Xiao‐Jiao Du

South China University of Technology

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Jun Wang

Northwestern Polytechnical University

Song Shen

South China University of Technology

Xianzhu Yang

South China University of Technology

Lin‐Fan Zhu

University of Science and Technology of China

Yuan-Chen Xu

University of Science and Technology of China

Cong‐Fei Xu

South China University of Technology

Li-Han Wang

Kunming University of Science and Technology

Hongjun Li

Zhejiang University

Shu-Xing Wang

University of Giessen

Ying‐Li Luo

Jiangnan University

Cooperative Institutions

University of Science and Technology of China

South China University of Technology

Chinese Academy of Sciences

Hefei National Center for Physical Sciences at Nanoscale

Hefei University

Guangzhou Medical University

Guangzhou First People's Hospital

University of Chinese Academy of Sciences

Sun Yat-sen University

Jiangsu University

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Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy

Advanced Materials (2013)

Xianzhu Yang Xiao‐Jiao Du Yang Liu Yanhua Zhu Yangzhong Liu

Rationally designed PIC nanoparticles as next-generation delivery system: we have developed a core–shell–corona PIC nanoparticle ⊕NP/[email protected] as a next-generation delivery system. ⊕NP/[email protected] exhibits prolonged circulation and enhanced drug accumulation in tumors. Subsequently, tumor pH leads to the release of ⊕NP/Pt, which facilitates cellular uptake followed by rapid intracellular cisplatin release. Using this delivery strategy cisplatin-resistant tumor growth in a murine xenograft model has been successfully suppressed. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Rational design

Cancer Therapy

Content Delivery

10.1002/adma.201303360

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Citations (137)

Two-Input Fluorescent Probe for Thiols and Hydrogen Sulfide Chemosensing and Live Cell Imaging

ACS Sensors (2016)

Chun-Guang Dai Xiu‐Ling Liu Xiao‐Jiao Du Yan Zhang Qin‐Hua Song

Development of multi-input fluorescent probes would facilitate the monitoring of multiple biomolecular events leading to a common disease pathology. Here, we reported a two-input fluorescent probe (QME-N3) based on quinoline scaffold with two distinct reactive sites, the α,β-unsaturated carbonyl at 2-site and 6-azido group, which were specific acceptors of RSH and H2S respectively. The turn-on fluorescent probe could react with the two molecules via the Michael addition at the double bond for RSH and the reduction of the azide by H2S without mutual interference, to generate the intensively fluorescent product, which could act as a two-input AND logic gate. Furthermore, QME-N3 has very low cytotoxicity and excellent stability, and the resulting sensing product has a high two-photon absorption cross section. Consequently, detection of intracellular thiols and H2S can be achieved by cell fluorescence imaging under both one- and two-photon excitations.

Quinoline

Two-photon excitation microscopy

Fluorescence-lifetime imaging microscopy

10.1021/acssensors.6b00291

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Citations (48)

Cross sections for valence-shell excitations of H2O in the 9.85–12.15-eV energy-loss range studied by high-energy inelastic electron scattering

Physical review. A/Physical review, A (2022)

Wei-Qing Xu Yi-Geng Peng J. Zhu Xiao‐Jiao Du Yuan-Chen Xu

The recent measurement of the generalized oscillator strengths (GOSs) for $\stackrel{\ifmmode \tilde{}\else \~{}\fi{}}{A}\phantom{\rule{0.28em}{0ex}}^{1}B_{1}$ and $\stackrel{\ifmmode \tilde{}\else \~{}\fi{}}{B}\phantom{\rule{0.28em}{0ex}}^{1}A_{1}$ of ${\mathrm{H}}_{2}\mathrm{O}$ exhibits the apparent deviations from the first Born approximation calculations in the large squared momentum transfer region [W. Q. Xu et al., Phys. Rev. A 103, 032808 (2021)]. Here a simplified theoretical model was proposed to calculate the GOSs of the two excitations at large momentum transfer within the second Born approximation. The accord of the experimental GOSs and the theoretical ones is improved, but the differences still exist. In addition, the GOSs and the integral cross sections for the higher excitations of ${\mathrm{H}}_{2}\mathrm{O}$ in 9.85--12.15 eV are presented, which could be used to complete the database of electron-impact excitation cross sections of ${\mathrm{H}}_{2}\mathrm{O}$ and be beneficial for modeling interaction processes between electrons and ${\mathrm{H}}_{2}\mathrm{O}$ in the earth's atmosphere, plasmas, radiation physics, biology, etc.

Momentum transfer

Valence electron

Momentum (technical analysis)

10.1103/physreva.105.032801

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Citations (2)

Genome-centric metagenomics and methanogenic pathway analysis for acclimated anaerobic digestion of chicken manure with high ammonia stressed under thermophilic condition

Environmental Research (2024)

Y. Li Dong-min Yin Xiao‐Jiao Du Hao-xuan Li X. Zhang

Extremophile

Chicken manure

Digestion

10.1016/j.envres.2024.119453

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Citations (2)

Ratiometric Two-Photon Fluorescent Probes for Mitochondrial Hydrogen Sulfide in Living Cells

The Journal of Organic Chemistry (2014)

Xiu‐Ling Liu Xiao‐Jiao Du Chun-Guang Dai Qin‐Hua Song

Hydrogen sulfide (H2S) is an important signaling molecule with diverse biological roles. Various fluorescent probes for H2S with biological application have been developed. However, two-photon ratiometric imaging of mitochondrial H2S is scarce. In this paper, we report two ratiometric two-photon probes, AcHS-1 and AcHS-2, which employ 4-amino-1,8-naphthalimide as the fluorophore and 4-azidobenzyl carbamate as the H2S response site. These probes exhibit high selectivity toward H2S over biothiols and other reactive species, low detection limits of 50-85 nM, low cytotoxicity, and high stability under physiological conditions. Furthermore, through cell imaging with one-photon and two-photon microscopy, MCF-7 cells incubated with two probes show a marked change in emission color from blue to green in response to H2S. Cell images costraining with a mitochondrial dye reveal that AcHS-2 is a mitochondria-specific two-photon probe for H2S. These results show that AcHS-2 may find useful applications in biological research such as tracking mitochondrial H2S in living biological specimens.

Two-photon excitation microscopy

10.1021/jo5014838

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Citations (110)

Cross sections for the electron-impact excitations Ã1B1 and B̃1

Physical review. A/Physical review, A (2021)

Wei-Qing Xu Zi-Ru Ma Yi-Geng Peng Xiao‐Jiao Du Yuan-Chen Xu

Understanding the role of inelastic electron scattering in water is of fundamental importance in various fields ranging from atmospheric chemistry to radiation biology. The lack of accurate excitation cross sections for water results in a large uncertainty, for example, in the track structure simulation for modeling radiation damage to DNA. The large differences of the integral cross sections (ICSs) for the optical-allowed excitations ${\stackrel{\ifmmode \tilde{}\else \~{}\fi{}}{A}}^{1}{B}_{1}$ and ${\stackrel{\ifmmode \tilde{}\else \~{}\fi{}}{B}}^{1}{A}_{1}$ of ${\mathrm{H}}_{2}\mathrm{O}$ among experiments and theories have been maintaining for decades. To resolve this issue, by combining the ab initio calculation with the electron correlation being taken into account accurately, we compare the ICSs determined by high-energy electron scattering with the existing experiments at low and intermediate energies and theories, where the present experiment eliminated the errors from the spectral deconvolution in low-energy measurements. Our work provides a recommendation for the ICSs of the two excitations from thresholds up to several keV, and suggests the existing selected ICSs for ${\mathrm{H}}_{2}\mathrm{O}$ be revised for accurate modeling radiation effects in biological matter and describing the transport properties of electrons in aqueous systems.

10.1103/physreva.103.032808

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Citations (8)

Enhanced drug delivery to hepatocellular carcinoma with a galactosylated core–shell polyphosphoester nanogel

Biomaterials Science (2013)

Juan Wu Tianmeng Sun Xianzhu Yang Jing Zhu Xiao‐Jiao Du

Effective systemic therapy is often necessary to treat hepatocellular carcinoma (HCC). We synthesized a Gal-PPE nanogel consisting of a cross-linked polyphosphate core and galactosylated poly(ethylene glycol) arms for enhanced doxorubicin delivery to diethylnitrosamine-induced HCC in rats. The Gal-PPE nanogel exhibited high affinity to HepG2 cells in vitro, mediated by the asialoglycoprotein receptor. In vivo studies revealed that the Gal-PPE nanogel was taken up more efficiently by hepatocytes, in contrast to m-PPE nanogel. Consequently, doxorubicin delivery with Gal-PPE significantly inhibited the progress of HCC, reducing neoplastic liver nodules and prolonging the survival time of HCC rats more significantly. These results demonstrate the potential of Gal-PPE as a nanocarrier for improved HCC chemotherapy.

Nanogel

Asialoglycoprotein receptor

Nanocarriers

10.1039/c3bm60099h

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Citations (14)

Electronic excitations of CH2Cl2 studied by fast electron scattering

Journal of Quantitative Spectroscopy and Radiative Transfer (2022)

Zhi-Wei Nie Shu-Xing Wang Kun Ma Li-Han Wang Yuan-Chen Xu

10.1016/j.jqsrt.2022.108227

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Citations (1)

A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery

Biomaterials Science (2015)

Rong Sun Xiao‐Jiao Du Chunyang Sun Song Shen Yang Liu

Zwitterionic polyphosphoester containing polymers are synthesized and evaluated as an alternative to poly(ethylene glycol) block copolymers for anticancer drug delivery.

Polylactic Acid

10.1039/c4bm00430b

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Citations (31)

Tumor‐Microenvironment‐Activatable Polymer Nano‐Immunomodulator for Precision Cancer Photoimmunotherapy

Advanced Materials (2021)

Jing Liu Shasha He Ying‐Li Luo Yue Zhang Xiao‐Jiao Du

Cancer nanomedicine combined with immunotherapy has become a promising strategy for treating cancer in terms of safety and potency; however, precise regulation of the activation of antitumor immunity remains challenging. Herein, a smart semiconducting polymer nano-immunomodulator (SPNI), which responds to the acidic tumor microenvironment (TME), for precision photodynamic immunotherapy of cancer, is reported. The SPNI is self-assembled by a near-infrared (NIR)-absorbing semiconducting polymer and an amphipathic polymer conjugated with a Toll-like receptor 7 (TLR7) agonist via an acid-labile linker. Upon arrival at tumor site, SPNI undergoes hydrolysis and triggers an efficient liberation of TLR7 agonist in response to the acidic TME for dendritic cell activation. Moreover, SPNI exerts photodynamic effects for direct tumor eradication and immunogenic cancer cell death under NIR photoirradiation. The synergistic action of released immunogenic factors and acidic-TME-activated TLR7 agonist can serve as an in situ generated cancer vaccine to evoke strong antitumor activities. Notably, such localized immune activation boosts systemic antitumor immune responses, resulting in enhanced cytotoxic CD8+ T infiltration to inhibit tumor growth and metastasis. Thereby, this work presents a general strategy to devise prodrug of immunotherapeutics for precise regulation of cancer immunotherapy.

Cancer Immunotherapy

Immunogenic cell death

TLR7

10.1002/adma.202106654

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Citations (120)