Juana Benedı́

Universidad Complutense de Madrid

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Francisco J. Sánchez‐Muniz

Universidad Complutense de Madrid

Sara Bastida

Universidad Complutense de Madrid

Alba Garcimartín

Universidad Complutense de Madrid

Adrián Macho‐González

Albert Einstein College of Medicine

María José González‐Muñoz

Universidad de Alcalá

María Elvira López‐Oliva

Instituto de Investigación Sanitaria del Hospital Clínico San Carlos

Sagrario Martín‐Aragón

Universidad Complutense de Madrid

Aránzazu Bocanegra

Universidad Complutense de Madrid

Rocío Redondo‐Castillejo

Universidad Complutense de Madrid

Marı́a Isabel Sánchez-Reus

Universidad Complutense de Madrid

Cooperative Institutions

Universidad Complutense de Madrid

164

Redondo Optics (United States)

New York University Press

Cambridge University Press

Consejo Superior de Investigaciones Científicas

Instituto de Salud Carlos III

Centro de Investigación Biomédica en Red

Instituto de Investigación Sanitaria del Hospital Clínico San Carlos

Instituto de Ciencia y Tecnología de Alimentos y Nutrición

Universidad Autónoma de Madrid

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Antiinflammatory and antioxidant activity of plants used in traditional medicine in Ecuador

Journal of Ethnopharmacology (1998)

Beatriz de las Heras Karla Slowing Juana Benedı́E. Carretero T. Ortega

Tagetes

10.1016/s0378-8741(98)00029-4

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Citations (145)

Designing a late-stage type 2 diabetes mellitus model with brain insulin resistance and oxidative stress

Proceedings of 7th International Electronic Conference on Medicinal Chemistry (2021)

Rocío Redondo‐Castillejo Marina Hernández-Martín Luis Garcı́a-Garcı́a Juana Benedı́Adrián Macho‐González

The impairment in insulin-signaling pathway induces neurological damage [e.g., Alzheimer's disease (AD)]. When AD and type 2 diabetes mellitus (T2DM) coexists, it is known as type 3 diabetes mellitus (T3DM). The mitochondrial dysfunction promotes oxidative stress and plays an important role in brain insulin resistance (BIR) instauration, which finally leads to T3DM. This study aimed to reveal the suitability of a late-stage T2DM model induced by high-saturated fat and hypercholesterolemic diet (HFHCD) and streptozotocin-nicotinamide (STZ-NAD) injection as a T3DM model. We used an early-stage T2DM rat model as control group (C) induced by a high-saturated-fat diet; and a late-stage T2DM rat model (D) induced by a HFHCD and a low dose of STZ-NAD (65 and 225 mg/kg b.w) injection. Frontal cortex were dissected and proteins were extracted. The levels of antioxidant enzymes (SOD1, SOD2, CAT, GPx and GR), the insulin-signaling pathway markers (InsRβ, IRS-1, AKT and GSK3β) and GLUT3 were measured by Western Blotting. D rats showed significant lower levels of SOD1, SOD2 and GR, contributing to oxidative stress instauration. Moreover, D rats presented an altered insulin-signaling pathway respect to C counterparts as indicated by decreased InsRβ and IRS-1 levels and downstream signaling (AKT-GSK3β). Finally, GLUT3 levels increased in D rats improving insulin-independent glucose uptake. Our findings support that this late-stage T2DM model represents an appropriate experimental tool to study the progression of BIR in T3DM as well as evaluate the efficacy of potential neuroprotective drugs.

10.3390/ecmc2021-11504

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Effects of Restructured Pork Containing <b><i>Himanthalia elongata</i></b> on Adipose Tissue Lipogenic and Lipolytic Enzyme Expression of Normo- and Hypercholesterolemic Rats

Lifestyle Genomics (2012)

Laura González-Torres Itziar Churruca Adriana R. Schultz Moreira Sara Bastida Juana Benedı́

Inclusion of seaweeds in restructured pork (RP) would improve meat health properties.

Acetyl-CoA Carboxylase

10.1159/000343722

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Citations (17)

Chemical composition and hepatotoxic effect of Geranium schiedeanum in a thioacetamide-induced liver injury model

Pharmacognosy Magazine (2014)

Mirandeli Bautista Claudia Velázquez Minarda De la O‐Arciniega José A. Morales‐González Juana Benedı́

Pharmacognosy Magazine,2014,10,39s,s574-s580.DOI:10.4103/0973-1296.139788Published:August 2014Type:Original ArticleAuthors:Juan Gayosso-De-Lucio, Mirandeli Bautista, C Velazquez-González, M De la O Arciniega, JA Morales-González, and Juana Benedí Author(s) affiliations:Juan Gayosso-De-Lucio1, Mirandeli Bautista1, C Velazquez-González1, M De la O Arciniega1, JA Morales-González2, Juana Benedí3 1 University of the State of Hidalgo, N. Abasolo 600, Colonia Centro, CP 42,000 Pachuca, Hidalgo, Mexico 2 Escuela Medicine, National Polytechnic Institute, Mexico City, CP 11340, Mexico 3 University Autónoma de Madrid, School of Pharmacy, City University, Plaza Ramón y Cajal S / N, 28040 Madrid, Spain Abstract:One of the major components of some geraniums is geraniin, described by its discoverer as crystallizable tannin, well known as an excellent antioxidant, and also found in fruits such as pomegranate. Recently, natural antioxidants have attracted great attention from consumers over the world due to their lower toxicity than synthetics. But geraniin is not a stable compound, and also is difficult to obtain, that is why in the present study we obtained acetonylgeraniin from Geranium schideanum (Gs), a stable acetone condensate of geraniin. In the present study the effect of Gs acetone-water extract was studied in reference to postnecrotic liver regeneration induced by thioacetamide (TA) in rats. Two months male rats were pretreated with daily dose of Gs extract for 4 days (300 mg/kg) and the last day also were intraperitoneally injected with TA (6.6 mmol/kg). Samples of blood were obtained from rats at 0, 24, 48, 72 and 96 h following TA intoxication. The pre-treatment with the crude extract in the model of thioacetamide-induced hepatotoxicity in rats decreased and delayed liver injury by 66% at 24 h. This result suggests that Gs extract may be used as an alternative for reduction of liver damage. On the other hand, acute toxicity study revealed that the LD50 value of the Gs extract is more than the dose 5000 mg/kg in rats, according to the Lorke method. Keywords:Geraniin, Geranium schideanum, thioacetamide hepatotoxicityView:PDF (1.11 MB) Full Text

Thioacetamide

10.4103/0973-1296.139788

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Citations (11)

Antioxidant activity of Hypericum perforatum L. extract in enriched n-3 PUFA pork meat systems during chilled storage

Food Research International (2012)

Francisco J. Sánchez‐Muniz Raúl Olivero-David Mehdi Triki Lorena Salcedo-Sandoval María José González‐Muñoz

TBARS

Lipid Oxidation

10.1016/j.foodres.2012.07.002

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Citations (29)

MS417 BLOOD PRESSURE RESPONSE TO LOW-FAT AND WALNUT PASTE-ENRICHED MEAT VARIES IN VOLUNTEERS WITH PON1 55 AND 192 GENOTYPES

Atherosclerosis Supplements (2010)

Francisco J. Sánchez‐Muniz A Lopez Munguia Canales Sara Bastida Meritxell Nus J. Librelotto

10.1016/s1567-5688(10)70918-1

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In vitro modulation of GLP-1 activity by different aqueous and organic extracts of edible seaweeds.

Annals of Nutrition and Metabolism (2013)

Adriana Schultz Moreira Eamon Rafferty Brian Green Alba Garcimartín Juana Benedı́

Aqueous extract

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Stability of seized amphetamine during 32 months of storage

Forensic Science International Reports (2020)

Domiciana de la Fuente Eduardo Tejedor María Jesús Cuesta Jesús Miguel Tejedor Adriana Corrêa-Guimarães

The designated organisation to report on narcotic and psychotropic substances from illicit traffic is the Government Delegations distributed throughout the territory of Spain. Within its Health and Social Policy Area, there are specific laboratories responsible for preparing these expert reports. These reports certify both the identity and purity of the controlled substance and are crucial for judicial organisations to set penalties, which vary according to the purity of the seized material. Occasionally after the initial expert report included in the judicial instruction period, the judges require a re-analysis, and often the new results have different concentration from the first. This study aims to make predictable the impact that storage time has on the purity of the controlled substance to explain how two analysis developed on the same material at different times may not bring about the same result. Three different variables were measured: storage time, storage conditions (temperature and humidity), and the initial purity of the sample. The controlled substance chosen to carry out the study was amphetamine. Samples of seized substances with different degrees of purity were subdivided and stored under two different storage conditions: "E"- Environmental (temperature of 22,14° and humidity of 66,36 %) and "R"-Refrigerated (temperature of 4,7 °C and humidity of 28,29 %). Samples were analyzed at the 12th, 24th, and 32nd month. An ANOVA study of data found that the only variable which affected the purity of amphetamine was storage time, having set up a threshold for statistical significance in p < 0,05. Neither storage conditions nor original purity of the sample had any effect. It was observed a loss of purity during the storage time of 1,59 % at 12 months, 2,34 % at 24th months, and 6,43 % at 32 months. The percentual change found at 12 months and 24 months cannot be said to be a significant result since it is within the error rate associated, according to the Horwitz equation (2%), and the estimated error of the technique (5%).

Narcotic

Sample (material)

Retention time

10.1016/j.fsir.2020.100095

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Protective effects of proanthocyanidins at the intestinal levelagainst thermooxidative stress due to ingestion of sunflower oil used in frying

Anales de la Real Academia Nacional de Farmacia (2021)

Rocío Redondo‐Castillejo Aránzazu Bocanegra Feras Naes Alba Garcimartín Adrián Macho González

The repeated frying of food in sunflower oil produces thermo-oxidation and polymerization, potentially negative for health. The reaction of the gastrointestinal system to these compounds is unknown. Proanthocyanidins have antioxidant and lipid-lowering properties. We hypothesize that a carob-fruit extract rich in proanthocyanidins (CFE) improves the defense of the intestine against thermo-oxidative aggression. In sunflower oil, the thermo-oxidation produced by repeated frying of fish was studied while, in Wistar rats, the effect of jointly administering altered sunflower oil and CFE on: the digestion of thermo-oxidized compounds, postprandial lipaemia, proteins involved in lipid absorption, antioxidant and hemoxygenase-1 activity and expression in the small intestine. Twelve male Wistar rats, 200-250 g were cannulated for one week with the mixture of the thermo-oxidized oil-CFE or the thermo-oxidized oil. Thermo-oxidation was determined in sunflower oil and in the postprandial-fat of the gastrointestinal lumen, postprandial lipaemia, the proteins NPC1L1, ACAT-2 and MTP, and the antioxidant status in the duodenum, jejunum and ileum. High thermo-oxidation and polymerization levels were found on sunflower oil and fat in the gastrointestinal lumen. The administration of thermo-oxidized sunflower oil-CFE decreases the digestibility of the oil and the polymeric/thermo-oxidized compounds, reduces postprandial lipaemia, increases NPC1L1, ACAT-2, and MTP, and improves the intestinal antioxidant status and excretion of fecal polymers. The use of CFE reduces postprandial lipaemia and guarantees an adequate intestinal antioxidant status against thermo-oxidized lipids.

Sunflower oil

Lipid Oxidation

10.53519/analesranf.2021.87.03.01

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Algae and cardiovascular health

Elsevier eBooks (2013)

Francisco J. Sánchez‐Muniz A. Bocanegra de Juana Sara Bastida Juana Benedı́

Phytochemical

Red algae

10.1533/9780857098689.2.369

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Citations (8)