Dylan Griffith

University Teaching Hospital

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Paul Owen

AstraZeneca (United Kingdom)

Andrew Slaney

University of Hertfordshire

Graham Tytherleigh-Strong

Addenbrooke's Hospital

Henrike Andresen

Hochschule Bremerhaven

Colin Bath

AstraZeneca (United Kingdom)

Ellen Simkiss

AstraZeneca (United Kingdom)

Kevin P. Cross

Institute for Behavioral Medicine

Roger Northwood

AstraZeneca (United Kingdom)

Benjamin Dwyer

Massachusetts Institute of Technology

Andrew S. Brierley

University of St Andrews

Cooperative Institutions

AstraZeneca (United Kingdom)

Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung

Helmholtz Institute for Functional Marine Biodiversity

Carl von Ossietzky Universität Oldenburg

University of South Wales

University of Hertfordshire

University of Portsmouth

Addenbrooke's Hospital

Cambridge University Hospitals NHS Foundation Trust

University of Cambridge

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Implementation and Development of an Automated, Ultra-High-Capacity, Acoustic, Flexible Dispensing Platform for Assay-Ready Plate Delivery

SLAS TECHNOLOGY (2012)

Dylan Griffith Roger Northwood Paul Owen Ellen Simkiss Andrew S. Brierley

Compound management faces the daily challenge of providing high-quality samples to drug discovery. The advent of new screening technologies has seen demand for liquid samples move toward nanoliter ranges, dispensed by contactless acoustic droplet ejection. Within AstraZeneca, a totally integrated assay-ready plate production platform has been created to fully exploit the advantages of this technology. This enables compound management to efficiently deliver large throughputs demanded by high-throughput screening while maintaining regular delivery of smaller numbers of compounds in varying plate formats for cellular or biochemical concentration-response curves in support of hit and lead optimization (structure-activity relationship screening). The automation solution, CODA, has the capability to deliver compounds on demand for single- and multiple-concentration ranges, in batch sizes ranging from 1 sample to 2 million samples, integrating seamlessly into local compound and test management systems. The software handles compound orders intelligently, grouping test requests together dependent on output plate type and serial dilution ranges so that source compound vessels are shared among numerous tests, ensuring conservation of sample, reduced labware and costs, and efficiency of work cell logistics. We describe the development of CODA to address the customer demand, challenges experienced, learning made, and subsequent enhancements.

On demand

Sample (material)

10.1177/2211068212457159

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Benthic functional diversity along small scale natural sediment gradients: do functional aspects vary synchronously with species composition?

Dylan Griffith Jennifer Dannheim Henrike Andresen

Benthic macrofauna in the North Sea is subjected to a wide variety of anthropogenic stressors, which have a significant impact on community composition. In order to understand how these communities react to anthropogenic influences, the effect of natural environmental variation, such as temperature, salinity, or sediment characteristics, must first be understood. It is generally known that natural variation causes differences in the classical biological measures, such as the species diversity of benthic communities, however there is a paucity of studies regarding the response of functional diversity. Due to the tight linkage of functional diversity to ecosystem processes, it is important to understand these functional aspects of community diversity for understanding changes in ecological processes as a whole, and ultimately the effects on vital ecosystem services and goods. This study determined changes in functional diversity of benthic macrofaunal communities along natural sediment gradients on small spatial scales (i.e. ~5 km). Soft-bottom assemblages including infauna and epifauna in the Sylt outer reef area of the North Sea were examined, with functional diversity being based on functional traits. Changes in functional diversity are compared to species diversity and relationships present are discussed. For the first time, this study examines if there are functional changes along sediment gradients on such a small scale. The results thus deliver valuable insight on the potential effects of community changes on ecosystem functioning and process-driven changes in assemblages. Further, the outcomes provide an important framework for ecological monitoring and impact assessments for future North Sea projects.

Functional Diversity

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Arthroscopic Excision of the Sternoclavicular Joint for the Treatment of Sternoclavicular Osteoarthritis

Arthroscopy The Journal of Arthroscopic and Related Surgery (2013)

Graham Tytherleigh-Strong Dylan Griffith

Sternoclavicular joint

Refractory (planetary science)

Conservative Treatment

10.1016/j.arthro.2013.05.029

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Benthic functional diversity along small scale natural sediement gradients: do functional aspects vary synchronously with species composition?

EPIC3 (2019)

Dylan Griffith

Benthic macrofauna in the North Sea is subjected to a wide variety of anthropogenic stressors, which have a significant impact on community composition. In order to understand how these communities react to anthropogenic influences, the effect of natural environmental variation, such as temperature, salinity, or sediment characteristics, must first be understood to disentangle these from potential human pressures. This study determined changes in species and functional diversity of benthic macrofaunal communities along natural sediment gradients on small spatial scales (i.e. ~5 km). Soft-bottom assemblages including infauna and epifauna in the Sylt outer reef area of the North Sea were examined, with functional diversity being based on functional traits. Significant differences in infaunal species and functional composition were observed. Traits changing most significantly from coarse to fine sediment include longevity, age at maturity, movement type, length, and feeding mode. Significant increases in species and functional diversity were found (Simpson increasing from 0.40 to 0.83, Rao increasing from 0.10 to 0.20 from coarse to fine sand. Changes in community metrics were linked most strongly to the median grain size (MDGS) and organic content of sediments. No significant changes were found in species nor functional composition and diversity for epifaunal communities. Positive linear relationships were revealed between species and functional diversity in both infaunal (R2 = 0.95) and epifaunal (R2 = 0.99) communities. The results deliver valuable insight on the potential effects of community changes on ecosystem functioning and process-driven changes in assemblages. Further, the outcomes provide an important framework for ecological monitoring and impact assessments for future North Sea projects.

Functional Diversity

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Premiere of SacrumProfanum at the Belfast Book Festival

Kimberly Campanello Benjamin Dwyer Dylan Griffith

The Belfast Book Festival and the Crescent Arts Centre presented the world premiere of SacrumProfanum. SacrumProfanum combines contemporary music, poetry, video installation and visual art, fieldwork reportage and innovative publication design in a large-scale multimedia performance and exhibition responding to the enigmatic sheela-na-gig stone carvings. Creative Directors Kimberly Campanello (poet) and Benjamin Dwyer (composer/guitarist) approach the sheela-na-gigs through an aesthetics of damage, excavation and assemblage, drawing upon ‘found’ text, visuals and music to evoke the carvings’ potential meanings. They have brought together an innovative and dynamic team of some of the finest musicians and artists working today in order to profoundly engage with themes of identity, politics, (post)colonialism, feminism and ritual. SacrumProfanum (mixed ensemble and installation) Creative Director, Composer, Guitar: Benjamin Dwyer Creative Director, Poet, Viola: Kimberly Campanello Video Artist: Dylan Griffith Viola: Garth Knox Soprano: Sylvia O’Brien Percussion: Alex Petcu Sean-nos singer: Aine Ni Dhroighneain Uilleann pipes: Donnacha Dwyer Translator: Aifric Mac Aodha Exhibition The SacrumProfanum exhibition ran at the Crescent Arts Centre Gallery from June 9-23 and includes video and photographic installations, original manuscript scores, imagines (the complete set of limited edition lithograph books of Benjamin Dwyer’s scores for solo viola and four of Kimberly Campanello’s poems published by New Dublin Press) and fieldwork photographs and sketches of the sheela-na-gigs.

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