Yasutomo Ojima

Hiroshima City Asa Citizens Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Masazumi Okajima

Hiroshima City Asa Citizens Hospital

Masao Harano

Hiroshima City Asa Citizens Hospital

Shigehiro Shiozaki

Hiroshima City Asa Citizens Hospital

Hiroyoshi Matsukawa

Hiroshima City Asa Citizens Hospital

Motoki Ninomiya

Okinawa Prefecture

Yasuhiro Choda

Hiroshima City Asa Citizens Hospital

Hitoshi Idani

Hiroshima City Asa Citizens Hospital

Toshimasa Asahara

Hiroshima University

Takashi Kanazawa

Fukuyama City Hospital

Daisuke Satoh

Hiroshima City Asa Citizens Hospital

Cooperative Institutions

Hiroshima University

104

Okayama University

Hiroshima City Asa Citizens Hospital

Hiroshima Prefectural Hospital

City Hospital

Kyushu University

Kure Medical Center

Matsuyama Red Cross Hospital

Citizens Specialty Hospitals

Hiroshima University Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Role of nitric oxide in gastric relaxation induced by intravenous administration of lipid in conscious dogs

Gastroenterology (2000)

Hajime Haneji Masazumi Okajima M. Kikkawa Yasutomo Ojima Shintaro Nakashima

10.1016/s0016-5085(00)83659-8

Cite

Citations (0)

Heparanase expression in both normal endometrium and endometrial cancer

International Journal of Gynecological Cancer (2006)

Hasengaowa Junichi Kodama Tamon Kusumoto Narihito Seki Toshihiko Matsuo

The aim of this study was to investigate the relationship between heparanase expression and prognostic factors in endometrial cancer, as well as the relationship between heparanase expression during phases of the normal endometrial cycle. Immunohistochemical analysis of 166 endometrial cancers and 34 normal endometria in various phases of growth was performed. The heparanase expression in the late-proliferative phase of normal endometria was found to be significantly higher than in either the early-proliferative or the secretory phases (P = .012 and P = .044, respectively). Heparanase expression was also significantly higher in endometrial cancer patients with tumors of an advanced FIGO stage (P = .0003) and high FIGO grade (P = .004) and with cancers showing either deep myometrial invasion (P = .023), lymph node metastasis (P = .006), lymphvascular space involvement (P = .048), or positive peritoneal cytology (P = .010). The disease-free and overall survival rates of patients with intense heparanase expression were significantly lower than those of patients with absent or moderate heparanase expression (P = .004 and P = .002, respectively). Heparanase may participate in normal endometrial remodeling and can serve as an indicator of the aggressive potential and poor prognosis of endometrial cancers.

Heparanase

10.1136/ijgc-00009577-200605000-00069

Cite

Citations (6)

A Case of Diversion Colitis Successfully Treated with Water Soluble Dietary Fiber

Nihon Daicho Komonbyo Gakkai Zasshi (2017)

Yasutomo Ojima Masao Harano Daisuke Sumitani Masaki Kunihiro Masazumi Okajima

症例は50代男性,S状結腸膀胱ろうにて紹介,S状結腸切除+一時的回腸ストーマ造設術施行,術後3ヵ月目にストーマ閉鎖予定であったが,S状結腸吻合部狭窄を認めたため,内視鏡的拡張術を先行することとした.吻合部の狭窄に対し拡張術施行し,口側結腸を観察したところ,下行結腸は全周性に血管透見不良で,送気で容易に出血,縦方向のひび割れ所見が出現しdiversion colitis(以下DCと略す)が疑われた.DCに対し,グアーガムを含む水溶性食物繊維を回腸ストーマから肛門側に注入開始とした.投与開始2ヵ月後の内視鏡検査では,前回に比べ発赤軽減,血管透見も良好となり前回認められた炎症所見も改善,生検でもリンパ球浸潤は軽度と改善を認めた.腸管狭窄とDCは改善し術後9ヵ月目にストーマ閉鎖術を施行した.プレバイオティクスとしグアーガムを含有する水様性食物繊維の投与が有効であったDCの1例を経験したので報告する.

10.3862/jcoloproctology.70.300

Cite

Citations (1)

Duodenal Necrosis Caused by Internal Jejunal Hernia after Laparoscopic Assisted Distal Gastrectomy, Roux-en-Y Reconstruction

The Japanese Journal of Gastroenterological Surgery (2013)

Yuki Matsumi Yasuhiro Fujiwara Yasuhiro Choda Takashi Kanazawa Masao Harano

症例は74歳の男性で，2年前に他施設に於いて早期胃癌に対し腹腔鏡補助下幽門側胃切除，結腸後経路にてRoux-en-Y法再建術を施行されていた．その後非小細胞肺癌に対し当院にて化学療法を受けていた．腹痛嘔吐が出現し，その2日後に意識混濁を認めたため当院に救急搬送となった．CTにて空腸内ヘルニアに伴う絞扼性イレウスと診断し緊急手術を施行した．術中所見では前回手術に伴う癒着は軽度で，空腸が挙上空腸背側と横行結腸間膜との間隙に入り込み内ヘルニアとなり，また輸入脚側の上部空腸および十二指腸水平脚が壊死し穿孔を来していた．壊死腸管を切除し，十二指腸下行脚と空腸を吻合し手術を終了し，術後33日目に退院となった．腹腔鏡補助下手術の増加に伴い空腸内ヘルニアの増加が報告されているが，十二指腸の壊死を来した症例はまれであり文献的考察を加え報告する．

Internal hernia

Roux-en-Y anastomosis

10.5833/jjgs.2012.0143

Cite

Citations (0)

Canges of Serum Lipid Concentration and Pancreatic Enzyme Activity on the Diarrhea Calves of Japanese Black Cattle.

The Tohoku Journal Veterinary Clinics (1992)

Keiji Okada Chisato Takahashi Tatsuya Atsumi Kokoro KIKUCHI Yasutomo Ojima

出生後1日ないし14週齢の黒毛和種における下痢症子牛31頭(これらのうち白痢を呈したもの18頭、下痢10頭、出血性下痢3頭)の血清脂質および膵臓性血清酵素の病態生化学的変化について、血清トリグリセライド(TG)濃度を基にして比較検討した。TG濃度の低い白痢子牛(6頭)では、総コレステロール(TC)、遊離脂肪酸(FFA)等の脂質成分の多くと、アルブミンおよびグルコース(Glu)が低値を示し、低エネルギーで体力の消耗していることが示唆された。TG濃度の高い白痢子牛(6頭)では、対照としての健康子牛(74頭)の血液成分とほとんど差が認められず、脂質の吸収が過剰になっていることが示唆された。TGの低い下痢子牛(6頭)では、他の脂質成分も低値を示し、腸管の吸収能が低下しているものと老えられた。TGの高い下痢子牛(4頭)では、他の脂質成分が低値を、FFAおよびAmyが高値を示した。このうち、TGが著しく高かった1頭は発育不良を呈した。出血性下痢の3頭では、共通してTGが高値を示し、1頭は斃死し、他の2頭は発育不良を呈した。このうち経過を連続的に観察した発育不良の1頭でTG等の脂質成分のほかに、Amy、Lip活性値が高値を示し、急性膵炎が疑われた。以上の知見から、白痢や出血性下痢を含む子牛の下痢症では、TGおよびGlu濃度の低下とFFA濃度の上昇が認められ、エネルギーが消耗している子牛と、TG濃度が高値を示し、脂質の代謝異常が認められた子牛に分けることができた。後者にはAmyおよびLip活性値が高値を示し、急性膵炎が関与した症例が含まれ、予後の悪い傾向が認められた。

Pancreatic enzymes

10.4190/jjvc1990.15.15

Cite

Citations (1)

A Clinicopathological Study on Colorectal Cancer with Bowel Obstruction. Comparison with Resectable Annular Infiltrated Colorectal Cancer.

Nihon Daicho Komonbyo Gakkai Zasshi (1996)

Yasutomo Ojima Masazumi Okajima Toshimasa Asahara M Arita Ryohei Kobayashi

1980年から1991年の間に切除された全周性大腸癌は107例であり, このうちA群 (イレウスを伴った症例 : 16例), B群 (軽度の閉塞症状を伴った症例 : 37例), C群 (閉塞症状をまったく有しなかった症例 : 54例) に分類し, A群の臨床病理学的特徴および予後に関して他の2群と比較検討した. 年齢, 性別, 肉眼型, リンパ節転移度, 脈管侵襲および組織学的進行度では3群間に有意差は認められなかった. 腫瘍径ではA群はC群に比べ縦径は有意に短く (P<0.05), 横径も短い傾向を認めた. A群の腫瘍占拠部位は, 左側結腸に多く, 直腸に少なかった. 根治度A切除大腸癌症例, 根治度A結腸癌症例および根治度Aでかつリンパ節転移を認めない大腸癌症例の5年生存率でもA群は他の2群と有意差を認あず, イレウスの長期予後に対する影響は少ないと考えられた. イレウスをともなった大腸癌においても積極的な切除と郭清が必要と考えられた.

10.3862/jcoloproctology.49.498

Cite

Citations (0)

Heparanase expression in both normal endometrium and endometrial cancer

International Journal of Gynecological Cancer (2006)

Hasengaowa Junichi Kodama Tamon Kusumoto Narihito Seki Toshihiko Matsuo

The aim of this study was to investigate the relationship between heparanase expression and prognostic factors in endometrial cancer, as well as the relationship between heparanase expression during phases of the normal endometrial cycle. Immunohistochemical analysis of 166 endometrial cancers and 34 normal endometria in various phases of growth was performed. The heparanase expression in the late-proliferative phase of normal endometria was found to be significantly higher than in either the early-proliferative or the secretory phases (P= .012 and P= .044, respectively). Heparanase expression was also significantly higher in endometrial cancer patients with tumors of an advanced FIGO stage (P= .0003) and high FIGO grade (P= .004) and with cancers showing either deep myometrial invasion (P= .023), lymph node metastasis (P= .006), lymphvascular space involvement (P= .048), or positive peritoneal cytology (P= .010). The disease-free and overall survival rates of patients with intense heparanase expression were significantly lower than those of patients with absent or moderate heparanase expression (P= .004 and P= .002, respectively). Heparanase may participate in normal endometrial remodeling and can serve as an indicator of the aggressive potential and poor prognosis of endometrial cancers.

Heparanase

10.1111/j.1525-1438.2006.00614.x

Cite

Citations (18)

Well-differentiated endocrine cell carcinoma of ileum treated by laparoscopy-assisted surgery--a case report.

PubMed (2010)

Shinsuke Sasada Yasutomo Ojima Masahiko Nishizaki Masao Harano Hiroyoshi Matsukawa

A 72-year-old woman presented at our hospital with a 1-year history of intermittent right lower abdominal pain. Colonoscopic examination revealed a submucosal tumor with a pitted surface in the terminal ileum. Histopathological diagnosis of the carcinoid tumor was made following biopsy. Blood serotonin and urine 5-hydroxy-indoleacetic acid levels were normal, and carcinoid syndrome was not detected. Enhanced abdominal computed tomography scan and 18F-fluorodeoxyglucose positron emission tomography failed to detect multiple lesions, lymph node swelling or distant metastasis. Laparoscopy-assisted ileocecal resection with lymph node dissection was performed. The resected specimen showed a submucosal tumor with a pitted surface 11 x 11 mm in size, located at the terminal ileum. Histopathological examination revealed a well-differentiated endocrine cell carcinoma with an invasion depth to the muscularis propria. Immunohistochemical analysis showed the tumor cells to be chromogranin A and CD56-positive. The patient had no sign of recurrence for 16 months.

Chromogranin A

Carcinoid tumors

Source

Cite

Citations (0)

Long-term outcome of S-1 and cisplatin combination therapy in patients with advanced or recurrent gastric cancer

Gastric Cancer (2005)

Yoshihisa Sakaguchi Akira Kabashima K Okita Yasutomo Ojima Shinji Yamamura

Surgical oncology

Combination therapy

10.1007/s10120-004-0313-4

Cite

Citations (11)

[A 6-year survival case of locally advanced unresectable pancreatic tail cancer treated with chemo-radiation therapy].

PubMed (2010)

Hiroyoshi Matsukawa Shigehiro Shiozaki Norihisa Takakura Hideki Aoki Yasuhiro Fujiwara

We report a case of locally advanced unresectable pancreatic tail cancer patient who survived over 6 years by chemo-radiation therapy (CRT). A 61-year-old male was pointed out by CT to have pancreatic tail cancer of 5.6 cm in diameter that invaded to the stomach, left kidney and adrenal gland, nerve plexus of celiac and superior mesenteric artery, was diagnosed as locally advanced unresectable pancreatic tail cancer. CRT of gemcitabine (GEM) with RT to a primary lesion was successful. After two years and 11 months, Schnitzler's metastasis appeared and RT was effective to recover from rectal stricture. At three years and 3 months, GEM was converted to S-1. After 4 years and 5 months, paraaortic lymph node metastasis was enlarged, so chemotherapy was changed to combination of GEM + S-1. After 4 years and 10 months, upper mediastinal lymph node metastasis appeared. At 6 years and 1 month, RT to upper mediastinum for pain control was performed. Finally, 6 years and 6 months after the first diagnosis, he died of pancreatic cancer. A long-term survival of locally advanced unresectable pancreatic cancer is very rare. In the case of pancreatic cancer that CRT is effective to the remission of primary lesion, CRT is potentially useful to perform for the control of metastatic lesion or palliative therapy.

Source

Cite

Citations (1)