Ioanna Koniari

General University Hospital of Patras

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Nicholas G. Kounis

University of Patras

144

George Hahalis

University of Patras

Grigorios Tsigkas

General University Hospital of Patras

George D. Soufras

General University Hospital of Patras

Virginia Mplani

University of Patras

Periklis Davlouros

General University Hospital of Patras

Dimitrios Velissaris

General University Hospital of Patras

Panagiotis Plotas

University of Patras

Efstratios Apostolakis

University Hospital of Ioannina

Emmanouil Chourdakis

Krankenhaus der Barmherzigen Brüder Trier

Cooperative Institutions

General University Hospital of Patras

136

University of Patras

108

National and Kapodistrian University of Athens

University of Liverpool

Rafsanjan University of Medical Sciences

Hippocration General Hospital

Liverpool Heart and Chest Hospital

Aristotle University of Thessaloniki

University of Messina

University General Hospital Attikon

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Impact of Bacterial Infections on COVID-19 Patients: Is Timing Important?

Antibiotics (2023)

Christos Michailides Themistoklis Paraskevas Iosif Karalis Ioanna Koniari Charalampos Pierrakos

Along with important factors that worsen the clinical outcome of COVID-19, it has been described that bacterial infections among patients positive for a SARS-CoV-2 infection can play a dramatic role in the disease process. Co-infections or community-acquired infections are recognized within the first 48 h after the admission of patients. Superinfections occur at least 48 h after admission and are considered to contribute to a worse prognosis. Microbiologic parameters differentiate infections that happen after the fifth day of hospitalization from those appearing earlier. Specifically, after the fifth day, the detection of resistant bacteria increases and difficult microorganisms emerge.The aim of the study was to evaluate the impact of bacterial infections in patients with COVID-19 on the length of the hospital stay and mortality.A total of 177 patients hospitalized due to COVID-19 pneumonia were consecutively sampled during the third and fourth wave of the pandemic at a University Hospital in Greece. A confirmed bacterial infection was defined as positive blood, urinary, bronchoalveolar lavage (BAL) or any other infected body fluid. Patients with confirmed infections were further divided into subgroups according to the time from admission to the positive culture result.When comparing the groups of patients, those with a confirmed infection had increased odds of death (odds ratio: 3.634; CI 95%: 1.795-7.358; p < 0.001) and a longer length of hospital stay (median 13 vs. 7 days). A late onset of infection was the most common finding in our cohort and was an independent risk factor for in-hospital death. Mortality and the length of hospital stay significantly differed between the subgroups.In this case series, microbial infections were an independent risk factor for a worse outcome among patients with COVID-19. Further, a correlation between the onset of infection and a negative outcome in terms of non-infected, community-acquired, early hospital-acquired and late hospital-acquired infections was identified. Late hospital-acquired infections increased the mortality of COVID-19 patients whilst superinfections were responsible for an extended length of hospital stay.

Bacterial pneumonia

Odds

Pandemic

10.3390/antibiotics12020379

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Citations (6)

Biomarkers in the clinical management of patients with atrial fibrillation and heart failure.

PubMed (2021)

Ioanna Koniari Eleni Artopoulou Dimitrios Velissaris Mark Ainslie Virginia Mplani

Atrial fibrillation (AF) and heart failure (HF) are two cardiovascular diseases with an increasing prevalence worldwide. These conditions share common pathophysiologiesand frequently co-exit. In fact, the occurrence of either condition can 'cause' the development of the other, creating a new patient group that demands different management strategies to that if they occur in isolation. Regardless of the temproral association of the two conditions, their presence is linked with adverse cardiovascular outcomes, increased rate of hospitalizations, and increased economic burden on healthcare systems. The use of low-cost, easily accessible and applicable biomarkers may hasten the correct diagnosis and the effective treatment of AF and HF. Both AF and HF effect multiple physiological pathways and thus a great number of biomarkers can be measured that potentially give the clinician important diagnostic and prognostic information. These will then guide patient centred therapeutic management. The current biomarkers that offer potential for guiding therapy, focus on the physiological pathways of miRNA, myocardial stretch and injury, oxidative stress, inflammation, fibrosis, coagulation and renal impairment. Each of these has different utility in current clinincal practice.

10.11909/j.issn.1671-5411.2021.11.010

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Citations (9)

Encephalitis, myocarditis, and thrombocytopenia after COVID-19 mRNA vaccination: Clinical and pathophysiological considerations

Journal of Neuroimmunology (2022)

Nicholas G. Kounis Virginia Mplani Periklis Dousdampanis Panagiotis Plotas Ioanna Koniari

Pathophysiology

2019-20 coronavirus outbreak

10.1016/j.jneuroim.2022.577988

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Citations (2)

Intimate Contact Could Be Dangerous for Your Health

Clinical Therapeutics (2019)

Nicholas G. Kounis Huali L. Ren Maria Kavalioti Ioanna Koniari Theoharis C. Theoharides

Kounis syndrome

Hypersensitivity reaction

Contact Allergy

10.1016/j.clinthera.2019.04.010

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Citations (3)

Corticosteroids for mild COVID-19 treatment: opening the floodgates of therapeutic benefits

QJM (2021)

Nicholas G. Kounis S. N. Kouni Virginia Mplani Ioanna Koniari

2019-20 coronavirus outbreak

10.1093/qjmed/hcab312

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Citations (2)

eComment: A comparison of the safety of aprotinin and tranexamic acid in cardiac surgery

Interactive Cardiovascular and Thoracic Surgery (2009)

Ioanna Koniari Efstratios Apostolakis Muduwa Martha

Aprotinin

10.1510/icvts.2008.198325a

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Serum CXCL10 and CXCL12 chemokine levels are associated with the severity of coronary artery disease and coronary artery occlusion

International Journal of Cardiology (2017)

Vahid Tavakolian Ferdousie Maryam Mohammadi Gholamhossein Hassanshahi Hossein Khorramdelazad Soudeh Khanamani Falahati‐pour

Collateral circulation

10.1016/j.ijcard.2017.02.011

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Citations (58)

Early stent thrombosis secondary to food allergic reaction: Kounis syndrome following rice pudding ingestion

World Journal of Cardiology (2017)

Georgios Tzanis Μaria Bonou Nikolaos Mikos Smaragda Biliou Ioanna Koniari

Kounis syndrome is the concurrence of coronary spasm, acute myocardial infarction or stent thrombosis, with allergic reactions in the setting of mast-cell and platelet activation. In this report Kounis syndrome manifesting as stent thrombosis with left ventricular thrombus formation was triggered by a food-induced allergic reaction. The allergic reaction to food was confirmed by oral rice pudding ingredients challenge test while skin tests were inconclusive. To our knowledge, this is first report of early stent thrombosis secondary to food allergic reaction in a 70-year-old man patient who was found to have left ventricular thrombus and undiagnosed hypertrophic cardiomyopathy.

Kounis syndrome

Allergic reaction

Hypersensitivity reaction

10.4330/wjc.v9.i3.283

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Citations (12)

Bioresorbable Scaffold Thrombosis

Journal of the American College of Cardiology (2017)

Nicholas G. Kounis Ioanna Koniari Nicholas Patsouras Nikolaos Koutsogiannis George Hahalis

Bioresorbable scaffold

Everolimus

10.1016/j.jacc.2017.05.081