Kuo‐Long Lou

National Taiwan University

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Po‐Tsang Huang

Kaohsiung Armed Forces General Hospital

Yu‐Shuan Shiau

National Taiwan University

Horng‐Huei Liou

National Taiwan University Hospital

Tilman Schirmer

University of Basel

Yuh‐Yuan Shiau

National Taiwan University

Ming-Tao Lee

National Central University

Meng-Hsuan Hsieh

National Taiwan University

Chien‐Hsing Lee

China Medical University

Jürg P. Rosenbusch

University of Basel

Yen‐Chywan Liaw

Institute of Biological Chemistry, Academia Sinica

Cooperative Institutions

National Taiwan University

National Taiwan University Hospital

Chung Shan Medical University

National Cheng Kung University

National Yang Ming Chiao Tung University

China Medical University

University of Basel

National Tsing Hua University

Kaohsiung Medical University

Taipei Medical University

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Depressor effect on blood pressure and flow elicited by electroacupuncture in normal subjects

Autonomic Neuroscience (2003)

Chih-Feng Lin Jiuan-Miaw Liao Shih-Jei Tsai Ping-Yen Chiang Hua Ting

Arteriole

Intensity

10.1016/s1566-0702(03)00103-6

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Citations (17)

OMPF PORIN (MUTANT R132P)

Kuo‐Long Lou Tilman Schirmer

Porin

10.2210/pdb1gfo/pdb

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Citations (1)

Cloning, expression and characterization of CCL21 and CCL25 chemokines in zebrafish

Developmental & Comparative Immunology (2012)

I‐Na Lu Bor‐Luen Chiang Kuo‐Long Lou Po‐Tsang Huang Chung‐Chen Jane Yao

CCL21

CCL25

Blastoderm

10.1016/j.dci.2012.07.003

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Citations (30)

The effects of masseter muscle pain on biting performance

Journal of Oral Rehabilitation (2003)

Yu‐Shuan Shiau C. C. Peng Shao-Min Wen Li‐Deh Lin Jiaping Wang

The present study applied a standardized test food of known hardness to evaluate the biting performance of 20 female patients who had pain mainly in the masseter muscle during palpation. Another 20 women of a similar age group who were pain-free during examination served as controls. Electromyograms (EMG) of the masseter and sternocleidomastoid (SCM) muscles and the jaw position were recorded and measured when the subjects were biting through two types of test foods with known hardness (hard type, 20 kg hardness and extra-hard type, 60 kg hardness). Pressure-pain-threshold (PPT) values of both the patients and the normal subjects were obtained with an algometer. It was found that the PPT of the patients with pain was significantly lower and that the extra-hard food took more masseter muscle activity and more working side jaw movement in both the pain and the normal groups. During both hard and extra-hard food biting, a significantly longer duration of masseter muscle activity was found in pain patients while the total muscle activity was not significantly stronger. Strong correlation existed between SCM and masseter muscle activity during both hard and extra-hard food biting in the patient group, while such correlation was very weak in the normal group. In conclusion, painful masseter muscles required longer masseter and SCM muscle contraction time for breaking through a hard food of 20 kg and more, and co-activation of SCM and masseter muscles existed and was more evident when the food was harder or the pain was more severe.

Biting

Palpation

Bite force quotient

10.1046/j.1365-2842.2003.01159.x

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Citations (35)

Molecular simulation reveals structural determinants of the hanatoxin binding in Kv2.1 channels

Journal of Molecular Modeling (2002)

Yu-Shuan Shiau Tze-Bin Lin Horng-Huey Liou Po‐Tsang Huang Kuo‐Long Lou

Docking (animal)

10.1007/s00894-002-0095-8

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Citations (13)

Functional and structural characterization of PKA-mediated pHi gating of ROMK1 channels

Journal of Molecular Graphics and Modelling (2008)

Chien‐Hsing Lee Po‐Tsang Huang Kuo‐Long Lou Horng‐Huei Liou

10.1016/j.jmgm.2008.06.001

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Citations (5)

OMPF PORIN (MUTANT R42C)

Kuo‐Long Lou Tilman Schirmer

Porin

10.2210/pdb1gfp/pdb

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Citations (0)

SAXS/SANS structural analysis of human thrombomodulin domains

Acta Crystallographica Section A Foundations of Crystallography (2009)

Kuo‐Long Lou Po‐Tsang Huang Guey‐Yueh Shi H. Y. Wu

I briefly summarize the discussion in the Zeitschrift für Kristallographie on "What is a crystal?" [1].The best upto-date answer is that it is a solid whose Fourier spectrum contains a pure point part, in other words, it shows Bragg peaks.That rises the more general question about "What diffracts and how?" Hence, there is growing interest in quasiregular heterostructures [2].These are layer structures artificially fabricated according to certain algorithms, mainly substitution sequences.Some outstanding examples are Fibonacci, Thue-Morse, Rudin-Shapiro, paperfolding and period doubling chains (finite parts of sequences) [3].Their spectral properties are of great interest.

Small-angle X-ray scattering

Thrombomodulin

10.1107/s0108767309092836

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Citations (0)

Replacement of the Sole Histidinyl Residue in OmpF Porin fromE. coliby Threonine (H21T) Does Not Affect Channel Structure and Function

Biochemical and Biophysical Research Communications (1996)

Nathalie Saint Alexej Prilipov Ariane Hardmeyer Kuo‐Long Lou Tilman Schirmer

Porin

Residue (chemistry)

Site-directed mutagenesis

10.1006/bbrc.1996.0855

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Citations (26)

Voltage gating of Escherichia coli porin channels: Role of the constriction loop

Proceedings of the National Academy of Sciences (1997)

Prashant S. Phale Tilman Schirmer Alexej Prilipov Kuo‐Long Lou Ariane Hardmeyer

In the homotrimeric OmpF porin from Escherichia coli, each channel is constricted by a loop protruding into the beta-barrel of the monomer about halfway through the membrane. The water-filled channels exist in open or closed states, depending on the transmembrane potential. For the transition between these conformations, two fundamentally different mechanisms may be envisaged: a bulk movement of the constriction loop L3 or a redistribution of charges in the channel lumen. To distinguish between these hypotheses, nine mutant proteins were constructed on the basis of the high-resolution x-ray structure of the wild-type protein. Functional changes were monitored by measuring single-channel conductance and critical voltage of channel closing. Structural alterations were determined by x-ray analysis to resolutions between 3.1 and 2.1 A. Tethering the tip of L3 to the barrel wall by a disulfide bridge (E117C/A333C), mobilizing L3 by perturbing its interaction with the barrel wall (D312N, S272A, E296L), or deleting residues at the tip of the loop (Delta116-120) did not alter appreciably the sensitivity of the channels to an external potential. A physical occlusion, due to a gross movement of L3, which would cause the channels to assume a closed conformation, can therefore be excluded.

Porin

10.1073/pnas.94.13.6741

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Citations (82)