Cristina Valcárcel‐Nazco

Servicio Canario de la Salud

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Lidia García‐Pérez

Health Research Institute of the Balearic Islands

Renata Linertová

Servicio Canario de la Salud

Iván Castilla‐Rodríguez

Universidad de La Laguna

Laura Vallejo‐Torres

Universidad de Las Palmas de Gran Canaria

Pedro Serrano‐Aguilar

Servicio Canario de la Salud

Lilisbeth Perestelo‐Pérez

Servicio Canario de la Salud

Javier Mar

Association of Electronic and Information Technologies

Tasmania del Pino‐Sedeño

Servicio Canario de la Salud

Pedro Serrano‐Aguilar

Fundación Canaria de Investigación Sanitaria

María M. Trujillo‐Martín

Red de Investigación en Actividades Preventivas y Promoción de la Salud

Cooperative Institutions

Servicio Canario de la Salud

Centro de Investigación Biomédica en Red

Red de Investigación en Actividades Preventivas y Promoción de la Salud

Fundación Canaria de Investigación Sanitaria

Universidad de La Laguna

Spanish Clinical Research Network

Health Research Institute of the Balearic Islands

Instituto de Salud Carlos III

Agencia de Evaluación de Tecnologías Sanitarias

Sistema Nacional de Salud

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PIH25 Cost-Effectiveness of Interventions Against Childhood Obesity

Value in Health (2011)

Juan Manuel Ramos-Goñi Cristina Valcárcel‐Nazco Iván Castilla‐Rodríguez

Present value

10.1016/j.jval.2011.08.929

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Citations (1)

Calidad de vida y salud mental en el ictus juvenil

Neurología (2023)

D. Alonso Modino L. Pérez F.M. Rosa González Ana Toledo Chávarri Cristina Valcárcel‐Nazco

El ictus provoca un importante impacto sobre la salud mental y la calidad de vida relacionada con la salud (CVRS), aspectos no suficientemente estudiados para el ictus juvenil (IJ). Evaluar la CVRS, la salud mental y la relación entre estas, y la incorporación a la actividad laboral tras un IJ. Estudio descriptivo prospectivo de pacientes con IJ entre 2016-2017. Se emplearon los cuestionarios y escalas EuroQol-5D, SF-36, NIHSS, Rankin-m, GHQ12, Hamilton Ansiedad, Hamilton Depresión y BURQOL-meter, realizados en 2 entrevistas, a los 6 y 12 meses tras el IJ. Fueron analizados 41 pacientes, con 41,8 años de media. Tras un año, la media de NIHSS fue 0,54 y el Rankin 0-2 fue 95,1%. No hubo diferencias en las escalas de calidad de vida y salud mental en el tiempo. La tasa de depresión y ansiedad al año fue de 46,3% y de 41,5% respectivamente. Los hombres y trabajadores tienen mejor CVRS. El 41,5% de los pacientes trabajaban tras un año del IJ. La calidad de vida, la salud mental y la incorporación a la vida laboral tienen relación estadísticamente significativa entre sí. El IJ altera la CVRS y los pacientes tienen alto riesgo de sufrir ansiedad y depresión, patologías infradiagnosticadas e infratratadas, las cuales condicionan la calidad de vida, así como la incorporación a la vida laboral, que se ve mermada tras el IJ. Stroke has a significant impact on mental health and health-related quality of life (HRQoL); these aspects have not been sufficiently studied in young stroke. To evaluate HRQoL, mental health, and the relationship between these variables and the incorporation of young adults into working life after stroke. We conducted a prospective descriptive study of patients with JS between 2016 and 2017, using such questionnaires and scales as EuroQol-5D, the 36-item Short Form Health Survey, National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), 12-item General Health Questionnaire, Hamilton Anxiety and Depression Rating Scales, and BURQOL-meter; tests were administered at 2 interviews, held 6 and 12 months after stroke. We analysed 41 patients, with a mean age of 41.8 years. At one year, the mean NIHSS score was 0.54 and mRS score was 0-2 in 95.1%. No differences were observed over time in quality of life or mental health scales. Prevalence rates for depression and anxiety at one year were 46.3% and 41.5%, respectively. Male sex and active employment were associated with better HRQoL. A total of 41.5% of patients were in work at one year after the stroke. Statistically significant associations were observed between quality of life, mental health, and incorporation into working life. Young stroke affects HRQoL, and patients are at high risk of anxiety and depression, underdiagnosed and undertreated disorders that affect quality of life and the return to work, which decreases after stroke in young adults.

10.1016/j.nrl.2022.11.006

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Cost-effectiveness of vaccines for the prevention of seasonal influenza in different age groups: a systematic review

PubMed (2018)

Cristina Valcárcel‐Nazco García Lorenzo B Tasmania del Pino‐Sedeño Lidia García‐Pérez Brito García N

Given the economic burden of seasonal influenza for the healthcare system, we performed a systematic review aiming to update available evidence on the cost-effectiveness of vaccination of seasonal influenza in different age groups, including children.A systematic review of the literature on economic evaluations of seasonal influenza vaccination programs in children and adults was carried out. The following databases were searched (January 2013 - April 2018): Medline and PREMEDLINE, EMBASE, EconLit and databases of the Centre for Reviews and Dissemination (DARE, HTA, NHS EED).A total of 11 economic evaluations were included. Methodological quality of included studies was acceptable. Scientific evidence shows that seasonal influenza vaccination programs in school-age children can be a cost-effective alternative from national health system perspective and can be cost-saving from societal perspective in European countries. However, available evidence does not allow us to conclude that influenza vaccination programs in healthy adults under 65 years of age were a cost-effective alternative in our context, due to the high uncertainty and the lack of studies carried out in Spanish context.Vaccination programs for the prevention of seasonal influenza in school-age children (3-16 years) can be a cost-effective strategy.Dada la carga económica que supone para el sistema sanitario la gripe estacional, se plantea esta revisión sistemática cuyo objetivo fue actualizar la evidencia disponible sobre el coste-efectividad de vacunación contra la gripe estacional en diferentes grupos de edad, incluyendo población infantil.Se llevó a cabo una revisión sistemática de la literatura de evaluaciones económicas de los programas de vacunación contra la gripe estacional en niños y adultos. Se realizaron búsquedas en las bases de datos (enero 2013 – abril 2018): Medline y PREMEDLINE, EMBASE, EconLit y en las bases de datos del Centre for Reviews and Dissemination (DARE, HTA, NHS EED).Se incluyeron 11 evaluaciones económicas. La calidad metodológica de los estudios incluidos fue buena. La evidencia científica muestra que los programas de vacunación contra la gripe estacional en niños en edad escolar pueden ser una estrategia coste-efectiva desde la perspectiva sanitaria en países europeos. La evidencia científica disponible hasta el momento no nos permite concluir que los programas de vacunación antigripal en adultos sanos de menos de 65 años de edad sean una alternativa costeefectiva en nuestro contexto, debido a la elevada incertidumbre existente y a la escasez de estudios realizados en el contexto español.Los programas de vacunación contra la gripe estacional en niños en edad escolar (3-16 años) pueden ser una estrategia coste-efectiva desde la perspectiva del SNS.

Seasonal influenza

EconLit

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Effectiveness of the T‐Control catheter: A study protocol

BJUI Compass (2023)

Yolanda Ramallo‐Fariña Ana Toledo Chávarri A. Amador Robayna Max Mòdol Vidal Cristina Valcárcel‐Nazco

Foley catheters have been subject to limited development in the last few decades. They fulfil their basic function of draining urine from the bladder but cause other associated problems. T-Control is a new silicone Foley catheter with an integrated fluid control valve whose design aims to reduce the risks associated with bladder catheterisation by a multifactorial approach. The general purpose of this study is to evaluate the effectiveness and cost-effectiveness of the T-Control catheter versus the Foley-type catheter in patients with Acute Urine Retention (AUR).

Foley catheter

Clinical endpoint

Foley

10.1002/bco2.285

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Citations (3)

CONCEPT-COSTS. Compendium of Healthcare Costs in Spain (CONCEPT-COSTS Database)

Zenodo (CERN European Organization for Nuclear Research) (2023)

Cristina Valcárcel‐Nazco Benjamin Rodriguez-Díaz Carmen Guirado-Fuentes Lidia García‐Pérez Francisco Estupiñán‐Romero

Technical notes and documentation The Compendium of Healthcare Costs in Spain (CONCEPT-COSTS Database) is a database of Spanish healthcare unit costs estimated from different national sources. Version 2.0 of the CONCEPT-COSTS Database contains costs estimates (expresed in EUR 2023) for a core set of service items commonly used in the chronic health problems evaluated in CONCEPT Project. It is a living document planned to be regularly updated and expanded in terms of the covered service over time. Aims of CONCEPT-COSTS project: CONCEPT-COSTS is part of the coordinated CONCEPT Project, which comprises four subprojects whose objective is to analyse the effectiveness and efficiency of care pathways (CP) in three chronic health problems of high prevalence and socioeconomic impact, which are diabetes mellitus type 2, breast cancer and ischemic stroke. As a common denominator, CONCEPT shares the innovative perspective of focusing its analysis on CP as a key determinant of healthcare adequacy, adherence to treatment, health outcomes and economic consequences. CONCEPT-COSTS' first objective is to complement the results produced by each CONCEPT clinical cohort, with a broad proposal of economic analyses based on real-world data (RWD), including incurred costs, avoidable costs and efficiency evaluation of identified CP. These results will be used to inform the clinical and management decisions about those CP to be promoted or avoided. As a second objective, CONCEPT-COSTS will identify the ethodological and logistical challenges faced by economic evaluations based on RWD, to develop a framework that will include recommendations for improvements related to feasibility, validity and transferability of results. Files included in this publication: CONCEPT_COSTS_Database_v2.csv CONCEPT_COSTS_Database_v2.html Readme_v2.doc What's new Added new unit costs Some sources updated

Compendium

10.5281/zenodo.10345341

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COSTE-EFECTIVIDAD DE LA VACUNACIÓN CONTRA LA GRIPE ESTACIONAL PARA DIFERENTES GRUPOS DE EDAD: UNA REVISIÓN SISTEMÁTICA

Revista Española de Salud Pública (2018)

Cristina Valcárcel‐Nazco Borja García Lorenzo Tasmania del Pino‐Sedeño Lidia García‐Pérez Noé Brito García

RESUMEN Fundamentos: Dada la carga economica que supone para el sistema sanitario la gripe estacional, se plantea esta revision sistematica cuyo objetivo fue actualizar la evidencia disponible sobre el coste-efectividad de vacunacion contra la gripe estacional en diferentes grupos de edad, incluyendo poblacion infantil. Metodos: Se llevo a cabo una revision sistematica de la literatura de evaluaciones economicas de los programas de vacunacion contra la gripe estacional en ninos y adultos. Se realizaron busquedas en las bases de datos (enero 2013 - abril 2018): Medline y PREMEDLINE, EMBASE, EconLit y en las bases de datos del Centre for Reviews and Dissemination (DARE, HTA, NHS EED). Resultados: Se incluyeron 11 evaluaciones economicas. La calidad metodologica de los estudios incluidos fue buena. La evidencia cientifica muestra que los programas de vacunacion contra la gripe estacional en ninos en edad escolar pueden ser una estrategia coste-efectiva desde la perspectiva sanitaria en paises europeos. La evidencia cientifica disponible hasta el momento no nos permite concluir que los programas de vacunacion antigripal en adultos sanos de menos de 65 anos de edad sean una alternativa coste-efectiva en nuestro contexto, debido a la elevada incertidumbre existente y a la escasez de estudios realizados en el contexto espanol. Conclusiones: Los programas de vacunacion contra la gripe estacional en ninos en edad escolar (3-16 anos) pueden ser una estrategia coste-efectiva desde la perspectiva del SNS.

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The identification of economically relevant health and social care services for mental disorders in the PECUNIA project

BMC Health Services Research (2023)

Paul Hinck Mencía R. Gutiérrez-Colosía Christine Duval Hans‐Helmut König Judit Simon

Abstract Background Health economic research is still facing significant problems regarding the standardization and international comparability of health care services. As a result, comparative effectiveness studies and cost-effectiveness analyses are often not comparable. This study is part of the PECUNIA project, which aimed to improve the comparability of economic evaluations by developing instruments for the internationally standardized measurement and valuation of health care services for mental disorders. The aim of this study was to identify internationally relevant services in the health and social care sectors relevant for health economic studies for mental disorders. Methods A systematic literature review on cost-of-illness studies and economic evaluations was conducted to identify relevant services, complemented by an additional grey literature search and a search of resource use measurement (RUM) questionnaires. A preliminary long-list of identified services was explored and reduced to a short-list by multiple consolidation rounds within the international research team and an external international expert survey in six European countries. Results After duplicate removal, the systematic search yielded 15,218 hits. From these 295 potential services could be identified. The grey literature search led to 368 and the RUM search to 36 additional potential services. The consolidation process resulted in a preliminary list of 186 health and social care services which underwent an external expert survey. A final consolidation step led to a basic list of 56 services grouped into residential care, daycare, outpatient care, information for care, accessibility to care, and self-help and voluntary care. Conclusions The initial literature searches led to an extensive number of potential service items for health and social care. Many of these items turned out to be procedures, interventions or providing professionals rather than services and were removed from further analysis. The resulting list was used as a basis for typological coding, the development of RUM questionnaires and corresponding unit costs for international mental health economic studies in the PECUNIA project.

Comparability

Health administration

Grey Literature

10.1186/s12913-023-09944-0

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Genicular artery embolization for knee osteoarthritis: a systematic review with meta-analysis and cost-analysis

Gaceta Sanitaria (2025)

Aránzazu Hernández-Yumar Yadira González‐Hernández Tasmania del Pino‐Sedeño Cristina Valcárcel‐Nazco Aythami de Armas‐Castellano

10.1016/j.gaceta.2025.102459

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Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial

Frontiers in Public Health (2024)

Tasmania del Pino‐Sedeño Himar González‐Pacheco Beatriz González de León Pedro Serrano-Pérez Francisco J. Acosta

Aim To assess the effectiveness of two interventions of knowledge transfer and behavior modification to improve medication adherence in patients with depressive disorders. Methods An open, multicenter, three-arm clinical trial with random allocation by cluster to usual care or to one of the two interventions. The intervention for psychiatrists (PsI) included an educational program based on a patient-centered care model. The intervention for patients and relatives (PtI) included a collaborative care program plus a reminder system that works using an already available medication reminder application. The primary outcome was patient adherence to antidepressant treatment assessed through the Sidorkiewicz Adherence Instrument. Secondary measures were depression severity, comorbid anxiety and health-related quality of life. Mixed regression models with repeated measures were used for data analysis. Results Ten psychiatrists and 150 patients diagnosed with depressive disorder from eight Community Mental Health Units in the Canary Islands (Spain) were included. Compared with usual care, no differences in long-term adherence were observed in either group PsI or PtI. The PsI group had significantly improved depression symptoms ( B = −0.39; 95%CI: −0.65, −0.12; p = 0.004) during the follow-up period. The PtI group presented improved depression symptoms ( B = −0.63; 95%CI: −0.96, −0.30; p < 0.001) and mental quality of life ( B = 0.08; 95%CI: 0.004, 0.15; p = 0.039) during the follow-up period. Conclusion The assessed interventions to improve adherence in patients with depressive disorder were effective for depression symptoms and mental quality of life, even over the long term. However, no effect on antidepressant adherence was observed.

Collaborative Care

Depression

10.3389/fpubh.2024.1320159

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Cost-effectiveness of pemetrexed in combination with cisplatin as first line treatment for patients with advanced non-squamous non-small-cell lung cancer in Spain.

PubMed (2017)

J González García Fernando Gutiérrez Nicolás Gloria Julia Nazco Casariego Cristina Valcárcel‐Nazco José Norberto Batista López

Pemetrexed

Carboplatin

10.7399/fh.2017.41.1.10142

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Citations (2)