Hong Zhu

State Key Laboratory of Information Security

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Feng Zhang

McMaster University

Lu Fang

Second Affiliated Hospital of Nanchang University

Xiujuan Qi

Chinese Academy of Agricultural Sciences

Yadong Li

Fujian Medical University

Can Sun

Obstetrics and Gynecology Hospital of Fudan University

Chen Zhang

Sir Run Run Shaw Hospital

Lichen Yang

Chinese Center For Disease Control and Prevention

Zhimin Xin

Beijing Obstetrics and Gynecology Hospital

Shuming Zhou

Institute of High Energy Physics

Ling Sun

Xiamen University

Cooperative Institutions

Obstetrics and Gynecology Hospital of Fudan University

Zhejiang University

Chinese Academy of Sciences

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Fudan University

Singapore General Hospital

Guangzhou Medical University

Peking University

Zhengzhou University

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Basic Phenotyping of Male Fertility from 2019 to 2020 at the Human Sperm Bank of Fudan University

Phenomics (2022)

Yadong Li Can Sun Haitao Ma Hong Zhu Feng Zhang

Sperm bank

Human fertility

Male fertility

10.1007/s43657-022-00047-0

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[Study on efficiency of iron utilization in prepubertal female children].

PubMed (2014)

Yu Zhang Lichen Yang Jianhua Piao Zhenwu Huang Hong Zhu

To investigate the iron utilization of prepubertal female children.27 female children from 10 to 12 years old were selected and given 57Fe as a tracer, in conventional diet mode, the blood samples in 1 day before test, 14 days and 28 days after tracer given were taken, and were conducted into red blood cell sample. The iron content and changes of isotope abundance in samples were analyzed and combined with blood volume to get the utilization of iron in RBC.The erythrocyte incorporation rate( of dose) in 14 days and 28 days were (19.84 +/- 0.53)% and (18.75 +/- 0.40)% (P > 0.05). The erythrocyte incorporation rate( of absorption) were (93.49 +/- 2.27)% and (88.73 +/- 0.43)% respectively, and there was a significantly difference (P < 0.05).It is feasible and accurate to evaluate the iron utilization using erythrocyte incorporation rate, which is tested by single stable isotopes tracer technique. Prepubertal female children has a higher utilization of iron, and the 14 days after tracer given is a effective entry point in erythrocyte incorporation study.

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Clomiphene Citrate or Medroxyprogesterone Acetate with Human Menopausal Gonadotropin in Poor Responders during In vitro Fertilization/Intracytoplasmic Sperm Injection Treatments Combined with Embryo Cryopreservation?

Reproductive and Developmental Medicine (2019)

Lu Fang Xiujuan Qi Hong Zhu

Objective: This study aimed to compare the efficacy of clomiphene citrate (CC) with human menopausal gonadotropin (hMG) and that of medroxyprogesterone acetate (MPA) with hMG in poor responders defined according to the Bologna criteria. Methods: The data of patients with poor ovarian response (POR) according to the Bologna criteria from September 2016 to November 2017 were retrospectively reviewed. All participants received either CC + hMG or the progesterone-primed ovarian stimulation protocol (PPOS) protocol. Results: A total of 340 patients and 563 in vitro fertilization cycles were analyzed in this study. The incidence of spontaneous luteinizing hormone (LH) surge and the mean LH level on trigger day were significantly lower in the PPOS group than in the CC + HMG group (0.04% vs. 3.49% and 4.26 ± 3.59 vs. 9.38 ± 6.92 mIU/mL, respectively, P < 0.05); however, the incidence of premature ovulation was similar between the two groups. The number of viable embryos harvested was not statistically different between the two groups (1.7 ± 1.1 vs. 1.5 ± 0.8, P = 0.06). The mean dose and duration of hMG were significantly higher in the PPOS group than in the CC + hMG group (908.7 ± 556.6 vs. 177.9 ± 214.5 IU and 6.0 ± 3.4 vs. 1.2 ± 1.5 days, respectively, P < 0.05). However, the number of oocytes retrieved, number of metaphase II oocytes, and fertilization rate were comparable between the two groups. Conclusions: The CC with low-dose gonadotropin strategy was superior to the MPA with hMG protocol for POR.

Gonadotropin

Menotropins

Human chorionic gonadotropin

10.4103/2096-2924.268162

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Effects of human chorionic gonadotropin, estradiol, and progesterone on interleukin-18 expression in human decidual tissues

Gynecological Endocrinology (2017)

Fang Wang Hong Zhu Bing Li Mingxing Liu Dan Liu

Interleukin (IL)-18 is a proinflammatory cytokine which mediates a myriad of inflammatory responses during pregnancy. Changes in IL-18 levels have been linked to complications during pregnancy. This study was designed to assess the effects of estradiol, human chorionic gonadotropin (hCG), and progesterone on IL-18 expression in human decidual tissues. Uterine deciduas from women with normal pregnancy, spontaneous abortion, and progesterone treated spontaneous abortion were collected, and the effects of hormones on the viability of decidual cells and IL-18 secretion were detected by MTT and ELISA assays. We found that Estradiol, hCG, and progesterone inhibited decidual cell growth independent of dosage and time.IL-18 secretion in the spontaneous abortion group was increased in the decidual cells over time, but all hormones significantly reduced its secretion (p < 0.05). Our results indicate that estradiol, hCG, and progesterone can reduce IL-18 secretion in the cultured endometrial stromal cells from patients who experienced spontaneous abortion to the levels observed following normal pregnancy. Progesterone can significantly reduce IL-18 expression and increase growth of CD56+ CD16- uNK cells, suggesting that these activities may underlie the mechanism by which progesterone improves pregnancy outcomes.

Decidua

Human chorionic gonadotropin

Decidual cells

Decidualization

10.1080/09513590.2016.1212829

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An algorithm of pornographic image detection

Hong Zhu Shuming Zhou Jianying Wang Yin Zhong-ke

Real-time detection of pornographic images can effectively prevent pornographic images from spreading on the Internet. The methods of detection mainly focus on the identification of skin region. To overcome the disadvantages of traditional algorithms, in this paper, we propose a skin model based on the combination of YIQ, YUV, and HSV. In the step of the pre-dealing, we use white balance algorithm to achieve better skin area. Then, texture model based on Gray Level Co-Matrix (GLCM) and geometric structure of human beings are used to decrease the disruptions of the background region similar with the skin area. The features which extracted from the last images dealt by color and texture model are input into Support Vector Machines (SVM), through which the pornographic images and assorted control images are classified successfully. An experiment using 400 pornographic images and 400 assorted control images is carried out. Experimental results show that the algorithm of skin texture- based and feather-based detection has perfect performances, and the detection rate can reach 88.89%.

HSL and HSV

Gray level

10.1109/icig.2007.29

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Effect of Progestin-Primed Ovarian Stimulation Protocol in Infertile Women with Basal Follicle-Stimulating Hormone Levels ≥15 IU/L: A Retrospective Analysis

Reproductive and Developmental Medicine (2020)

Lu Fang Xiujuan Qi Hong Zhu

Objective: To evaluate the efficacy of progestin-primed ovarian stimulation (PPOS) protocol in infertile women with high basal follicle-stimulating hormone (FSH) levels ≥15 IU/L. Methods: Patients with high basal FSH levels ≥15 IU/L with autologous oocytes from September 2016 to March 2019 were reviewed. Either medroxyprogesterone acetate 4 mg/d or clomiphene citrate (CC) 50 mg/d was administered daily from day 3 to the trigger day. When serum FSH levels decreased to ≤15.0 IU/L, a low dose of human menopausal gonadotropin (hMG) 75/150 IU/d was administered to promote late follicular development. Results: Two hundred and twenty women were retrospectively analyzed in this study. Among them, 139 patients were administered with PPOS protocol as the study group, and 81 patients were administered with CC protocol as the control group. The numbers of received oocytes and viable embryos were higher in the study group than those in the control group (1.5 ± 1.2 vs. 1.2 ± 0.8 and 0.8 ± 0.8 vs. 0.5 ± 0.6, respectively, P < 0.05). However, hMG duration and dosage were significantly higher in the study group than those in the control group (4.2 ± 2.7 d vs. 1.1 ± 2.3 d and 609.1 ± 424.5 IU vs. 140.7 ± 231.3 IU, respectively, P < 0.01). Incidence of luteinizing hormone surge and cycle cancellation rate were lower in the study group than those in the control group with statistical difference (2.88% vs. 16.05% and 36.50% vs. 50.63%, respectively, P < 0.05). Conclusions: PPOS protocol can effectively downregulate the endogenous FSH levels. Compared with CC protocol, treatment with PPOS protocol in patients with high basal FSH levels ≥15 IU/L could receive more oocytes and more viable embryos.

Progestin

Gonadotropin

Basal (medicine)

10.4103/2096-2924.285780

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Effects of high progesterone on outcomes ofin vitrofertilization-embryo transfer in patients with different ovarian responses

Systems Biology in Reproductive Medicine (2015)

Pengfen Li Hong Zhu Li Tan Dongmei Zhao Liying Ma

The data of 3,841 cycles undergoing in vitro fertilization-embryo transfer (IVF-ET) in our reproductive Center between January 2003 and December 2013 were retrospectively analyzed. According to the number of oocytes retrieved, this study was divided into the high ovarian response group (oocyte retrieval≥20, 842 cycles), the moderate ovarian response group (50.05). The increased level of P on the day of hCG may affect the treatment outcomes of IVF-ET. The cut-off values of serum P seem to be associated with ovarian response. Increased ovarian response causes the cut-off values of serum P to rise.

10.3109/19396368.2015.1033779

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Citations (9)

Systematic Review and Meta-Analysis of Prophylactic Transarterial Embolization for High-Risk Bleeding Peptic Ulcer Disease

Journal of Vascular and Interventional Radiology (2021)

Jasmine Chang Tiffany Jian Ying Lye Hong Zhu Nicholas Syn Sarah Si Lin Tang

Peptic

Endoscopic treatment

10.1016/j.jvir.2020.12.005

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Pregnancy outcomes of day 5 embryo transfer in patients at high risk of developing ovarian hyperstimulation syndrome and analysis of factors affecting blastocyst formation

Journal of International Medical Research (2013)

Zhimin Xin Hong Zhu Haixia Jin Wenyan Song Yingpu Sun

Objectives To investigate the effects of day 5 embryo transfer (D5ET) compared with day 3 embryo transfer (D3ET) in patients at high risk of developing ovarian hyperstimulation syndrome (OHSS); to analyse factors affecting blastocyst formation. Methods Patients at high risk of developing OHSS underwent either D3ET or D5ET. Results A total of 253 patients received D3ET; 263 received D5ET. The number of embryos transferred was lower in the D5ET group than in the D3ET group. There were no between-group differences in pregnancy or live birth rates. Implantation rate was higher, and multifetation rate lower, in the D5ET group compared with the D3ET group. In addition, the incidence of moderate or severe OHSS was lower in the D5ET group than in the D3ET group. The woman’s age, gonadotrophin dosage and insemination method were associated with the quality of blastocyst formation. Conclusions In patients with a high risk of developing OHSS, compared with D3ET, D5ET decreased the multifetation rate and the incidence of moderate or severe OHSS, but did not affect the pregnancy or live birth rate. Women of a younger age, who have had an appropriate gonadotrophin dose and insemination by in vitro fertilization, are suitable candidates for blastocyst transfer.

Ovarian hyperstimulation syndrome

Blastocyst Transfer

Live birth

Controlled ovarian hyperstimulation

10.1177/0300060513485910

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Evaluation of inactivated COVID-19 vaccine on semen parameters in reproductive-age males: a retrospective cohort study

Asian Journal of Andrology (2022)

Hong Zhu Xiao Wang Feng Zhang Yong Zhu Mei‐rong Du

During the coronavirus disease (COVID-19) epidemic, there have been concerns about the impact of vaccines on people's fertility, including the fertility of those who are currently preparing for pregnancy and those who might become pregnant in future. However, there is still a lack of research on the effect of the COVID-19 vaccine on male fertility, and it is not surprising that couples and donors have concerns regarding vaccination. In this study, a retrospective cohort study was conducted to examine semen quality before and after receipt of the inactivated COVID-19 vaccine. There were no statistically significant changes in semen parameters (volume, sperm concentration, progressive motility, and total progressive motile count) after two doses of vaccine (all P > 0.05). In summary, our study updates the most recent studies on the effects of the COVID-19 vaccine on male fertility, and the information from this study could be used to guide fertility recommendations for assisted reproductive technology (ART) patients and donors.

Semen quality

Semen Analysis

10.4103/aja202225

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Citations (27)