Pedro Miramóntes

Universidad Nacional Autónoma de México

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Co-Authors

G. Cocho

Universidad Nacional Autónoma de México

Wentian Li

Shanghai East Hospital

Ricardo Mansilla

Hospital Universitari Germans Trias i Pujol

Benjamín A. Itzá‐Ortiz

Universidad Autónoma del Estado de Hidalgo

Raúl Peralta

Universidad Autónoma del Estado de Morelos

ÓF

Óscar Fontanelli

Facultad Latinoamericana de Ciencias Sociales

Antonio Neme

Universidad Nacional Autónoma de México

Robert Cedergren

Université de Montréal

Cruz Vargas‐De‐León

Instituto Politécnico Nacional

Augusto Cabrera-Becerril

Universidad Nacional Autónoma de México

Cooperative Institutions

Universidad Nacional Autónoma de México

Universidad Autónoma del Estado de Morelos

Instituto Politécnico Nacional

Universidad Autónoma de la Ciudad de México

Instituto de Ecología

Center for Research and Advanced Studies of the National Polytechnic Institute

Universidad Autónoma del Estado de Hidalgo

Consejo Superior de Investigaciones Científicas

Université de Montréal

Centro Medico Nacional Siglo XXI

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The puzzling origin of the genetic code

Trends in Biochemical Sciences (1996)

Robert Cedergren Pedro Miramóntes

Genetic Code

Amino Acyl-tRNA Synthetases

Code (set theory)

10.1016/s0968-0004(96)80014-4

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Citations (13)

Increase of non-vaccine human papillomavirus types in a group of HPV-vaccinated Mexican women. Evidence of Pathogenic Strain Replacement

medRxiv (Cold Spring Harbor Laboratory) (2020)

Augusto Cabrera-Becerril Ramiro Alonso Cruz Vargas‐De‐León Pedro Miramóntes Pablo Romero-Morelos

Abstract High risk HPV infection is the etiological factor of Cervical Cancer (CC) and other types of cancer of epithelial origin. HPV 16 and 18 infections are associated with 70% of CC worldwide. At the present time, there is a vaccine that prevents this infections. In Mexico, the HPV vaccine was introduced in 2009. Even if the current vaccine is effective, some models indicate a possible scenario of Vaccine-induced Pathogen Strain Replacement (VPSR). In this report, we performed the molecular detection of HPV in a group of HPV-vaccinated Mexican women to explore a putative scenario of VPSR. We used biological samples from women who went for their routine Pap. The study included eighteen women older than 18 years of age and HPV-vaccinated. As the number of cases analyzed is relatively small, we supplemented the study with an agent-based direct computer simulation. The outcome of the numerical experiments and the analyzed cases complement each other and show that in three different scenarios, there is an increase in HPV cases approx 10 years after vaccination of the first cohort of women. The prevalence of non-vaccine HPV types increases when compared to prevalence of vaccine HPV types. This result could be interpreted as the phenomenon of Vaccine-induced Pathogenic Strain Replacement.

Etiology

Vaccine efficacy

Age groups

10.1101/2020.05.26.20113829

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¿Es posible caracterizar el espacio fenotípico a partir de las relaciones entre elementos de un plan corporal? Un análisis sistémico en la lagartija Uta stansburiana Is it possible to characterize the phenotypic space from the relationship among the elements of a body plan? A systemic analysis in the lizard Uta stansburiana

DOAJ (DOAJ: Directory of Open Access Journals) (2009)

Juan Á. Rivera Pedro Miramóntes Fausto Méndez Daniel Piñero

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Multiwall and bamboo-like carbon nanotubes from the Allende chondrite: A probable source of asymmetry

PLoS ONE (2019)

Hugo I. Cruz‐Rosas Francisco Riquelme Patrícia Santiago L. Rendón Thomas Buhse

This study presents multiwall and bamboo-like carbon nanotubes found in samples from the Allende carbonaceous chondrite using high-resolution transmission electron microscopy (HRTEM). A highly disordered lattice observed in this material suggests the presence of chiral domains in it. Our results also show amorphous and poorly-graphitized carbon, nanodiamonds, and onion-like fullerenes. The presence of multiwall and bamboo-like carbon nanotubes have important implications for hypotheses that explain how a probable source of asymmetry in carbonaceous chondrites might have contributed to the enantiomeric excess in soluble organics under extraterrestrial scenarios. This is the first study proving the existence of carbon nanotubes in carbonaceous chondrites.

Allende meteorite

Carbonaceous chondrite

Carbon fibers

Amorphous carbon

10.1371/journal.pone.0218750

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Citations (7)

Dynamics of High-Risk Nonvaccine Human Papillomavirus Types after Actual Vaccination Scheme

Computational and Mathematical Methods in Medicine (2014)

Raúl Peralta Cruz Vargas‐De‐León Augusto Cabrera Pedro Miramóntes

Human papillomavirus (HPV) has been identified as the main etiological factor in the developing of cervical cancer (CC). This finding has propitiated the development of vaccines that help to prevent the HPVs 16 and 18 infection. Both genotypes are associated with 70% of CC worldwide. In the present study, we aimed to determine the emergence of high-risk nonvaccine HPV after actual vaccination scheme to estimate the impact of the current HPV vaccines. A SIR-type model was used to study the HPV dynamics after vaccination. According to the results, our model indicates that the application of the vaccine reduces infection by target or vaccine genotypes as expected. However, numerical simulations of the model suggest the presence of the phenomenon called vaccine—induced pathogen strain replacement. Here, we report the following replacement mechanism: if the effectiveness of cross-protective immunity is not larger than the effectiveness of the vaccine, then the high-risk nonvaccine genotypes emerge. In this scenario, further studies of infection dispersion by HPV are necessary to ascertain the real impact of the current vaccines, primarily because of the different high-risk HPV types that are found in CC.

10.1155/2014/542923

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Citations (10)

The Self-Organized Chaos Game Representation for Genomic Signatures Analysis

Learning and Nonlinear Models (2008)

Antonio Neme Antonio Nido Víctor Mireles Pedro Miramóntes

Representation

10.21528/lnlm-vol6-no2-art2

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Citations (2)

Predecir el clima es una cosa, predecirlo correctamente es otra

Ciencias (México, D.F.) (1998)

Pedro Miramóntes

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A Neural Network May Show the Best Way to Learn How to Count for Students in Elementary Math Courses

Antonio Neme Vicente Liern Carrión Abril Muñoz Pedro Miramóntes Alejandra Cervera

Learning how to count in different bases has been seen as a trivial task in almost all introductory mathematics courses. However, the low performance shown by many students, while performing this task, is appalling. This situation has motivated serious research in this matter. In order to study a model of count learning, we analyze the performance of a multilayer perceptron that learns to count in several bases (5, 10, 13, 20, 60). We give evidence that it is not equivalent for the model to learn to count in all base as the errors are not equivalent, biased toward a low error when the task is to learn to count in base 20. When the task is to learn to count in all bases following a given sequence, the model shows non-equivalent errors for some bases. This may shed some light on education planning that can result in better introductory courses.

Base (topology)

Perceptron

Sequence (biology)

10.1109/micai.2008.47

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Análisis no lineal de la dinámica del cáncer

Inventio (2018)

Raúl Peralta Homero Garcés G. Cocho Pedro Miramóntes

El cáncer es una de las enfermedades complejas de mayor prevalencia a nivel mundial y el aumento de casos de este padecimiento se debe a una mayor exposición a los factores de riesgo relacionados en gran parte con el estilo de vida. Estos factores tienen la capacidad de interactuar con los genes moduladores del crecimiento y la diferenciación celular y producir mutaciones o alteraciones en el genoma. Tales mutaciones inducen un cambio en la dinámica de interacciones génicas en el interior de la célula y, como consecuencia, modifican la estabilidad de las redes de regulación génica característica de cada fenotipo celular. En este artículo se estudian las redes de regulación génica en la teoría matemática de la dinámica no lineal y sus propiedades, que las hacen parte esencial de la teoría de los sistemas complejos.

10.30973/inventio/2018.14.32/6

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La interdisciplina desde la teoría de los sistemas complejo

Ciencias (México, D.F.) (2009)

Pedro Miramóntes Elke Ãppen Pruebman Ricardo Mansilla

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Citations (4)