Laurence Balas

Research Field

Direct phosphonylalkylidenephosphinylation of nucleophiles is achieved by one-pot mono dialkylphosphonoalkylation of dichlorophosphates or methylphosphonic dichloride followed, in situ, by nucleophilic substitution of the chlorine atom of the alkylidenediphosphorylated intermediate.

Chlorine atom

Substitution reaction

10.1055/s-1996-4283

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Citations (14)

9-PAHPA long term intake in DIO and db/db mice ameliorates insulin sensitivity but has few effects on obesity and associated metabolic disorders

The Journal of Nutritional Biochemistry (2022)

Béatrice Bonafos Antonio J. Cortés-Espinar Laurence Balas Laurence Pessemesse Karen Lambert

Steatosis

10.1016/j.jnutbio.2022.109216

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Citations (1)

Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date

Biochimie (2013)

Laurence Balas Michel Guichardant Thierry Durand Michel Lagarde

Confusion

Diastereomer

10.1016/j.biochi.2013.11.006

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Citations (62)

Conditions Influencing the Production of Antibodies Against the Alcohol Extract of Tubercle Bacilli1

American Review of Tuberculosis (2019)

L. Dienes Laurence Balas

Tubercle

Source

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Citations (0)

Synthesis of a potential photoactivatable anandamide analog

Bioorganic & Medicinal Chemistry Letters (2006)

Laurence Balas Maria Grazia Cascio Vincenzo Di Marzo Thierry Durand

Anandamide

10.1016/j.bmcl.2006.04.059

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Citations (8)

Pro‐resolving mediator protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates

British Journal of Pharmacology (2020)

Maï Nguyen-Chi Patricia Luz‐Crawford Laurence Balas Tamara Sipka Rafael Contreras‐López

Background and Purpose Specialized pro‐resolving mediators (SPMs) are a family of lipids controlling the resolution of inflammation and playing a role in many processes including organ protection and tissue repair. While SPMs are potent bioactive molecules in vivo , their role in epimorphic regeneration of organs in vertebrates has not been tested. Using the zebrafish larva as a robust regenerative vertebrate system, we studied the role of the SPM neuroprotectin/protectin D1 (PD1) during the caudal fin fold regeneration. Experimental Approach Regeneration of the fin fold was analysed when exposed to a synthetic PD1. The effect of PD1 on immune cell recruitment and activation was further investigated using live imaging combined with fluorescent reporter lines. Using genetic and pharmacological approaches, we dissected the role of neutrophils and macrophages on driving the pro‐regenerative effect of PD1. Key Results We showed that PD1 improves fin fold regeneration. Acting in a narrow time window during regeneration, PD1 accelerates the resolution of inflammation without affecting the initial kinetic of neutrophil recruitment but instead, promotes their reverse migration potential. In addition, PD1 induces macrophage polarization switch towards non‐inflammatory states in both zebrafish and mammalian system. Finally, macrophages but not neutrophils are essential for PD1‐mediated regeneration. Conclusion and Implications These results reveal the pro‐regenerative action of PD1 and its role in regulating neutrophil and macrophage response in vertebrates. These findings strongly support the development of pro‐resolving mediators as natural therapeutic candidates for degenerative disorders and the use of the zebrafish as a tool to investigate pro‐regenerative drugs.

Mediator

Macrophage polarization

10.1111/bph.15156

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Citations (17)

DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: Putative mechanisms through PPAR activation

Free Radical Biology and Medicine (2016)

Rémy Bosviel Laurie Joumard‐Cubizolles Giulia Chinetti Dominique Bayle Corinne Copin

Palmitoylethanolamide

Proinflammatory cytokine

Cyclopentenone

Mediator

10.1016/j.freeradbiomed.2016.12.018

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Citations (48)

Increase in omega-6 and decrease in omega-3 polyunsaturated fatty acid oxidation elevates the risk of exudative AMD development in adults with Chinese diet

Free Radical Biology and Medicine (2019)

Ho Hang Leung Alex LK Ng Thierry Durand Ryo Kawasaki Camille Oger

10.1016/j.freeradbiomed.2019.10.007

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Citations (22)

ChemInform Abstract: Synthesis of 5‐(Mercaptomethyl)‐3(E)‐undecene‐1,11‐dioic Acid, a Non‐Peptide Glutathione Analogue.

ChemInform (2001)

Jean‐Frédéric Duckert Laurence Balas Jean‐Claude Rossi

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.200136075

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Citations (1)

Les FAHFAs, une nouvelle classe de lipides endogènes bioactifs

Cahiers de Nutrition et de Diététique (2018)

Melha Benlebna Laurence Balas François Casas Sylvie Gaillet Charles Coudray

10.1016/j.cnd.2018.01.004

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Citations (1)