Carla Cristina Perez

Universidade Estadual de Londrina

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Luiz C. Dias

Universidade Estadual de Campinas (UNICAMP)

Marcelle de Lima Ferreira Bispo

Universidade Estadual de Londrina

Alexandre Orsato

Universidade Estadual de Londrina

Juliana Fattori

Laboratório Nacional de Ciência e Tecnologia do Bioetanol

Carlos Roque D. Correia

Hospital de Clínicas da Unicamp

Gabriel Felix da Silva Gomes

Universidade Estadual de Londrina

Camilo Henrique da Silva Lima

Universidade Federal do Rio de Janeiro

Kaio Maciel de Santiago-Silva

Universidade Estadual de Londrina

Andrea M. Aguilar

Universidade Federal de São Paulo

Priscila Goes Camargo

Universidade Estadual de Londrina

Cooperative Institutions

Universidade Estadual de Londrina

Universidade Estadual de Campinas (UNICAMP)

Universidade de São Paulo

Universidad de Valladolid

Universidade Estadual Paulista (Unesp)

Centro Universitário de Araraquara

Universidade Federal do Rio de Janeiro

Universidade Estadual do Centro-Oeste

Universidade Federal do Ceará

Centre National de la Recherche Scientifique

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ChemInform Abstract: An Efficient Procedure for the Synthesis of 2‐N‐Boc‐amino‐3,5‐diols.

ChemInform (2008)

Luiz C. Dias Juliana Fattori Carla Cristina Perez Vanda Oliveira Andrea M. Aguilar

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.200843068

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Synthesis of the C4–C17 Fragment of Saliniketals A and B

European Journal of Organic Chemistry (2013)

Luiz C. Dias Carla Cristina Perez

Abstract A highly stereoselective synthesis of the C4–C17 fragment of saliniketals A and B was completed. The key steps in this synthesis included a syn ‐aldol reaction mediated by a boron enolate and a double diastereodifferentiating aldol reaction mediated by a titanium enolate. Moreover, a substrate‐controlled Grignard reaction, an intramolecular Wacker‐type cyclization and a Seyferth–Gilbert homologation provided the C4–C17 fragment of saliniketals A and B in 16 steps and with a 7 % overall yield.

Aldol reaction

Fragment (logic)

10.1002/ejoc.201300012

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Citations (4)

Addition of chiral and achiral allyltrichlorostannanes to chiral±-alkoxy aldehydes

Journal of the Brazilian Chemical Society (2009)

Luiz C. Dias Tatiana Augusto Carla Cristina Perez Leif Steil

Aliltricloroestananas quirais e aquirais reagem com α-alcóxi aldeídos quirais para fornecer alcoóis homoalílicos com moderados a bons níveis de diastereosseletividade 1,4-syn

10.1590/s0103-50532009000400024

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Citations (6)

Reformulação da exposição do museu de minerais e rochas do instituto de química de Araraquara

Congresso de Extensão Universitária (2003)

Miguel Fernández Ruiz Camila Nogueira Machetti Carla Cristina Perez Clarice Yumi Hiramatsu Eliana Cornélio Alves

Universidade Estadual Paulista (UNESP), Instituto de Quimica (IQ), Departamento de Bioquimica e Tecnologia Quimica, Araraquara, SP

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Design of Experiments Applied to Heck-Matsuda Arylations. Optimizing the Synthesis of Resveratrol, DMU and Stilbene Derivatives

Proceedings of the 15th Brazilian Meeting on Organic Synthesis Proceedings (2013)

Carlos Roque D. Correia Carla Cristina Perez

Stilbene and its derivatives have been attracting considerable attention from the scientific community due to its multiple human health benefits, including chemoprevention and antitumor activity. In 2008 our group completed the synthesis of resveratrol 1, DMU-212 2 (figure 1) and other stilbene derivatives using as key step the Matsuda-Heck arylation. Although effective, we had to rely on benzonitrile as the ideal solvent to achieve high yields and stereoselectivity. Our main goal with this study was the preparation of these derivatives using even more practical and greener conditions.

Benzonitrile

Heck Reaction

10.5151/chempro-15bmos-bmos2013_201381915267

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Sintese de 2-amino-3, 5-diois (1-deoxi-5-hidroxi-esfingolipidios

Carla Cristina Perez

Neste trabalho descrevemos a reacao diastereosseletiva entre aldeidos quirais N-Boc-a-aminoaldeidos e uma aliltricloroestanana aquiral fornecendo 1,2-syn N-Boc-aminoalcoois em altas diastereosseletividades. A estereoquimica relativa 1,2-syn dos produtos de adicao foi determinada apos conversao dos alcoois homoalilicos nas correspondentes N-Boc-oxazolidinonas seguido pela analise das constantes de acoplamento no espectro de RMN de H. O tratamento dos alcoois homoalilicos com quantidade catalitica de OsO4 na presenca de NaIO4 forneceu as correspondentes 4-N-Boc-amino-3-hidroxicetonas. E importante ressaltar que nao havia metodologias na literatura descrevendo a obtencao de 4-N-Boc-amino-3-hidroxicetonas, sendo este um metodo eficiente para obtencao dessa classe de compostos. A reducao diastereosseletiva das 4-N-Boc-amino-3,5-hidroxicetonas forneceu os aminodiois 1,3-syn e 1,3-anti, respectivamente. A estereoquimica relativa 1,3 foi determinada apos a conversao dos aminodiois nos correspondentes isopropilideno acetais e posterior analise de RMN de C Abstract

10.47749/t/unicamp.2008.423932

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ROTATIONAL SPECTRA OF PHENYLALANINE, TIROSINE AND TRYPTOPHAN

64th International Symposium On Molecular Spectroscopy (2009)

Santiago Mata Carla Cristina Perez M. Eugenia Sanz Susana Blanco Juan C. López

Author Institution: Grupo de Espectroscop\ia Molecular (GEM), Departamento de Qu\imica F\isica y; Qu\imica Inorganica, Facultad de Ciencias, Universidad de Valladolid, E-47005 Valladolid, Spain

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Improved synthesis of bioactive stilbene derivatives applying design of experiments to the Heck–Matsuda reaction

New Journal of Chemistry (2014)

Carla Cristina Perez Jesus M. Pena Carlos Roque D. Correia

Design of experiments (DOE) was instrumental to optimize reaction conditions which allowed the efficient synthesis of key bioactive stilbenes.

Heck Reaction

10.1039/c4nj00601a

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Citations (11)

Acetoxy DMU-loaded carboxymethylchitosan nanocapsules: preparation and in vitro release evaluation followed by an analytical methodology validation

Soft Materials (2021)

Joslaine Jacumazo Carla Cristina Perez Najeh Maissar Khalil Carlos Almeida

Acetoxy DMU (Ac.DMU – 1,2,3-trimethoxy-5-(4-acetoxystyryl) benzene) is a potential new drug, compared to resveratrol, due to its improved pharmacokinetic properties. Nanoencapsulation using Ac.DMU and carboxymethylchitosan (CMCh) polymer is a promising alternative for improving the bioavailability of drugs in human bodies. Nanocapsules (NCs) based on CMCh with Ac.DMU (Ac.DMU-NCs) by emulsion solvent diffusion technique in different drug-to-polymer ratios have been prepared with encapsulation efficiency of 69.4% and 51.5% and characterized by dynamic light scattering, ζ-potential, and infrared spectroscopy techniques. In vitro release experiments of free Ac.DMU and Ac.DMU-NCs showed an improvement in the solubility of Ac.DMU by NCs, enabling a fast drug release rate. In addition, the method was validated through analyses of specificity, linearity, limit of detection and quantification, accuracy, and precision according to the standards suggested by the International Conference on Harmonization. UV–Vis spectroscopy used to quantify Ac.DMU ensured reliable results for the amount of encapsulated Ac.DMU. The results suggest a promising potential of NCs as carriers of the hydrophobic drug Ac.DMU for controlled release.

Nanocapsules

10.1080/1539445x.2021.1992426

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Amino Acids and Sugars in the Gas Phase: Microwave Data for Astrochemistry

IAUS (2011)

Santiago Mata C. Cabezas Marcelino Varela Isabel Peña Carla Cristina Perez

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Citations (1)