Introduction About 90% of persons who commit suicide suffer from mental illness. The risk is particularly high in depression, psychosis, agitation, severe anxiety disorder, post-traumatic stress disorder, hypochondriasis and borderline personality disorder. Method Aim of our study was to found connection between self-stigma, and level of suicidality in neurotic spectrum disorders. It is a cross-section study of inpatients with pharmacoresistant patients hospitalized at the psychotherapeutic ward of the Department of psychiatry, University hospital Olomouc, Czech Republic. Results . Data were gathered from 198 probands. Patients were diagnosed according ICD-10 research diagnostic criteria. There were used ISMI, BDI-II, objective and subjective CGI, Morin sleep scale, DES and MADRS item 10 (suicidality) for the assessment. Level of self-stigma highly significantly correlated with suicidality in patients with neurotic spectrum disorders. Conclusion More attention should be paid to issue of self-stigma throughout neurotic patients, especially those with suicidal thoughts and tendencies.
Turner syndrome is the only chromosome monosomy that is postnatally compatible with life. The reported incidence of TS is 1 in 2500 liveborn girls. The phenotype of these girls is highly variable, with cardiac abnormalities being life-threatening defects. The aim of the study was to reveal the possible influence of the parental origin of the X chromosome in these patients on a selected phenotype that is associated with Turner syndrome. Selected symptoms and parameters were: a bicuspid aortic valve, aortic coarctation, lymphoedema, pterygium colli, coeliac disease, thyroiditis, otitis media, diabetes mellitus 2, renal abnormalities, spontaneous puberty, and IVF.The X chromosome haplotype was determined for a group of 45,X patients verified by native FISH. A molecular diagnostic method based on the detection of different lengths of X chromosome-linked STR markers using the Argus X-12 QS kit was used to determine the X haplotype.Our results, analysed by Fisher's exact (factorial) test, suggest independence between the maternal/paternal origin of the inherited X chromosome and the presence of the anomalies that were studied (P=1 to P=0.34).In the group of 45,X patients, who were precisely selected by means of the native FISH method, no correlation was demonstrated with the parental origin of the X chromosome and the observed symptom.
V Ceske republice patři mezi indikace lecby růstovým hormonem u děti deficit růstoveho hormonu (zhruba od 70. let minuleho stoleti), Turnerův syndrom (od roku 1992), růstove selhani u chronicke renalni insuficience (od roku 1995), syndrom Prader-Willi (od roku 2001) a postnatalni růstove selhani navazujici na intrauterinni růstovou retardaci (od roku 2003). K 1. lednu 2006 je v Ceske republice leceno růstovým hormonem ve 13 centrech celkem 922 děti a dospivajicich. Z nich byl u 537 prokazan deficit růstoveho hormonu, u 159 divek Turnerův syndrom, 28 děti trpělo chronickou renalni insuficienci, 35 děti syndromem Prader-Willi a 163 postnatalnim růstovým selhanim navazujicim na intrauterinni růstovou retardaci.
Abstract Background: Bicuspid aortic valve (BAV) represents one of the strongest risk factors for aortic dissection in Turner syndrome (TS). An exact relation between the occurrence of BAV and a particular karyotype has not been established yet. The aim of this study was to determine the association between karyotype and prevalence of BAV. Methods: Sixty-seven TS patients aged between 6.6 and 32.5 years underwent cardiac magnetic resonance imaging (MRI) study. They were divided into four cytogenetic subgroups−45,X karyotype (n=27); 45,X/46,XX mosaicism (n=17); structural abnormalities of the X chromosome (n=10); and 45,X/structural abnormality of the X chromosome mosaicism (n=13). Prevalence of BAV and odds ratio (OR) compared with the general population in the whole study group, and statistical comparison of prevalences of BAV among the individual subgroups were determined. Results: Prevalence of BAV in the whole study group was established as 28.4% [OR 208.3 (95% CI – 103.8–418.0); p-value<0.0001]. Individuals with 45,X karyotype had the highest prevalence of BAV – 40.7%, p-value<0.0001. Presence of any 45,X cell line in karyotype significantly predisposed to BAV (p-value=0.05). Conclusions: The 45,X karyotype is associated with the highest prevalence of BAV. Also, the presence of the 45,X cell line in any mosaic karyotype increases the probability of BAV.
Třinactiletý chlapec byl přijat na dětske odděleni spadove nemocnice pro nocni epizodu zvraceni s přiměsi krve. Matka popisovala ve zvratcich zbytky stravy a krevni koagula. Při přijeti si stěžoval na motani a bolesti hlavy, jedenkrat zvracel, bez krve. Byl afebrilni, TF 85/min, s fyziologickým somatickým nalezem. Krvaceni z dutiny ustni ci nosu popiral. Ve vstupnich laboratornich vysetřenich byl Hb 107 g/l, urea 10,27 mmol/l, FW 30/50, koagulacni a biochemicke parametry i UZ břicha v normě. Třeti den hospitalizace se objevila melena. Chlapec se citil slabý, byl napadně bledý, měl tachykardii 120/min. V kontrolnim krevnim obrazu doslo k poklesu Hb na 55 g/l. Byl zajistěn infuzi krystaloidů, H2-blokatoru, transfuzi erytrocytarniho koncentratu a nasledně přeložen na JIP Dětske kliniky k dalsimu řeseni.
The present prospective, randomised, double-blinded clinical study was designed to investigate the commonly used anaesthetic combinations of dexmedetomidine-propofol-isoflurane and medetomidine-propofol-isoflurane on intraocular pressure and pupil size in dogs. Forty client-owned healthy dogs with no ocular abnormalities, average body weight of 25.7 ± 13.1 kg (mean ± SD) and aged 3.7 ± 2.7 years, were enrolled. Twenty four males and 16 females were included. Dogs were allocated randomly to receive dexmedetomidine i.v. at 0.005 mg/kg, dexmedetomidine at 0.01 mg/kg, medetomidine at 0.01 mg/kg or medetomidine at 0.02 mg/kg. Ten minutes later anaesthesia was induced in all dogs with propofol and maintained with isoflurane in oxygen-air. Intraocular pressure, pupil size, heart rate, respiratory frequency and arterial blood pressures (SAP, DAP) were measured prior to (baseline) and at 10 (before propofol), 20, 30, 40, 50 and 60 min after dexmedetomidine or medetomidine administration. Oxygen saturation of haemoglobin (SpO2) and end-tidal CO2 concentration (EtCO2) was monitored following anaesthesia induction. Data were analysed using Anderson-Darling and Bartlett's tests for data distribution and homogeneity of variance confirmation and ANOVA followed by Dunnett's tests for multiple comparisons. Changes were considered significant when P < 0.05. Following drug administration, pupil size, heart rate and respiratory frequency decreased significantly within groups, but did not differ between groups. No significant changes in intraocular pressure, SAP and DAP within and between groups, and SpO2 or EtCO2 between groups, were observed. Comparable doses of dexmedetomidine or medetomidine combined with propofol and isoflurane induced reductions in pupil size, respiratory frequency and heart rate, however, without a significant influence on intraocular pressure or arterial blood pressure.
