Songchuan Tian

Shanghai Institute of Organic Chemistry

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Weiwei Zi

Nankai University

Dawei Ma

Chinese Academy of Sciences

Xuejun Liu

Qingdao University

Lijun Guo

Northeast Petroleum University

Hao Lü

Guangxi Medical University

Xiaodong Chen

Jilin University

Faguang Mo

Cooperative Institutions

Chinese Academy of Sciences

Shanghai Institute of Organic Chemistry

Qingdao University

Affiliated Hospital of Qingdao University

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Wenzhou Medical University

Tianjin Agricultural University

Dalian University of Technology

Nanjing Tech University

The First People’s Hospital of Lianyungang

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Potentially Biomimetic Total Synthesis and Relative Stereochemical Assignment of (±)‐Gracilamine

Angewandte Chemie International Edition (2012)

Songchuan Tian Weiwei Zi Dawei Ma

Gracil(e): The total synthesis of gracilamine features a potentially biomimetic intramolecular [3+2] cycloaddition to assemble its two fused five-membered rings and a debenzylation/ring-opening reaction to obtain the aldehyde intermediate (see scheme). The success of this synthesis provides a circumstantial evidence that supports the biosynthesis pathway of gracilamine proposed previously. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Circumstantial evidence

10.1002/anie.201205711

Cite

Citations (39)

Development of Kilogram-Scale Synthesis of EGFR Inhibitor EAI045

Organic Process Research & Development (2019)

Hao Lü Lijun Guo Xiaodong Chen Faguang Mo Songchuan Tian

Herein, we report a synthetic route for an EGFR inhibitor, 2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl) acetic acid (EAI045), using a three-step approach. This short and efficient route is the first report of a scalable process for EAI045, which employs a convergent three-component coupling strategy as the key step, producing EAI045 in good yield on kilogram scale.

Kilogram

10.1021/acs.oprd.8b00276

Cite

Citations (5)

Potentially Biomimetic Total Synthesis and Relative Stereochemical Assignment of (±)-Gracilamine

Angewandte Chemie (2012)

Songchuan Tian Weiwei Zi Dawei Ma

Gra„z“il: Die Totalsynthese von Gracilamin umfasst eine intramolekulare [3+2]-Cycloaddition zum Aufbau der beiden kondensierten fünfgliedrigen Ringe und eine Debenzylierungs-/Ringöffnungs-Reaktion, die zum Aldehyd-Intermediat führt (siehe Schema). Der Erfolg der Synthese ist ein Indiz für die Richtigkeit des vorgeschlagenen Biosynthesewegs.

10.1002/ange.201205711

Cite

Citations (11)