Amparo Galán Ortega

Sociedad Española de Medicina Interna

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Luis García de Guadiana‐Romualdo

Santa Lucía University General Hospital

Alicia Ruiz Ripa

Hospital de Mataró

Laura Altimira Queral

Parc Sanitari Sant Joan de Déu

L. Frías

Hospital Can Misses

Cristian Morales‐Indiano

Hospital Universitari Germans Trias i Pujol

MÁ

María Ángeles Juncos Tobarra

Complejo Hospitalario Universitario de Albacete

ÁL

Álex Larruzea

Institut de Seguretat Pública de Catalunya

María Arnaldos Carrillo

Hospital Universitario Virgen de la Arrixaca

Elisa Nuez‐Zaragoza

Corporació Sanitària Parc Taulí

María C. Zamorano Andrés

Hospital de Hellín

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Universitat Autònoma de Barcelona

Sociedad Española de Medicina Interna

Santa Lucía University General Hospital

Institut de Microelectrònica de Barcelona

Spanish Society of Family and Community Medicine

Hospital Universitario La Paz

Hospital Universitario Virgen de la Arrixaca

Universitat de València

Centro Nacional de Microelectrónica

Complejo Hospitalario Universitario de Toledo

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Characteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: the impact of adjusted laboratory tests in multicenter studies. A multicenter study in Spain (BIOCOVID-Spain study)

Scandinavian Journal of Clinical and Laboratory Investigation (2021)

Luis García de Guadiana‐Romualdo Daniel Morell‐García Cristian Morales‐Indiano Josep Miquel Bauçà Maria José Alcaide Martín

Identification of predictors for severe disease progression is key for risk stratification in COVID-19 patients. We aimed to describe the main characteristics and identify the early predictors for severe outcomes among hospitalized patients with COVID-19 in Spain. This was an observational, retrospective cohort study (BIOCOVID-Spain study) including COVID-19 patients admitted to 32 Spanish hospitals. Demographics, comorbidities and laboratory tests were collected. Outcome was in-hospital mortality. For analysis, laboratory tests values were previously adjusted to assure the comparability of results among participants. Cox regression was performed to identify predictors. Study population included 2873 hospitalized COVID-19 patients. Nine variables were independent predictors for in-hospital mortality, including creatinine (Hazard ratio [HR]:1.327; 95% Confidence Interval [CI]: 1.040-1.695, p = .023), troponin (HR: 2.150; 95% CI: 1.155-4.001; p = .016), platelet count (HR: 0.994; 95% CI: 0.989-0.998; p = .004) and C-reactive protein (HR: 1.037; 95% CI: 1.006-1.068; p = .019). This is the first multicenter study in which an effort was carried out to adjust the results of laboratory tests measured with different methodologies to guarantee their comparability. We reported a comprehensive information about characteristics in a large cohort of hospitalized COVID-19 patients, focusing on the analytical features. Our findings may help to identify patients early at a higher risk for an adverse outcome.

10.1080/00365513.2021.1881997

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Cardiac troponin and COVID‐19 severity: Results from BIOCOVID study

European Journal of Clinical Investigation (2021)

Luis García de Guadiana‐Romualdo Daniel Morell‐García Olaia Rodríguez‐Fraga Cristian Morales‐Indiano Ana María Lourdes Padilla Jiménez

Abstract Background Myocardial injury is a common finding in COVID‐19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, in a large population of COVID‐19 patients, and further evaluated separately the role of troponin T and I. Methods This is a multicentre, retrospective observational study enrolling patients with laboratory‐confirmed COVID‐19 who were hospitalized in 32 Spanish hospitals. Elevated troponin levels were defined as values above the sex‐specific 99th percentile upper reference limit, as recommended by international guidelines. Thirty‐day mortality was defined as endpoint. Results A total of 1280 COVID‐19 patients were included in this study, of whom 187 (14.6%) died during the hospitalization. Using a nonspecific sex cut‐off, elevated troponin levels were found in 344 patients (26.9%), increasing to 384 (30.0%) when a sex‐specific cut‐off was used. This prevalence was significantly higher (42.9% vs 21.9%; P < .001) in patients in whom troponin T was measured in comparison with troponin I. Sex‐specific elevated troponin levels were significantly associated with 30‐day mortality, with adjusted odds ratios (ORs) of 3.00 for total population, 3.20 for cardiac troponin T and 3.69 for cardiac troponin I. Conclusion In this multicentre study, myocardial injury was a common finding in COVID‐19 patients. Its prevalence increased when a sex‐specific cut‐off and cardiac troponin T were used. Elevated troponin was an independent predictor of 30‐day mortality, irrespective of cardiac troponin assay and cut‐offs to detect myocardial injury. Hence, the early measurement of cardiac troponin may be useful for risk stratification in COVID‐19.

Troponin T

10.1111/eci.13532

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Identificación de líquidos biológicos de origen desconocido

Revista del Laboratorio Clínico (2017)

Gracia Valcárcel Piedra Eva Guillén Campuzano Laura Altimira Queral Amparo Galán Ortega Ana Hernando Holgado

10.1016/j.labcli.2017.11.008

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Recomendaciones preanalíticas para la medición del equilibrio ácido-base y los gases en sangre. Recomendación (2018)

Revista del Laboratorio Clínico (2019)

Olaia Rodríguez Fraga Xavier Navarro Segarra Amparo Galán Ortega Fernando Rodríguez Cantalejo Rubén Gómez Rioja

10.1016/j.labcli.2018.12.001

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Magnitudes biológicas que tiene interés medir de modo urgente

Revista del Laboratorio Clínico (2017)

Luis García de Guadiana‐Romualdo Paloma Oliver Anna Merino González Gracia Valcárcel Piedra Eva Guillén Campuzano

10.1016/j.labcli.2016.12.001

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Perfil enzimático del infarto agudo de miocardio: propuesta diagnóstica

Amparo Galán Ortega

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Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study)

Journal of Thrombosis and Thrombolysis (2021)

Luis García de Guadiana‐Romualdo Daniel Morell‐García Emmanuel J. Favaloro Juan A. Vílchez Josep Miquel Bauçà

D-dimer

Clinical endpoint

10.1007/s11239-021-02527-y

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Abstracts of Papers Presented at the 2021 Virtual Annual Meeting of the Society for Technology in Anesthesia (STA) January 15, 2021.

Anesthesia & Analgesia (2021)

Rachel L. Watkins Jeffrey P. Phelan Gill Clayton Amparo Galán Ortega C. Nataraj

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Chronoamperometric Magneto Immunosensor for Myeloperoxidase Detection in Human Plasma Based on a Magnetic Switch Produced by 3D Laser Sintering

Analytical Chemistry (2013)

Jaume Barallat Rosa Olivé‐Monllau Javier Gonzalo‐Ruiz Raúl Ramírez-Satorras Francesc Xavier Muñoz

In this work, an amperometric immunosensor for detection of myeloperoxidase (MPO) in human plasma is reported. Detection is based on the immobilization of anti-MPO antibodies onto magnetic beads (MBs). Following MPO immunocapture and washing steps, MBs are transferred to a customized modular detector device produced by 3D laser sintering. This tool integrates electrodes, electrical connectors, and a novel magnetic switch, whose functioning is founded on the vertical displacement of a permanent magnet. In this way, magnetic switching makes possible the confinement of MBs over the working electrode for electrochemical detection, followed by the release of MBs for electrode washing and reutilization. Notably, electrochemical detection is based on the endogenous MPO activity, which reduces reagent consumption and assay time compared to sandwich assays using enzyme-labeled antibodies. After optimization, the assay could be completed in 45 min and displayed a linear response between 0.9 and 60 ng mL(-1) for MPO and a limit of detection of 0.4 ng mL(-1). The real applicability of this approach is demonstrated by the ability to carry out the successful analysis of MPO in human plasma samples. Furthermore, the results allowed the classification of patients into three groups at risk of suffering cardiac events (i.e., low, medium, or high) and correlated well with data provided by a commercially available standardized method.

Amperometry

10.1021/ac401549d

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Dual chronoamperometric detection of enzymatic biomarkers using magnetic beads and a low-cost flow cell

Biosensors and Bioelectronics (2015)

Javier Moral‐Vico Jaume Barallat Llibertat Abad Rosa Olivé‐Monllau Francesc Xavier Muñoz

10.1016/j.bios.2015.02.042

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Citations (29)