.65;p=<0.001); and a strong negative correlation with anti mullerian hormone (AMH) (r=0.69 and p=<0.001).However, the strongest correlation between a biochemical marker and biophysical marker of ovarian reserve is between anti mullerian hormone (AMH) and antral follicle count (AFC) with a very strong positive correlation with a correlation co-efficient r=0.89 (p=<0.001).Conclusion: Serum AMH best correlates with the antral follicle count.Antral follicle counts although an efficient test to detect ovarian reserve is uncomfortable for the patient as it has to be done during menstrual flow.Serum AMH with minimal intracycle and intercycle variation is a more convenient marker to assess ovarian reserve while it maintains the accuracy of AFC.
Background: Interpregnancy interval (IPI) or birth to pregnancy interval is defined as time interval between live birth and beginning of following pregnancy.Interpregnancy interval has been shown to be an important prognostic marker for perinatal outcome.According to WHO atleast 24 months of interpregnancy interval is optimal.Objective: This study was planned to correlate maternal and perinatal outcome with interpregnancy interval at a tertiary care centre in northern India.Materials and methods: The study was a cross sectional observational study.It was conducted in department of obstetrics and gynecology, KGMU Lucknow.All pregnant women beyond period of viability, delivering at our centre, irrespective of live or stillborn were included in the study.Maternal and perinatal outcome of all the patients was observed.Results: 212 women were assessed in terms of interpregnancy interval and its correlation with maternal and perinatal outcome.Of these 212 women interval less than or equal to 24 months, 125 had interpregnancy interval >24 months.Proper antenatal registration (4 visits atleast) was more in IPI more than 24 months group.Severe anemia and non severe preeclampsia was found to be more in group with IPI ≤24 months than group IPI> 24 months.Perinatal outcome was found to be far better in group IPI> 24 months as compared to group with IPI ≤24 months in terms of perinatal mortality, preterm births, low birth weight and admission to neonatal unit / neonatal ICU.Conclusion: Our study concludes that there is a significant impact of interpregnancy interval on maternal and perinatal outcome which also signifies the importance of spacing and contraception.However this study being a small pilot study, further larger studies are required on this topic in future to consolidate the results.
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